Protein Alignment how and sfa-1

DIOPT Version :10

• Sequence 1: NP_001262822.1
• Gene: how / 42596
• FlyBaseID: FBgn0264491
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_503033.1
• Gene: sfa-1 / 178486
• WormBaseID: WBGene00013808
• Length: 699
• Species: Caenorhabditis elegans
• Alignment Length: 511
• Identity: 126/511 - (24%)
• Similarity: 184/511 - (36%)
• Gaps: 166/511 - (32%)

  Fly     5 ESKAVVQQQLQQHLQQQAAAAVVAVAQQQQAQAQAQAQAQAQQQQQAPQVVVP----MTPQHLTP 65
            ||.||..:.:|       |.||||:         ..|:.:.:.:....:..||    :.|..||.
 Worm   166 ESGAVPVEAVQ-------AGAVVAL---------NPAKKERRSRWSTTKSFVPGMPTILPADLTE 214

  Fly    66 QQQQQSTQSIADYLAQL-LKD--RK-QLAAF-------------PNVFTHVERLLDEEIARVR-- 111
            .|:..       ||.|| ::|  || :||.|             |....:.:||...|:.:.:
 Worm   215 DQRNA-------YLLQLEIEDATRKLRLADFGVAEGRERSPSPEPVYDANGKRLNTREVRKRQEL 272

  Fly   112 --------ASLFQINGVKKEPLTLPEPEGSVVTMNEKVYVPVREHPDFNFVGRILGPRGMTAKQL 168
                    .:|.:||...|.|.....|.   :.:::||::|..:.||.||||.::||||.|.|.|
 Worm   273 EQLRHEKIQALLKINPNFKPPADYRAPN---IRLHDKVWIPQEQFPDLNFVGLLIGPRGNTLKSL 334

  Fly   169 EQETGCKIMVRGKGSMRDKKKEDANRGKPNWEHLSDDLHVLITVEDTE--NRATVKLAQAVAEVQ 231
            |.|||.||::|||||:::.|.  .||..| ....::.||..:|..|..  .:|..|:.|.:||..
 Worm   335 EAETGAKIIIRGKGSIKEGKL--TNRLGP-MPGENEPLHAYVTGTDMNVIKKACEKIKQVIAEAT 396

  Fly   232 KLLVPQAEGEDELKKRQLMELAIINGTYRDTTAKSVAAFSCVGS--------------------- 275
            .|     ...:||:|.||.|||::|||:|.....:.|..|..||
 Worm   397 AL-----PDNNELRKLQLRELALLNGTFRPEDLANGARCSNCGSDEHKSWECPDAPNVTNQIKCT 456

  Fly   276 ----------------ASYLYPAVCDEEWRRLVAASDSRLLTSTGL------------PGLAAQI 312
                            ..|...|..|:|:..|:|..........|.            .|::|..
 Worm   457 NCGAFGHISKDCKNPKGMYASEAGMDDEYSALMAELGETPAAGAGAGGGGGGHVASAGGGISAMT 521

  Fly   313 RAPAAAPLGAPLILNPRMTVPTTAASILSAQAAPTAAFDQTGHGMIFAPYD--------YANYAA 369
            .|...||.|                   .|......|....|.|   ..|.        :.|...
 Worm   522 GAGGEAPGG-------------------GAGGRGGGAHGGAGRG---GGYQGGRGGGRGFQNPRD 564

  Fly   370 LAGNPLLTEYADHSGAIKQQRRLATNREHPY------------QRATVGVPAKPAG 413
            |.|.|        .|..:||::...:.:|.|            .:...|.||.|.|
 Worm   565 LFGPP--------KGEEEQQQQANASMQHGYYDHYQQYAYPNQYQQPYGAPAPPGG 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
how	NP_001262822.1	STAR_dimer	75..122	CDD:435414	17/73 (23%)
		KH-I_HOW	132..236	CDD:411894	41/105 (39%)
sfa-1	NP_503033.1	MSL5	185..422	CDD:227503	80/254 (31%)
		PTZ00368	<427..>471	CDD:173561	4/43 (9%)