DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and ddx10

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001096151.1	Gene:	ddx10 / 613047	XenbaseID:	XB-GENE-985914	Length:	852	Species:	Xenopus tropicalis

Alignment Length:	544	Identity:	213/544 - (39%)
Similarity:	331/544 - (60%)	Gaps:	25/544 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 SEDDDQQEDEDEEEPVPAKKTKLLPNKSKAQNGKPAKDDEPFTVESSLAALDYRDSDDRSFASLK 191
            |.:|..:..|..::....||.|.  ...:.||.||....|    :.::..|:.|.|:..:...:|
Frog    16 SRNDPVKNFEKWKKKYSKKKEKC--KSHRKQNKKPEWQVE----KETITRLEQRYSEINTSEIVK 74

  Fly   192 GA---VSEATLRAIKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELINKLR 253
            .:   :|:.|||.:.|..:...||||.:::...|:|:|::|||:|||||||||:|||:|.:.:.:
Frog    75 FSDFPLSKKTLRGLVEGQYRLPTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFIIPALECLYRQQ 139

  Fly   254 FMPRNGTGVIIISPTRELSMQTFGVLKELMAHHHHTYGLVMGGSNRQVESEKLGKGINILVATPG 318
            :...:|.||:||||||||:.|||.||:::..:|..:.|||:||.:.:.|:..:.: .|||:.|||
Frog   140 WTSDDGLGVLIISPTRELAYQTFEVLRKVGRNHEFSAGLVIGGKDLKQETACIHR-TNILICTPG 203

  Fly   319 RLLDHLQNSPDFLYKNLQCLIIDEVDRILEIGFEEELKQIINLLPKRRQTMLFSATQTARIEALS 383
            |||.|:..:..|...|||.|::||.||||::||.:.:..|:..|||:|||:|||||||..::.|:
Frog   204 RLLQHMDETSTFHASNLQMLVLDEADRILDMGFADTMNAIVENLPKKRQTLLFSATQTKSVKDLA 268

  Fly   384 KLALKSEPIYVGVHDNQDTATVDGLEQGYIVCPSEKRLLVLFTFLKKNRKKKVMVFFSSCMSVKY 448
            :|:|| :|.||.||:|...:|...|||.|:||..::::.:|::|::.:.|||.:||||||..|:|
Frog   269 RLSLK-DPEYVWVHENAKFSTPATLEQNYVVCELQQKINLLYSFIRNHLKKKSIVFFSSCKEVQY 332

  Fly   449 HHELFNYI--DLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCTDVAARGLDIPQVDWIVQYDPP 511
            ....|..:  .:||..:||||:|.||...:..|...:|.:|..||:||||||.|.|:|::|.|.|
Frog   333 LFRAFCRLRPGIPVLVLHGKQQQMKRMEVYNDFIRKKSAVLFATDIAARGLDFPAVNWVLQLDCP 397

  Fly   512 DDPREYIHRVGRTARGSGTSGHALLLMRPEEL-GFLRYLKAAKVPLNEFEFSWQKIADIQLQLEK 575
            :|...||||||||||.. ..|.|||::.|.|: |..:.|:..|||:||.:.:.:|:.|:|.:||.
Frog   398 EDANTYIHRVGRTARYK-EGGEALLVLLPSEVKGMFKQLEEKKVPINEIKINPEKLMDVQGRLEA 461

  Fly   576 LIAKNYFLNQSAKEAFKSYVRAYDSHQLKQIFNVNTLDLQAVAKSFGFLVPPVVDLKVGAAKRER 640
            .:|:...|.::|:..|.||:|:....:.|::|:|..|.|...|:|.|..|.|.|...:.|...:.
Frog   462 FLAQEQDLKETAQRCFVSYLRSVYLMKNKEVFDVFKLPLTQYAQSLGLAVAPRVRFLLKAQNAQS 526

  Fly   641 PEKRVGGGGFGFYKKMNEGSASKQ 664
            ..          ..|.:.|:||.|
Frog   527 TS----------VSKDDPGTASDQ 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	199/485 (41%)
		DEADc	187..394	CDD:238167	94/209 (45%)
		HELICc	408..537	CDD:238034	60/130 (46%)
		DUF4217	569..627	CDD:290667	19/57 (33%)
ddx10	NP_001096151.1	SrmB	52..564	CDD:223587	203/506 (40%)
ddx10	NP_001096151.1	60KD_IMP	<704..798	CDD:321001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D218522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920