Protein Alignment pit and DDX56

DIOPT Version :9

• Sequence 1: NP_001287459.1
• Gene: pit / 42595
• FlyBaseID: FBgn0266581
• Length: 680
• Species: Drosophila melanogaster
• Sequence 2: NP_061955.1
• Gene: DDX56 / 54606
• HGNCID: 18193
• Length: 547
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 151/576 - (26%)
• Similarity: 247/576 - (42%)
• Gaps: 116/576 - (20%)

  Fly   181 DSDDRSFASLKGAVSEATLRAIKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPA 245
            ||:...|..:  .:....|:|:.::|::..|.||.|::...|:|:||:..|:||||||.|:.||.
Human     3 DSEALGFEHM--GLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPM 65

  Fly   246 VELINKLRFMPRNGTGVI--------IISPTRELSMQTFGVLKELMAHHHHTYGLVM------GG 296
            ::|:     :.|..||.:        ::.||:||:.|...::::|..:......:..      ..
Human    66 LQLL-----LHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSAAEDSV 125

  Fly   297 SNRQVESEKLGKGINILVATPGRLLDHLQNSPDFLYKNLQCLIIDEVDRILEIGFEEELKQIINL 361
            |.|.|..||    .:::|.||.|:|.|||.....|..:|:.|::||.|.:...|||||||.::..
Human   126 SQRAVLMEK----PDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEELKSLLCH 186

  Fly   362 LPKRRQTMLFSATQTARIEALSKLALKSEPIYVGVHDNQDTATVDGLEQGYIVCPSEK-RLLVLF 425
            ||:..|..|.|||....::||.:|.|.: |:.:.:.::| ....|.|:|..:||.:|: :.|:|:
Human   187 LPRIYQAFLMSATFNEDVQALKELILHN-PVTLKLQESQ-LPGPDQLQQFQVVCETEEDKFLLLY 249

  Fly   426 TFLKKNRKKKVMVFFSSCMSVKYHHELF-NYIDLPVTSIHGKQKQTKRTTTFFQFCNAESGILLC 489
            ..||.:..:...:.|.:.:...|...|| ....:|...::|:.....|.....||.......::.
Human   250 ALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIA 314

  Fly   490 TDV---------------------------AARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARG 527
            ||.                           .|||:|...|..::.:|.|..|..||||.|||||
Human   315 TDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTAR- 378

  Fly   528 SGTSGHALLLMRPEE---LGFLRYLKAA--KVPLNEFEFSWQKIADIQLQLEKLIAKNYFLNQSA 587
            :...|..|..:.|.|   ||.:..|.:.  :.|:         :...|.::|::....|....:.
Human   379 ANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPI---------LLPYQFRMEEIEGFRYRCRDAM 434

  Fly   588 KEAFKSYVR----------AYDSHQLKQIFNVNTLDLQ----------AVAKSF-----GFLVPP 627
            :...|..:|          ...|.:||..|..|..|||          ||.|..     .:||||
Human   435 RSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPP 499

  Fly   628 VVDLKVGAAKRERPEKRVGGGGFGFYKKMNEGSASKQRHFKQVN-----RDQAKKF 678
            .:...|      ||.|:         :|....|..|.:..|..|     :.:.|||
Human   500 ALRGLV------RPHKK---------RKKLSSSCRKAKRAKSQNPLRSFKHKGKKF 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	146/568 (26%)
		DEADc	187..394	CDD:238167	70/220 (32%)
		HELICc	408..537	CDD:238034	39/157 (25%)
		DUF4217	569..627	CDD:290667	18/82 (22%)
DDX56	NP_061955.1	Q motif	7..35		6/29 (21%)
		SrmB	9..513	CDD:223587	141/541 (26%)
		DEADc_DDX56	14..220	CDD:350719	69/215 (32%)
		DEAD box	166..169		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..547		11/44 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010