DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and ddx10

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_001922220.1	Gene:	ddx10 / 569118	ZFINID:	ZDB-GENE-071022-2	Length:	864	Species:	Danio rerio

Alignment Length:	517	Identity:	201/517 - (38%)
Similarity:	315/517 - (60%)	Gaps:	12/517 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 DDDQQEDEDEEEPVPAKKTKLLPNKSKAQNGKPAKDDEPFTVESSLAALD-YRDSDDRSFASLKG 192
            ||..:..|..::.....|||:    .::|..|..|.|.....|:....:| |.:.:.:.......
Zfish    14 DDPVKNFEKWKKKYAKTKTKV----KRSQKSKVKKRDWEVERENIKKLVDKYSEINPKEAVKFSD 74

  Fly   193 -AVSEATLRAIKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELINKLRFMP 256
             .:|:.||:.:.|..:.:.||||.:::...|:|||::|||:||||||||||||.:|.:.:.::..
Zfish    75 FPLSKKTLKGLLEAQYRQPTEIQRQTIGFALQGRDVLGAAKTGSGKTLAFLIPVLECLYREQWTA 139

  Fly   257 RNGTGVIIISPTRELSMQTFGVLKELMAHHHHTYGLVMGGSNRQVESEKLGKGINILVATPGRLL 321
            .:|.|.:||||||||:.|||.||:::..:|..:.|||:||.:.:.||||:.: .||::.||||||
Zfish   140 MDGLGALIISPTRELAYQTFEVLRKVGKNHEFSAGLVIGGKDLKDESEKIHR-TNIIICTPGRLL 203

  Fly   322 DHLQNSPDFLYKNLQCLIIDEVDRILEIGFEEELKQIINLLPKRRQTMLFSATQTARIEALSKLA 386
            .|:..:..|...:|..|::||.||||::||.:.|..|:..|||.|||:|||||||..::.|::|:
Zfish   204 QHMDETATFHASDLHMLVLDEADRILDMGFADTLNAIVENLPKSRQTLLFSATQTRSVKDLARLS 268

  Fly   387 LKSEPIYVGVHDNQDTATVDGLEQGYIVCPSEKRLLVLFTFLKKNRKKKVMVFFSSCMSVKYHHE 451
            || :|.||.||:....:|...|||.|:||...:::.:|::||:.:.:||::|||:.|..|:|...
Zfish   269 LK-DPEYVWVHEQAKFSTPATLEQNYVVCELHQKVNMLYSFLRSHLQKKIIVFFACCKEVQYLFR 332

  Fly   452 LFNYI--DLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCTDVAARGLDIPQVDWIVQYDPPDDP 514
            :|..:  .:.|.::||||:|.||...:..|....|.:|..||:||||||.|.|:|::|:|.|:|.
Zfish   333 IFCRLRPGISVLALHGKQQQMKRVEVYNDFVRKTSAVLFATDIAARGLDFPAVNWVLQFDCPEDA 397

  Fly   515 REYIHRVGRTARGSGTSGHALLLMRP-EELGFLRYLKAAKVPLNEFEFSWQKIADIQLQLEKLIA 578
            ..||||||||||.. ..|.|||::.| ||.|.:..|:..|||:|:.:.:.:|:..:|.:||..:|
Zfish   398 NTYIHRVGRTARYK-EGGEALLVLLPSEEKGMISQLQEKKVPINKIQVNPEKLMSVQQKLEAFLA 461

  Fly   579 KNYFLNQSAKEAFKSYVRAYDSHQLKQIFNVNTLDLQAVAKSFGFLVPPVVDLKVGAAKRER 640
            :.....:.|:..|.||:|:....:.|.:|:|..|.|...|.|.|..|.|.|...:.|.::.|
Zfish   462 QEKEQKERAQRCFVSYLRSVYLMKNKDVFDVLQLKLPEYAMSLGLAVAPRVRFLLKAQQQRR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	188/459 (41%)
		DEADc	187..394	CDD:238167	93/207 (45%)
		HELICc	408..537	CDD:238034	57/130 (44%)
		DUF4217	569..627	CDD:290667	18/57 (32%)
ddx10	XP_001922220.1	DEADc	72..276	CDD:238167	94/205 (46%)
		DEXDc	90..275	CDD:214692	89/186 (48%)
		HELICc	289..419	CDD:238034	57/130 (44%)
		DUF4217	452..511	CDD:290667	18/58 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D218522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920