Protein Alignment how and Khdrbs2

DIOPT Version :10

• Sequence 1: NP_001262822.1
• Gene: how / 42596
• FlyBaseID: FBgn0264491
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_579852.1
• Gene: Khdrbs2 / 170843
• RGDID: 621738
• Length: 349
• Species: Rattus norvegicus
• Alignment Length: 385
• Identity: 113/385 - (29%)
• Similarity: 170/385 - (44%)
• Gaps: 102/385 - (26%)

  Fly    78 YLAQLLKDRKQLAAFPNVFTHVERLLDEEIARVRASLFQINGVK--KEPLTLPEPEGSVVTMNEK 140
            ||.:|:.::..|.  |: |.|..|||.|||.:.:.|    :|.|  :|...|.......:.::|:
  Rat     6 YLPELMAEKDSLD--PS-FVHASRLLAEEIEKFQGS----DGRKEDEEKKYLDVISNKNIKLSER 63

  Fly   141 VYVPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDANR--GKPNWEHLS 203
            |.:||:::|.|||||::|||||.:.|:|::|||.|:.:.||||||||.||:..|  |:..:.|||
  Rat    64 VLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLS 128

  Fly   204 DDLHVLITVEDTENRATVKLAQAVAEVQKLLVPQAEGEDELKKRQLMELAIINGTYRDTTAKSVA 268
            |:|||||.|......|..:::.|:.|::|.|||  :..||:::.||.||:.:||:......:.:.
  Rat   129 DELHVLIEVFAPPGEAYSRMSHALEEIKKFLVP--DYNDEIRQEQLRELSYLNGSEESGRGRGIR 191

  Fly   269 AFSCVGSASYLYPAVCDEEWRRLVAASDSRLLTSTGLPGLAAQIRAPAAAPLGAPLILNPRMT-- 331
            ....                 |:...:.||        |....:..|.....|   :|.||.|
  Rat   192 GRGI-----------------RITPTAPSR--------GRGGAVPPPPPPGRG---VLTPRGTTV 228

  Fly   332 ------VPTTAASILSAQAAPTAA-------------------FDQTGHGMIFAPYDYANYAALA 371
                  ||..|..:.:.:|..|||                   :|. |:|   ..||...|.|.
  Rat   229 TRGALPVPPVARGVPTPRARGTAAVPGYRAPPPPAPEAYEEYGYDD-GYG---GEYDDQTYEAY- 288

  Fly   372 GNPLLT------EYADHSGAIKQQR---------------------RLATN--REHPYQR 402
            .|..:|      ||.|:...:.:..                     |.|..  |||||.|
  Rat   289 DNSYVTPTQSVPEYYDYGHGVNEDAYDSYAPEEWTTTRSSLKAPPPRSARGGYREHPYGR 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
how	NP_001262822.1	STAR_dimer	75..122	CDD:435414	16/45 (36%)
		KH-I_HOW	132..236	CDD:411894	48/105 (46%)
Khdrbs2	NP_579852.1	Qua1	5..57	CDD:465079	18/57 (32%)
		KH-I_KHDRBS2	54..171	CDD:411897	52/118 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..263		17/109 (16%)
		Sam68-YY	271..321	CDD:465182	12/54 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..349		8/29 (28%)