DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and MSS116

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_010480.1	Gene:	MSS116 / 851775	SGDID:	S000002602	Length:	664	Species:	Saccharomyces cerevisiae

Alignment Length:	539	Identity:	156/539 - (28%)
Similarity:	278/539 - (51%)	Gaps:	70/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 QEDEDEEEPVPAKKTKLLPNKSKAQNGKPAKDDEPFTVESSLAALDYRDSDDRSFASLKGAVSEA 197
            :||:||........:||: :..|..|.|..      |::|.|.               :|.:.:.
Yeast    74 REDDDEVHFDKTTFSKLI-HVPKEDNSKEV------TLDSLLE---------------EGVLDKE 116

  Fly   198 TLRAIKEMGFTEMTEIQSKSLTPLL--KGRDLVGAAQTGSGKTLAFLIPAVELINKLRFMPRNGT 260
            ..:||..|.|..:|.:|.|::.|:|  :..|::..|:||:|||.|||||..:.:...:|..:...
Yeast   117 IHKAITRMEFPGLTPVQQKTIKPILSSEDHDVIARAKTGTGKTFAFLIPIFQHLINTKFDSQYMV 181

  Fly   261 GVIIISPTRELSMQTFGVLKELMAHHHHTYGL-------VMGGSNRQVESEKLGK-GINILVATP 317
            ..:|::|||:|::|....:|::   |...|||       ::||::.:....|:.| ..||::|||
Yeast   182 KAVIVAPTRDLALQIEAEVKKI---HDMNYGLKKYACVSLVGGTDFRAAMNKMNKLRPNIVIATP 243

  Fly   318 GRLLDHLQNSPDFLYKNLQCLIIDEVDRILEIGFEEELKQIINLLPKRR-------QTMLFSATQ 375
            |||:|.|:...:..::.:...::||.||:|||||.::|:.|..:|.::.       :|:|||||.
Yeast   244 GRLIDVLEKYSNKFFRFVDYKVLDEADRLLEIGFRDDLETISGILNEKNSKSADNIKTLLFSATL 308

  Fly   376 TARIEAL-SKLALKSEPIYVGVHDNQDTATVDGLEQGYIVCPSEKRLLVLFT---FLKKNRKK-- 434
            ..:::.| :.:..|.|.:::...|..:....:.::|..::  |||....:|.   .:||..|:
Yeast   309 DDKVQKLANNIMNKKECLFLDTVDKNEPEAHERIDQSVVI--SEKFANSIFAAVEHIKKQIKERD 371

  Fly   435 ---KVMVFFSSCMSVKYHHELFNYI------DLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCT 490
               |.::|   ..:||:...|.:.:      |||:...|||..|.|||:...:|...|||||:||
Yeast   372 SNYKAIIF---APTVKFTSFLCSILKNEFKKDLPILEFHGKITQNKRTSLVKRFKKDESGILVCT 433

  Fly   491 DVAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEELGFLRYLKAAKVP 555
            ||.|||:|.|.|..::|...|.:...||||:||||| ||..|.::|.:..:||.|:|.|:.||..
Yeast   434 DVGARGMDFPNVHEVLQIGVPSELANYIHRIGRTAR-SGKEGSSVLFICKDELPFVRELEDAKNI 497

  Fly   556 LNEFEFSWQKIADIQLQLEKLIAKNYFLNQSAKEAFKSYVRAYDSHQLKQIFNVNTLDLQAVAKS 620
            :...:..::...:|:.::.:.:.:.   .:...:...|.:.:|.|...:..|:...: |..:|.:
Yeast   498 VIAKQEKYEPSEEIKSEVLEAVTEE---PEDISDIVISLISSYRSCIKEYRFSERRI-LPEIAST 558

  Fly   621 FGFLV-PPVVDLKVGAAKR 638
            :|.|: .|  .||:..::|
Yeast   559 YGVLLNDP--QLKIPVSRR 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	144/486 (30%)
		DEADc	187..394	CDD:238167	69/224 (31%)
		HELICc	408..537	CDD:238034	53/142 (37%)
		DUF4217	569..627	CDD:290667	9/58 (16%)
MSS116	NP_010480.1	SrmB	76..579	CDD:223587	155/537 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0342
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S302
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003394
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.720