DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and CG10333

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_609888.2	Gene:	CG10333 / 35112	FlyBaseID:	FBgn0032690	Length:	822	Species:	Drosophila melanogaster

Alignment Length:	657	Identity:	164/657 - (24%)
Similarity:	285/657 - (43%)	Gaps:	174/657 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 REKM--KKELSQKKGNKNAQKQEPPKQNGNKPSKKPEKLSKKHVAKDEDDDLE-----EDFQEAP 72
            ||:|  ..::|...|...|....||....  |..||:: .::...:|..|.::     :|.:...
  Fly   179 REQMAAASKVSISMGTAMASGAPPPAIVA--PPPKPDR-RERGGGRDRGDRIDRGERGDDKRAED 240

  Fly    73 LPKKKQQKQ-----------PPKKQQIQVANSDSESDDDEQ---EDEADEDSDLD---------- 113
            |..|.::|:           ..||::::..|       |.:   :.:|.||:.:|
  Fly   241 LTHKDKEKELEAIRERYLGIIKKKRRVRRLN-------DRKFVFDWDAGEDTSIDYNNLYKERHH 298

  Fly   114 -------EVAEVD-EEDVDSGSE------DDDQQEDEDEEEPVPAKKTKLLPNKSKAQNGKPAKD 164
                   .||.:| :|...:.|:      :..:.|.|.|:|.|..||.|...:|.|       .|
  Fly   299 VQFFGRGNVAGIDIKEQKRTQSKFYGDLLEKRRTEAEKEQEKVRLKKMKRKEDKQK-------WD 356

  Fly   165 DEPFTVESS--LAALDYRDSDDRSFASLKGAVSEATLRA-------------IKEMGFTEMTEIQ 214
            |..::.:.:  :...|:|...:....::||......:|:             |.::|:.|.|.||
  Fly   357 DRHWSEKENDEMTERDWRIFREDYNVTIKGGRIPNPIRSWNESGFPKEIIDIIDKVGYKEPTPIQ 421

  Fly   215 SKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELINKLRFMPR-----NGTGVIIISPTRELSMQ 274
            .:::...|:.||::|.|:||||||||||||.:..|..|..:.|     .|...||::|||||:.|
  Fly   422 RQAIPIGLQNRDIIGVAETGSGKTLAFLIPLLSWIQSLPKIERLEDVDQGPYAIIMAPTRELAQQ 486

  Fly   275 TFGVLKELMAHHHHTYGL----VMGGSNRQVESEKLGKGINILVATPGRLLDHLQNSPDFLYKNL 335
                ::|.........|:    |:||.:|:.:..:|..|..|::||||||:|.|:|.  :|..|
  Fly   487 ----IEEETTKFGQPLGIRTVVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLENR--YLVLN- 544

  Fly   336 QC--LIIDEVDRILEIGFEEELKQIINLLP-------------------------KRRQTMLFSA 373
            ||  :::||.||::::|||.::::|:..:|                         |.|||::|:|
  Fly   545 QCTYIVLDEADRMIDMGFEPDVQKILEYMPVTNLKPDTEEAEDETKLMENFYTKKKYRQTVMFTA 609

  Fly   374 TQTARIEALSKLAL-KSEPIYVGVHDNQDTATVDGLEQGYIVCPSEKRLLVLFTFLKKNRKKKVM 437
            |....:|.|::..| :...:|:                |.:..|:|:...:::...:.:::||:|
  Fly   610 TMPPAVERLARTYLRRPATVYI----------------GSVGKPTERTEQIVYMMGENDKRKKLM 658

  Fly   438 VFFSSCMSVKYHHELFNYIDLPV------------------------TSIHGKQKQTKRTTTFFQ 478
            ...|            ..||.||                        .::||.:.|.:|......
  Fly   659 EILS------------RKIDPPVIIFVNQKKGADVLAKGLEKLGYNSCTLHGGKGQEQREYALAA 711

  Fly   479 FCNAESGILLCTDVAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEEL 543
            ..:....||:.||||.||:||..|..::.||......:|.||:|||.| :|.:|.|:..:..::.
  Fly   712 LKSGAKDILVATDVAGRGIDIKDVSLVINYDMAKTIEDYTHRIGRTGR-AGKTGCAISFVTKDDS 775

  Fly   544 GFLRYLK 550
            .....||
  Fly   776 ALFYDLK 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	120/439 (27%)
		DEADc	187..394	CDD:238167	79/256 (31%)
		HELICc	408..537	CDD:238034	38/152 (25%)
		DUF4217	569..627	CDD:290667
CG10333	NP_609888.2	DEADc	396..629	CDD:238167	76/239 (32%)
		DEXDc	409..632	CDD:214692	77/245 (31%)
		Helicase_C	651..761	CDD:278689	32/122 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451798
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840