Protein Alignment pit and ddx18

DIOPT Version :10

• Sequence 1: NP_524446.3
• Gene: pit / 42595
• FlyBaseID: FBgn0266581
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_001016776.1
• Gene: ddx18 / 549530
• XenbaseID: XB-GENE-6085268
• Length: 640
• Species: Xenopus tropicalis
• Alignment Length: 683
• Identity: 403/683 - (59%)
• Similarity: 513/683 - (75%)
• Gaps: 51/683 - (7%)

  Fly     3 IREKLLMKKIVKREKMKKELSQKKGNKNAQKQEPPKQN-GNKPSKKPEKLSKKHVAKDEDDDLEE 66
            ::.|||.:||.|:       ::|..|:|.:::|....: .:|.:::.|.::::....|..:::||
 Frog     4 LQMKLLRRKIQKK-------NEKIRNRNRERREREALSLASKCAEEAEGVAEEREEGDGVNNVEE 61

  Fly    67 DFQEAPLPKKKQQKQPP----KKQQIQVANSDSESDDDEQEDEADEDSDLDEVAEVDEEDVDSGS 127
            ..|...: ...:..|||    ||::...|.::. :|..:.:.||.|.||.:...|         :
 Frog    62 TQQNTSV-DVGETSQPPTAKKKKKRKNAAKAEG-ADAKKAKQEAPEGSDQESKCE---------N 115

  Fly   128 EDDDQQEDEDEEEPVPAKKTKLLPNKSKAQNGKPAKDDEPFTVESSLAALDYRDSDDRSFASLKG 192
            ..:.:.|:|.|||                       :|.| |:...|...    .:|.:|:||..
 Frog   116 HVETKAEEEAEEE-----------------------EDGP-TLPMGLTGA----FEDTAFSSLAE 152

  Fly   193 AVSEATLRAIKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELINKLRFMPR 257
            :|:|.||||:.|||||.|||||.|::.|||:|||::.||:|||||||||||||:||:.||:||||
 Frog   153 SVNENTLRAVTEMGFTHMTEIQHKAIRPLLEGRDVLAAARTGSGKTLAFLIPAIELVYKLKFMPR 217

  Fly   258 NGTGVIIISPTRELSMQTFGVLKELMAHHHHTYGLVMGGSNRQVESEKLGKGINILVATPGRLLD 322
            |||||:|:||||||:|||:||||||||||.||:||:||||||..|::||..|:||:|||||||||
 Frog   218 NGTGVLILSPTRELAMQTYGVLKELMAHHVHTFGLIMGGSNRSAEAQKLANGVNIVVATPGRLLD 282

  Fly   323 HLQNSPDFLYKNLQCLIIDEVDRILEIGFEEELKQIINLLPKRRQTMLFSATQTARIEALSKLAL 387
            |:||:|.|:|||||||:|||.|||||:|||:|:|||||||||||||||||||||.::|.|::::|
 Frog   283 HMQNTPGFMYKNLQCLVIDEADRILEVGFEQEMKQIINLLPKRRQTMLFSATQTRKVEDLARISL 347

  Fly   388 KSEPIYVGVHDNQDTATVDGLEQGYIVCPSEKRLLVLFTFLKKNRKKKVMVFFSSCMSVKYHHEL 452
            |.||:||||.|:::|||||||||||:|||||||.|:||||||||||||:|||||||||||||:||
 Frog   348 KKEPLYVGVDDHKETATVDGLEQGYVVCPSEKRFLLLFTFLKKNRKKKMMVFFSSCMSVKYHYEL 412

  Fly   453 FNYIDLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCTDVAARGLDIPQVDWIVQYDPPDDPREY 517
            .|||||||.:||||||||||||||||||||||||||||||||||||||:|||||||||||||:||
 Frog   413 LNYIDLPVMAIHGKQKQTKRTTTFFQFCNAESGILLCTDVAARGLDIPEVDWIVQYDPPDDPKEY 477

  Fly   518 IHRVGRTARGSGTSGHALLLMRPEELGFLRYLKAAKVPLNEFEFSWQKIADIQLQLEKLIAKNYF 582
            ||||||||||....|||||::||||||||||||.|||||:||||||.||:|||.||||||.|||:
 Frog   478 IHRVGRTARGIDGRGHALLILRPEELGFLRYLKQAKVPLSEFEFSWSKISDIQTQLEKLIEKNYY 542

  Fly   583 LNQSAKEAFKSYVRAYDSHQLKQIFNVNTLDLQAVAKSFGFLVPPVVDLKVGAAKRERPEKRVGG 647
            |::||:||:|:|:||||||..||||:||||:|..||.||||.|||.|||.|.::..:|.:||.||
 Frog   543 LHKSAQEAYKAYIRAYDSHSHKQIFDVNTLNLPKVAISFGFQVPPFVDLNVNSSGGKRLQKRGGG 607

  Fly   648 GGFGFYKKMNEGSASKQRHFKQVNRDQAKKFMR 680
            ||||:.|..|:..|...:|..:..|...::|.|
 Frog   608 GGFGYQKSNNQHKAKIFKHINKRGRGDGRQFTR 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_524446.3	DEADc_DDX18	198..395	CDD:350700	146/196 (74%)
		SF2_C_DEAD	408..537	CDD:350174	114/128 (89%)
		DUF4217	570..627	CDD:464056	39/56 (70%)
ddx18	NP_001016776.1	DEADc_DDX18	158..355	CDD:350700	146/196 (74%)
		SF2_C_DEAD	368..498	CDD:350174	115/129 (89%)
		DUF4217	530..587	CDD:464056	39/56 (70%)