DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and ddx51

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001003864.1	Gene:	ddx51 / 445387	ZFINID:	ZDB-GENE-040927-28	Length:	652	Species:	Danio rerio

Alignment Length:	654	Identity:	174/654 - (26%)
Similarity:	297/654 - (45%)	Gaps:	116/654 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 REKLLMKKIVKREKMKKELSQKKGNKNAQKQEPPKQNGNKPSKKPEKL--SKKHVAKDED----D 62
            |.|.|:.|:.|:.|.:.:.|.    .|..|:|..:|:..:..|:..||  :|..:.|.|.    |
Zfish    23 RSKALLAKLQKQVKARGQQSV----SNTPKEEEEQQDDKEHKKRKHKLQETKGKIKKSESVQNTD 83

  Fly    63 DLEEDFQEAPLPKKKQQKQPPKKQQIQVANSDSESDDDEQED--EADEDSDLDEVAEVDEEDVDS 125
            ..||  .::.:.|||::|:....:.:.|...::||::::..|  .....|.:...||..|| :.|
Zfish    84 PTEE--ADSSVKKKKKRKKSLSTEDVIVKIEENESENEKSVDITGPTPSSPVQFKAEKAEE-LTS 145

  Fly   126 GSEDDDQQEDEDEEEPVPAKKTKLLPNKSKAQNGKPAKDDEPFTVESSLAALDYRDSDDRSFASL 190
            .|:.:.|.....:|:.| .|..::|| :..:|.....||     ::|:|..:          :.:
Zfish   146 SSQSNYQVLGGFKEKDV-QKVKRVLP-QWLSQPDVIQKD-----IKSNLIPI----------SEV 193

  Fly   191 KGAVSEATLRAIKEMGFTEMTEIQSKSLTPLLKG--------------RDLVGAAQTGSGKTLAF 241
            .| :....||.::..|......:|::.:..:|:.              ||:..:|.|||||||||
Zfish   194 PG-ICPTLLRKLQTNGIQSFFPVQAEVIPAILESVGSGLLVGPGGYRPRDVCVSAPTGSGKTLAF 257

  Fly   242 LIPAVELINKLRFMPRNGTGVIIISPTRELSMQTFGVLKELMAHHHHTYG------LVMGGSNRQ 300
            :||.|:.::| |.:.:  ...:.:.||:||:.|...|...      :|.|      ::.|..:..
Zfish   258 VIPVVQALSK-RVVRQ--VRALAVLPTKELAQQVSNVFSA------YTEGSSLKVVMITGQKSFA 313

  Fly   301 VESEKLGK---GI-----NILVATPGRLLDHLQNSPDFLYKNLQCLIIDEVDRILEIGFEEELKQ 357
            .|...|.:   |:     :|:|||||||:||:..:..|..::|:.|||||.||:::...:..|.|
Zfish   314 AEQTALSEIRGGVSHSMADIVVATPGRLVDHINKNSSFSLQHLRFLIIDEADRMIDSMHQSWLSQ 378

  Fly   358 I--------------------------INLLPKR--RQTMLFSATQTARIEALSKLALKSEPIYV 394
            :                          .:|.|.:  .|.:|||||.|...|.|..|.|....::.
Zfish   379 VTKAVYSTPGETHTSVFRRTVPGPITAASLSPPQIPLQKLLFSATLTQNPEKLQLLDLHQPRLFS 443

  Fly   395 GVH---DN----QDTATV-DGLEQGYIVCPSEKRLLVLFTFLKKNRKKKVMVFFSSCMSVKYHHE 451
            ..|   ||    |||... .||.:.|:.|...|:.|::..||.:.:....:.|.:|....   |.
Zfish   444 STHSLTDNPAQSQDTFHFPQGLSEYYVPCTFSKKPLIILHFLLRLKFSPALCFTNSREGA---HR 505

  Fly   452 LFNYIDL----PVTSIHGKQKQTKRTTTFFQFCNAESGILLCTDVAARGLDIPQVDWIVQYDPPD 512
            |:..:.|    .|.....|....:|..|...|...:..:|:.||.||||:||..|..::.||.|.
Zfish   506 LYLLVKLFGGVEVAEFSSKLSPGERQKTLKDFEKGKIPLLISTDAAARGIDINGVKCVINYDAPQ 570

  Fly   513 DPREYIHRVGRTARGSGTSGHAL-LLMRPEELGFLRYLKAAKVP-LNEFEFSWQKIADIQLQLEK 575
            ..|.|||||||||| :|.:|.|. .|::.:|..||:.:..|..| :.:.....:.:..::.:.|:
Zfish   571 YIRTYIHRVGRTAR-AGKAGLAFTFLLKVQEKRFLKMVSDAGSPGIQKQHVHPEALKSMESRYEQ 634

  Fly   576 LIAK 579
            ::|:
Zfish   635 VLAE 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	128/464 (28%)
		DEADc	187..394	CDD:238167	69/262 (26%)
		HELICc	408..537	CDD:238034	44/133 (33%)
		DUF4217	569..627	CDD:290667	2/11 (18%)
ddx51	NP_001003864.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..145		33/128 (26%)
		P-loop_NTPase	195..439	CDD:304359	69/253 (27%)
		DEXDc	204..451	CDD:214692	67/255 (26%)
		Q motif	212..220		1/7 (14%)
		DEAD box	362..365		2/2 (100%)
		Helicase_C	475..586	CDD:278689	38/114 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010