DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment how and Sf1

DIOPT Version :9

Sequence 1:	NP_001262822.1	Gene:	how / 42596	FlyBaseID:	FBgn0264491	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001104261.1	Gene:	Sf1 / 22668	MGIID:	1095403	Length:	639	Species:	Mus musculus

Alignment Length:	457	Identity:	104/457 - (22%)
Similarity:	177/457 - (38%)	Gaps:	134/457 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AQAQAQAQAQQQQQAPQVVVPMTPQHLTP---QQQQQSTQSIADYLAQL-LKD--RK----QLAA 91
            ::.:.:::..|.....:.|:|..|..:.|   ::|:::      |:.|| ::|  ||    .|..
Mouse    14 SKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERA------YIVQLQIEDLTRKLRTGDLGI 72

  Fly    92 FPN----------VFT-----------HVERLLDEEIARVRASLFQINGVKKEPLTLPEPEGSVV 135
            .||          ::.           ...:.|:||...:...:..:|...|.|.....|   ..
Mouse    73 PPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHTLITEMVALNPDFKPPADYKPP---AT 134

  Fly   136 TMNEKVYVPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDANRGKPNWE 200
            .:::||.:|..|:|:.||||.::||||.|.|.:|:|...|||:|||||:::.|.     |:.:.:
Mouse   135 RVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKV-----GRKDGQ 194

  Fly   201 HL---SDDLHVLITVEDTENRATVKLAQAVAEVQKLL---VPQAEGEDELKKRQLMELAIINGTY 259
            .|   .:.||.|:|....||     :.:||.:::.:|   :...|.:::|:|.||.|||.:|||.
Mouse   195 MLPGEDEPLHALVTANTMEN-----VKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTL 254

  Fly   260 RDTTAKSVAAFSCVGSASYLYPAVC------------------------------DEEWRRLVAA 294
            |:...:.:..:....:.|.....||                              |:|:..|:|.
Mouse   255 REDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAE 319

  Fly   295 SDSRLLTSTGLPGLAAQIRAPAAAPLGAPLILNPRMTVPTT---AASILS-AQAAPTAAFDQTGH 355
                 |....:|........||..||.:.    ||...|.:   ..|::| .|:.|.
Mouse   320 -----LGEAPVPASVGSTSGPATTPLASA----PRPAAPASNPPPPSLMSTTQSRPP-------- 367

  Fly   356 GMIFAPYDYANYAALAG--------------NPLLTEYADHSGAIKQQRRLATNREHPYQRATVG 406
            .|...|.:...|..:.|              :||.:....|.|             ||.|....|
Mouse   368 WMNSGPSENRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGG-------------HPMQHNPNG 419

  Fly   407 VP 408
            .|
Mouse   420 PP 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
how	NP_001262822.1	STAR_dimer	75..123	CDD:293152	13/75 (17%)
how	NP_001262822.1	SF1_like-KH	139..260	CDD:239088	48/126 (38%)
Sf1	NP_001104261.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		5/29 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	15..19		0/3 (0%)
		MSL5	17..257	CDD:227503	71/258 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..94		3/28 (11%)
		ZnF_C2HC	278..293	CDD:197667	2/14 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..584		25/122 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810