DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment how and KHDRBS3

DIOPT Version :9

Sequence 1:	NP_001262822.1	Gene:	how / 42596	FlyBaseID:	FBgn0264491	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_006549.1	Gene:	KHDRBS3 / 10656	HGNCID:	18117	Length:	346	Species:	Homo sapiens

Alignment Length:	354	Identity:	106/354 - (29%)
Similarity:	167/354 - (47%)	Gaps:	45/354 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 YLAQLLKDRKQLAAFPNVFTHVERLLDEEIARVRASLFQINGVKKEPLTLPEPEGSVVTMNEKVY 142
            ||.:|:.::..|.  |: |||..||:::||.:     ||....|.|...:.......:.:.:||.
Human     5 YLPELMAEKDSLD--PS-FTHALRLVNQEIEK-----FQKGEGKDEEKYIDVVINKNMKLGQKVL 61

  Fly   143 VPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDANR--GKPNWEHLSDD 205
            :||::.|.|||||::|||||.:.|:|::||..|:.:.||||||||.||:..|  |:..:.||:||
Human    62 IPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDD 126

  Fly   206 LHVLITVEDTENRATVKLAQAVAEVQKLLVPQAEGEDELKKRQLMELAIINGTYRDTTAKSVAAF 270
            |||||.|......|..::..|:.|::|.|:|  :..||:::.||.||..:||...:.....|...
Human   127 LHVLIEVFAPPAEAYARMGHALEEIKKFLIP--DYNDEIRQAQLQELTYLNGGSENADVPVVRGK 189

  Fly   271 SCVGSASYLYPAVCDEEWRRLVAASDSRLLTSTGLP---GLAAQIRAPAAAPLGAPLILNPRMT- 331
            ..:.:.....||:  ...|..|.|....::...|.|   |:.: .|.|.:...|   :|.||..
Human   190 PTLRTRGVPAPAI--TRGRGGVTARPVGVVVPRGTPTPRGVLS-TRGPVSRGRG---LLTPRARG 248

  Fly   332 VPTTAASILSAQAAPTAAFDQT--------GHGMIFAPYDYANYAALAGNPLLT--EYADHSGAI 386
            ||.|     ..:..|.....:|        |:|..:....|.:|......|..:  :|.|:...:
Human   249 VPPT-----GYRPPPPPPTQETYGEYDYDDGYGTAYDEQSYDSYDNSYSTPAQSGADYYDYGHGL 308

  Fly   387 KQQ------RRLATNREH--PYQRATVGV 407
            .::      :...||..|  |..|...||
Human   309 SEETYDSYGQEEWTNSRHKAPSARTAKGV 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
how	NP_001262822.1	STAR_dimer	75..123	CDD:293152	15/44 (34%)
how	NP_001262822.1	SF1_like-KH	139..260	CDD:239088	56/122 (46%)
KHDRBS3	NP_006549.1	Involved in homodimerization. /evidence=ECO:0000269\|PubMed:26758068	1..160		64/164 (39%)
		Qua1	4..53	CDD:406639	16/55 (29%)
		KH-I_KHDRBS3	48..160	CDD:411898	48/113 (42%)
		Interaction with SIAH1. /evidence=ECO:0000269\|PubMed:15163637	212..251		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..267		14/62 (23%)
		Sam68-YY	266..320	CDD:406871	7/53 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..346		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810