DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment how and gld-1

DIOPT Version :9

Sequence 1:NP_001262822.1 Gene:how / 42596 FlyBaseID:FBgn0264491 Length:418 Species:Drosophila melanogaster
Sequence 2:NP_492143.1 Gene:gld-1 / 172532 WormBaseID:WBGene00001595 Length:463 Species:Caenorhabditis elegans


Alignment Length:330 Identity:149/330 - (45%)
Similarity:199/330 - (60%) Gaps:24/330 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 VPMTPQHLTPQQQQQS-----------TQSIADYLAQLLKDRKQLAAFPNVFTHVERLLDEEIAR 109
            :|.||.........:|           .::..:|||.|:|::|.|..||::|::||||||:||.|
 Worm   116 LPATPMSYGKSSMDKSLFSPTATEPIEVEATVEYLADLVKEKKHLTLFPHMFSNVERLLDDEIGR 180

  Fly   110 VRASLFQINGVKKEPLTLPEPEGSVVTMNEKVYVPVREHPDFNFVGRILGPRGMTAKQLEQETGC 174
            ||.:|||....:.|   ||||.|.::::.||:|||..|:||:|||||||||||||||||||:|||
 Worm   181 VRVALFQTEFPRVE---LPEPAGDMISITEKIYVPKNEYPDYNFVGRILGPRGMTAKQLEQDTGC 242

  Fly   175 KIMVRGKGSMRDKKKEDANRGKPNWEHLSDDLHVLITVEDTENRATVKLAQAVAEVQKLLVPQAE 239
            |||||||||||||.||.|:|||.|||||.||||||:..||||||..:||..|:.:|:|||:|..|
 Worm   243 KIMVRGKGSMRDKSKESAHRGKANWEHLEDDLHVLVQCEDTENRVHIKLQAALEQVKKLLIPAPE 307

  Fly   240 GEDELKKRQLMELAIINGTYRDTTAKSVAAFSCVGSASYLYPAVCDEEWRRLVAASDSRLLTSTG 304
            |.||||::|||||||||||||  ..||......:.:...|.|.........|::.:....|.||.
 Worm   308 GTDELKRKQLMELAIINGTYR--PMKSPNPARVMTAVPLLSPTPLRSSGPVLMSPTPGSGLPSTT 370

  Fly   305 LPGLAAQIRAPAAAPLGAPL----ILNPRMTVPTTAASILSAQAAP----TAAFDQTGHGMIFAP 361
            ..|........|:..||:.:    :|:|.|....::..:.|....|    |.:|..:..|:..:.
 Worm   371 FGGSILSPTLTASNLLGSNVFDYSLLSPSMFDSFSSLQLASDLTFPKYPTTTSFVNSFPGLFTSA 435

  Fly   362 YDYAN 366
            ..:||
 Worm   436 SSFAN 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
howNP_001262822.1 STAR_dimer 75..123 CDD:293152 24/47 (51%)
SF1_like-KH 139..260 CDD:239088 91/120 (76%)
gld-1NP_492143.1 STAR_dimer 144..190 CDD:293152 24/45 (53%)
SF1_like-KH 206..328 CDD:239088 91/121 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166621
Domainoid 1 1.000 89 1.000 Domainoid score I4962
eggNOG 1 0.900 - - E1_COG5176
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1565749at2759
OrthoFinder 1 1.000 - - FOG0001806
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11208
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1339
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.850

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