Protein Alignment how and Qki

DIOPT Version :10

• Sequence 1: NP_001262822.1
• Gene: how / 42596
• FlyBaseID: FBgn0264491
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_001152989.1
• Gene: Qki / 19317
• MGIID: 97837
• Length: 341
• Species: Mus musculus
• Alignment Length: 385
• Identity: 72/385 - (18%)
• Similarity: 121/385 - (31%)
• Gaps: 112/385 - (29%)

  Fly    36 IPLEVLEQENGTAPADWSASCTQ-----------RRTEDHAKIEQAVAVIKDH-LEKQAAATKPI 88
            |.::.|.|:.|.|..:.:..|.|           .|.||    |....:.:|| :....||..|.
Mouse    19 IGVQYLFQQTGQALQNMNPDCQQTAELIEDLNVDEREED----EGFCDISEDHTIVDPEAALSPS 79

  Fly    89 RDELRQFGGTL-------LPLLN-SAQVKTDAAELDELRMSVLVAAIEAGR-------------- 131
            ...||....|.       ||:.. .|.|....|:.:|....|.:...||..
Mouse    80 SSTLRSGSSTAVTSSVASLPVSTCPALVPDPPAQPEEPISPVPLEPEEATEDDDEDNDDDDDDDG 144

  Fly   132 IPEAMTQFLMLAGWNRWPQIVAQIYQNTRRDRQHIANLLEFIRIVPARDDRVAFYHELKKH---M 193
            ..|....:..:.|:                  ||:..|.|::             .||:.|   .
Mouse   145 DEETAVDYQNIPGF------------------QHVDRLAEYL-------------VELRTHKSLS 178

  Fly   194 VASKDYESYLG---AMFAADAFHVVYEA-------DG--KTPLNESDVKALYTTMLDGAGAYFQR 246
            :.:::....:|   ::...|...|||.|       .|  |||...:....:.:|.....||....
Mouse   179 LTNQEANEIIGLWQSLHDQDKKRVVYAARHQKRLLSGRFKTPKKPTHTPGVESTTRCVLGASSAP 243

  Fly   247 ALLTGANRYDLFLLDEHHPQLFDLLFDRIVNVSQANMRK----FNSWQMMGALCRVHRPM----- 302
            |......|            |.:.:|.|:..:..:..||    .:.|.::....|..|.:
Mouse   244 AQWPDCCR------------LVETIFIRLCTIHPSPKRKGKGTLSRWSLILQDYRRIRQLVLGNS 296

  Fly   303 -----SKVLLFRKTANLLLDHFKWEKENEYYAPMLAG-YFEVCLPDIRKD-PATAGLVTE 355
                 :.:.|.....|.|:..|...::.:..:.:|.| .....||:.::. |....|.||
Mouse   297 LVMGGTSMQLVEVNQNTLIQWFNNRQKKQELSVLLQGIQLPQHLPEAQEPLPVAKSLQTE 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
how	NP_001262822.1	STAR_dimer	75..122	CDD:435414	14/55 (25%)
		KH-I_HOW	132..236	CDD:411894	19/118 (16%)
Qki	NP_001152989.1	STAR_dimer	10..64	CDD:435414	11/48 (23%)
		Qua1 domain, involved in homodimerization. /evidence=ECO:0000250|UniProtKB:Q17339	11..82		16/66 (24%)
		KH-I_Hqk	81..183	CDD:411893	21/132 (16%)
		Qua2 domain, involved in RNA binding. /evidence=ECO:0000250|UniProtKB:Q96PU8	182..213		6/30 (20%)
		PHA03247	<211..314	CDD:223021	19/114 (17%)
		SH3-binding	276..279		0/2 (0%)
		Quaking_NLS	312..341	CDD:435421	5/28 (18%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:10506177, ECO:0000269|PubMed:29021242	324..330		0/5 (0%)