DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment how and qkia

DIOPT Version :9

Sequence 1:	NP_001262822.1	Gene:	how / 42596	FlyBaseID:	FBgn0264491	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_571299.1	Gene:	qkia / 30471	ZFINID:	ZDB-GENE-990415-230	Length:	383	Species:	Danio rerio

Alignment Length:	340	Identity:	177/340 - (52%)
Similarity:	221/340 - (65%)	Gaps:	31/340 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 DYLAQLLKDRKQLAAFPN---VFTHVERLLDEEIARVRASLF--QING-VKKEPLTLPEPEGSVV 135
            |||.|||.::|.:.:.||   :|||:||||||||.|||..::  .:|| |.|.||.||||.|.:|
Zfish    17 DYLMQLLNEKKLMTSLPNLCGIFTHLERLLDEEINRVRKDMYNDSVNGLVDKHPLELPEPVGPIV 81

  Fly   136 TMNEKVYVPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDANRGKPNWE 200
            .:.||::|||:|:||:|||||||||||:||||||.||||||||||:.||||||||:.||||||||
Zfish    82 HLQEKLFVPVKEYPDYNFVGRILGPRGLTAKQLEAETGCKIMVRGRSSMRDKKKEEQNRGKPNWE 146

  Fly   201 HLSDDLHVLITVEDTENRATVKLAQAVAEVQKLLVPQAEGEDELKKRQLMELAIINGTYRDTTAK 265
            ||::|||||||||||:.||.:|:.:||.||:|||||.|||||.|||.|||||||:|||||||..|
Zfish   147 HLNEDLHVLITVEDTQTRAEIKMRRAVEEVKKLLVPAAEGEDNLKKMQLMELAILNGTYRDTNIK 211

  Fly   266 S-VAAFSCVGSASYLYPAVCDEEWRRLVAASDSRLLTSTGLPGLAAQIRAPAAAPLGAPLILNPR 329
            : ..|||       |..|....:..||:||...::|.       .|.:|.|  .|.|.|::   .
Zfish   212 APTLAFS-------LAAAAAAAQGPRLIAAPPGQVLP-------PATLRPP--TPAGTPIM---N 257

  Fly   330 MTVPTTAASILSAQAAPTAAFDQTGHGMIF-APYDYANYAALAGNPLLTEYADHSGAI-KQQRRL 392
            :..||..|::| ....||........|:|: .||||.  .|||...||....:|||.: |:...|
Zfish   258 IIRPTQMATVL-PNGTPTLVPPTPDAGIIYTTPYDYP--YALAPTSLLEYPIEHSGVLGKRAWGL 319

  Fly   393 ATNREHPYQRATVGV 407
            .|:.....|..|.||
Zfish   320 GTSPFGVPQEGTPGV 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
how	NP_001262822.1	STAR_dimer	75..123	CDD:293152	26/51 (51%)
how	NP_001262822.1	SF1_like-KH	139..260	CDD:239088	94/120 (78%)
qkia	NP_571299.1	STAR_dimer	11..69	CDD:293152	26/51 (51%)
		SF1_like-KH	84..206	CDD:239088	94/121 (78%)
		Quaking_NLS	356..383	CDD:293159
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4590
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H128544
Inparanoid	1	1.050	300	1.000	Inparanoid score	I2664
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1565749at2759
OrthoFinder	1	1.000	-	-		FOG0001806
OrthoInspector	1	1.000	-	-		otm25871
orthoMCL	1	0.900	-	-		OOG6_104884
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3450
SonicParanoid	1	1.000	-	-		X1339
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.360