DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and ddx1

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001011133.1	Gene:	ddx1 / 496549	XenbaseID:	XB-GENE-969096	Length:	740	Species:	Xenopus tropicalis

Alignment Length:	645	Identity:	117/645 - (18%)
Similarity:	204/645 - (31%)	Gaps:	323/645 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 GAVSEATLRAIKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELI------- 249
            |.::|.. :|::||.:...|:||::|:..:|.|.|::.||:||||||.||.||.::::
Frog     8 GVMAEIA-QAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETLKDQ 71

  Fly   250 ----------------------------------------------------------------- 249

Frog    72 QEGKKGKTSVKTGSTVLNKWQMNPYDRGSSFAIGSDGLCCQSREIKEWHGCRSTRGVNKGKYYYE 136

  Fly   250 ---------------------------------------NK------------------------ 251
                                                   ||
Frog   137 VSCHDQGLCRVGWSTLQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYIDIDNG 201

  Fly   252 ---------------------------------------------LRFMPRNG------------ 259
                                                         .:|.|::|
Frog   202 TVKYSKNGKDLGLAFQIPAHLKNQAVFASCVLKNAELKFNFGEEDFKFPPKDGFVALSKAPDGHV 266

  Fly   260 -----TG---------------VIIISPTRELSMQTFG------------VLKELMAHHHHTYGL 292
                 ||               .:||.|:|||:.||..            .|:||         |
Frog   267 VKSQNTGSAQVSQAKNLPNAPKALIIEPSRELAEQTLNNVKQFKKYVDSPKLREL---------L 322

  Fly   293 VMGGSNRQVESEKLGKGINILVATPGRLLDHLQNSPDFLYKNLQCLIIDEVDRILEIGFEEELKQ 357
            ::||...:.:...|..|::|:|.|||| :|.|.::.......::.|::||.|.:|..|:.:.:.:
Frog   323 IIGGVAAKEQLTLLENGVDIVVGTPGR-IDDLISTGKLNLSQVRFLVLDEADGLLSQGYSDFINR 386

  Fly   358 IINLLP------KRRQTMLFSAT-QTARIEALSK--------LALKSE------------PIYV- 394
            |...:|      ||.|.::.||| .:..::.||:        :.||.|            |:..
Frog   387 IHGQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPETVHHVVVPVNPK 451

  Fly   395 ----------------GVHDNQDT-----------ATVDGLEQGYIVCPSEKRLLVLFTFLKKNR 432
                            ||||..:|           ..:..|:..|.|           ..:|:::
Frog   452 KDKQWERLGKNHIRTDGVHDKDNTRPGGNSAEMWSEAIKVLKGEYTV-----------RAIKEHK 505

  Fly   433 KKKVMVFFSS---CMSVKYH------------HELFNYIDLPVTSIHGKQKQTKRTTTFFQFCNA 482
            ..:.::|..:   |.:::.:            |: |:.:     .:|..:|..:|.....:|...
Frog   506 MDQAIIFCRTKLDCDNMEQYFIQQGGGPDKKGHQ-FSCV-----CLHSDRKPQERKHNLERFKKC 564

  Fly   483 ESGILLCTDVAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEE 542
            |...|:||||||||:||..|.:::....||:.:.|:||:||..|.. ..|.|:.|:..|:
Frog   565 EVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAE-RMGLAISLVAAEK 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	117/645 (18%)
		DEADc	187..394	CDD:238167	75/452 (17%)
		HELICc	408..537	CDD:238034	35/143 (24%)
		DUF4217	569..627	CDD:290667
ddx1	NP_001011133.1	Interaction with dsRNA. /evidence=ECO:0000250\|UniProtKB:Q91VR5	1..448		74/450 (16%)
		DEAD-like_helicase_N	4..>64	CDD:391939	24/56 (43%)
		SPRY_DDX1	93..246	CDD:293933	2/152 (1%)
		DEADc_DDX1	264..430	CDD:350696	42/175 (24%)
		SrmB	284..>624	CDD:223587	86/368 (23%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	370..373		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010