DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pit and ddx1

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001184253.1	Gene:	ddx1 / 556790	ZFINID:	ZDB-GENE-041001-215	Length:	740	Species:	Danio rerio

Alignment Length:	387	Identity:	95/387 - (24%)
Similarity:	166/387 - (42%)	Gaps:	100/387 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 LVGAAQTGSGKTLAFLIPAVELINKLRFMPRNGTGVIIISPTRELSMQTFG------------VL 279
            :|.::||||.|        |..:......||    .:||.|::||:.||..            .|
Zfish   266 VVKSSQTGSAK--------VTQVKSSSNAPR----ALIIEPSKELAEQTLNNVNQFKKYVDNPKL 318

  Fly   280 KELMAHHHHTYGLVMGGSNRQVESEKLGKGINILVATPGRLLDHLQNSPDFLYKNLQCLIIDEVD 344
            :||         |::||...:.:...|..|::|:|.|||| ||.|.::.......::.|::||.|
Zfish   319 REL---------LIIGGVAAKEQLNVLESGVDIVVGTPGR-LDDLISTGKLDLSQVRFLVLDECD 373

  Fly   345 RILEIGFEEELKQIINLLP------KRRQTMLFSAT-QTARIEALSK--------LALKSEP--- 391
            .:|..|..:.:.:|.|.:|      ||.|.::.||| .:..::.||:        :.||.|.
Zfish   374 GLLSAGNTDFIMRIYNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVP 438

  Fly   392 -----IYVGVHDNQDTA-------------------TVDGLEQGYIVCPSEKRLLVLFTF--LKK 430
                 :.|.|:...|..                   |..|.....:...:.|.|...:|.  :|:
Zfish   439 ETVHHVVVTVNPKNDKLWERLGKNHIRTDEVHAKDDTRPGANSPEMWSEAIKILKGEYTVRAIKE 503

  Fly   431 NRKKKVMVFFSS---CMSVKYH------------HELFNYIDLPVTSIHGKQKQTKRTTTFFQFC 480
            ::..:.::|..:   |.:::.:            |: |:.:     .:||.:|..:|.....:|.
Zfish   504 HKMDQAIIFCRTKIDCDNMEQYFIKQGGGPDKKGHQ-FSCV-----CLHGDRKPNERKYNLERFK 562

  Fly   481 NAESGILLCTDVAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEE 542
            ..|...|:||||||||:|:..|.:::....||:...|:||:||..| :...|.|:.|:..|:
Zfish   563 KQEVKFLICTDVAARGIDVRGVPYVINVTLPDEKENYVHRIGRVGR-ADRMGLAISLVAMEK 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	95/387 (25%)
		DEADc	187..394	CDD:238167	53/201 (26%)
		HELICc	408..537	CDD:238034	35/145 (24%)
		DUF4217	569..627	CDD:290667
ddx1	NP_001184253.1	SrmB	1..>62	CDD:223587
		P-loop_NTPase	4..>70	CDD:304359
		SPRY_DDX1	93..245	CDD:293933
		DEXDc	238..439	CDD:214692	53/194 (27%)
		P-loop_NTPase	266..426	CDD:304359	50/181 (28%)
		Helicase_C	493..609	CDD:278689	31/122 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010