DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and CG5589

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_649009.1	Gene:	CG5589 / 39979	FlyBaseID:	FBgn0036754	Length:	594	Species:	Drosophila melanogaster

Alignment Length:	601	Identity:	156/601 - (25%)
Similarity:	267/601 - (44%)	Gaps:	64/601 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 KKQQKQPPKKQQIQVANSDSESDDDEQEDEADEDSDLDEVAEVDEEDVDSGSEDDDQQEDEDEEE 140
            ||.:|:|..|||:|.....|:.::..:.:|:|:|.  :::.|....|.||.::...::
  Fly    18 KKSKKEPSSKQQLQPLPEVSKHEEPVKSEESDKDD--EDITEFRLLDGDSSNQPKRKK------- 73

  Fly   141 PVPAKKTKLLPNKSKAQNGKPAKDDEPFTVESSLAAL--------DYRDSDDRSFASLKGAVSEA 197
              |.|:..|.|.:.:.|  |.|::......:..:..|        |...:..|.|..|.......
  Fly    74 --PKKEKTLSPKELEIQ--KAAEEANETRKQYGIRVLGKNVPPPVDSFGTLTRDFKMLPRLQQNL 134

  Fly   198 TLRAIKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELINKLRFMPRNGTGV 262
            ..|     .|...|.||.::|..||:.|.|:..|.||||||||||.|   :||.||.....|...
  Fly   135 LSR-----NFDHPTPIQMQALPVLLQRRALMACAPTGSGKTLAFLTP---IINGLRAHKTTGLRA 191

  Fly   263 IIISPTRELSMQTFGVLKELMAHHH-HTYGLVMGGSNRQVESEKLGKGINILVATPGRLLDHLQN 326
            ::::|||||:.|.:....||..... .|:.:......:|....:..:..:|||:||.|:...||.
  Fly   192 LVLAPTRELAQQIYRECAELTRETGLRTHFISKVSEAKQKHGAECKQRYDILVSTPNRVRFLLQQ 256

  Fly   327 SPDFL-YKNLQCLIIDEVDRILEIG---FEEELKQIINLLPKRRQTM-LFSATQTARIEALSKLA 386
            .|..| ..:::..::||.||::|.|   |:|:|..|........:.: .||||.|..:...:...
  Fly   257 EPPLLDLSHVEWFVLDEADRLMEEGQNNFKEQLDDIYAACSNPTKCVAFFSATYTVPVAKWALRH 321

  Fly   387 LKS-EPIYVGVHDNQDTATVDGLEQGYIVCPSE-KRLLVLFTFLKKNRKKKVMVFFSSCMSVKYH 449
            ||: ..|.:||   |::|| :.::|..:...|| .:|:.:...:::..:..|:||..|....|..
  Fly   322 LKNLVRITIGV---QNSAT-ETVQQELLFVGSEGGKLVAIRDLVRQGLQPPVLVFVQSKERAKQL 382

  Fly   450 HELFNYIDLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCTDVAARGLDIPQVDWIVQYDPPDDP 514
            .|...|..:.|..||.::.|.:|......|......:|:||::..||:|...|:.::.||.|...
  Fly   383 FEELLYDGINVDVIHAERSQHQRDNCVKAFREGSIWVLICTELMGRGIDFKGVNLVINYDFPPTT 447

  Fly   515 REYIHRVGRTARGSGTSGHALLLMRPEELGFLR----YLKAAKVPLNEFEFSWQKIADIQLQLEK 575
            ..||||:|||.| :|..|.|:.....|:...||    .:|.:...:.|:....:|:...:   .|
  Fly   448 ISYIHRIGRTGR-AGRPGRAITFFTQEDTSNLRGIALIIKNSGGTVPEYMLQMKKVRKSE---AK 508

  Fly   576 LIAKNYFLNQSAKEAFKSYVRAYDSH---QLKQIFNVNTL---------DLQAVAKSFGFLVPPV 628
            :.||.....:......:...:..:.|   :||::.....:         ||.:..|..|.:   .
  Fly   509 MRAKKPLDREDISTKIRPETKGDEKHKSTKLKKVERTEKILKNRKGYEKDLNSKQKKLGNI---K 570

  Fly   629 VDLKVGAAKRERPEKR 644
            .:||....::...||:
  Fly   571 TELKPAGKRKGNVEKK 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	130/483 (27%)
		DEADc	187..394	CDD:238167	67/213 (31%)
		HELICc	408..537	CDD:238034	38/129 (29%)
		DUF4217	569..627	CDD:290667	10/69 (14%)
CG5589	NP_649009.1	SrmB	87..594	CDD:223587	136/521 (26%)
		P-loop_NTPase	123..329	CDD:304359	66/213 (31%)
		HELICc	349..469	CDD:238034	37/120 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451746
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940