DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and mus301

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_648178.1	Gene:	mus301 / 38905	FlyBaseID:	FBgn0002899	Length:	1051	Species:	Drosophila melanogaster

Alignment Length:	805	Identity:	160/805 - (19%)
Similarity:	277/805 - (34%)	Gaps:	256/805 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SKKHVAKDEDDDL----EEDF---QEAP---LPKKKQQKQPPKKQQIQVANSDSESDDDEQEDEA 106
            :.|......||.|    :..|   |..|   ..|..:...|..|.||.:|       |:|..|:.
  Fly    70 TNKMTQSGSDDGLGLFADTSFPSAQSVPPNSASKPDEASAPTDKHQIDLA-------DEENADKL 127

  Fly   107 DEDSDLDEVAEVDEEDVDSGSEDDDQQEDEDEE---EPVPAKKTKLLPNKSKAQNGKPAKDDEPF 168
            .:..:|::::..:.||:..|::|......::.:   :.:..||.| .|.|..|    |.|||...
  Fly   128 FKKINLNDLSIAEMEDIFHGADDFSDPMVQNTQLFLDAMTFKKPK-TPEKLLA----PLKDDSMS 187

  Fly   169 TVESSL-------------------AALDYRDSDDRSFASLK----------------GAVSEAT 198
            .:..|:                   :.||..:.:.::||..:                |...:..
  Fly   188 FISKSVIEGLVQGTQYVTCEELKNQSLLDPVNWETQAFADFEKNNQDIDKFPSKGEFYGLPDKVK 252

  Fly   199 LRAIKEMGFTEMTEIQSKSLT-PLLKGR-DLVGAAQTGSGKTLA-----------------FLIP 244
            ...::..|...:.|.|.:.|. |.::.| :|:.|..|..||||.                 |::|
  Fly   253 KMILEHKGINSLYEWQDECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRERNVLFILP 317

  Fly   245 AVELINK-----------LRFMPRN---GTGVIIISPTRE------LSMQTFGVLKELM--AHHH 287
            .|.::.:           |.|:...   |.|.....|.|:      .|::...||.:.:  ....
  Fly   318 YVSIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFIASIEKGAVLMDSLIDVQRP 382

  Fly   288 HTYGLVMGGSNRQVESEKLGKGINILVATPGRLLDHLQNSPDFLYKNLQCL-------IIDEVDR 345
            |..|||:......: .|| |:|     ||    |:.......||..|:|.:       .:.|:..
  Fly   383 HEIGLVVVDELHLI-GEK-GRG-----AT----LEAFLTKVMFLNANIQIVGMSATIGNLSEISS 436

  Fly   346 ILEI-----GFEE-ELKQIINLLPKRRQTMLFSATQTARIEALSKLALKSEPIYVGVHDNQDTAT 404
            .|..     ||.. |||:.|...|...:  :.||.||     |.::.:.|..:.....:....|.
  Fly   437 FLNADVYTRGFRPVELKEYIKCGPDLLE--INSAGQT-----LEEIFVPSRSVEYNYSEAVKRAD 494

  Fly   405 VDGLEQGYI-----------VCPSEK----------RLLVLFTFLKKNRKKKVMVFFS---SC-- 443
            .|.| .|.|           .|||.|          |::....|.:..|.:|:.:..:   .|
  Fly   495 PDHL-AGLISECAPEHCCLVFCPSRKNCENVALLLSRIVPKHKFFEHRRSEKLDLMDALDKMCGI 558

  Fly   444 ----------MSVKYHHELFNYIDLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCTDVAARGLD 498
                      ..:.|||.       .:|:     .:.|...|.::|  ....::.||...|.|::
  Fly   559 LSPVLAKTLPYGIAYHHS-------GLTT-----DERKYIETAYRF--GVVTVICCTSTLAAGVN 609

  Fly   499 IPQVDWIVQYDPPDDPREYI------HRVGRTAR-GSGTSGHALLLMRP---------------- 540
            :|....|::  .|...:|::      ..|||..| |.|.:|.::|:.:.
  Fly   610 LPAKRVIIR--APYVGQEFLTLCKYKQMVGRAGRAGLGEAGESILIAQSKDNLLVGQMLFSPMDK 672

  Fly   541 --------EELGFLRYLKAAKVPLNEFEFSWQKIADIQLQLEKL--------------IAKNYFL 583
                    |.:| |:.|..:.|.||        :|:.:..|.:|              :|.|..:
  Fly   673 ALSSLDQNEAVG-LQSLILSVVGLN--------LAECRRDLNRLVNSTLLSVQAKSLEVAVNEIV 728

  Fly   584 NQSAKEAFKSYVRAYDSHQLKQIFNVNTLDLQAVAKSFGFLVPPVVDLKVGAAKRERPEKRVGGG 648
            .:..:|.||:.|......|.|.  .:|:.|:             :....|..|.|...::|:..|
  Fly   729 LRILREMFKNKVLQLAEPQAKS--KINSSDI-------------ITSQDVSQANRPAGDRRLLIG 778

  Fly   649 GFGFYKKMNEGSASKQR--HFKQVN 671
            ....:|..|.|.|:.:.  .:|:.|
  Fly   779 QSTPFKLTNIGRAAFKAGIDYKRAN 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	126/639 (20%)
		DEADc	187..394	CDD:238167	58/276 (21%)
		HELICc	408..537	CDD:238034	34/171 (20%)
		DUF4217	569..627	CDD:290667	12/71 (17%)
mus301	NP_648178.1	BRR2	247..998	CDD:224125	123/616 (20%)
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	44/212 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100