DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and CG8611

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	862	Identity:	229/862 - (26%)
Similarity:	372/862 - (43%)	Gaps:	246/862 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KIVKREKM-KKELSQKKGNKNAQKQEPPKQNGNKPSKKPEKLSKKHVAKDEDDDLEEDFQEAPLP 74
            ||.:.|:: ||:...|...|.:::|.......||..|.|.:|           ....|...|.|.
  Fly   139 KITRAERLGKKQRQGKPLTKLSEEQITRALKSNKKPKNPNQL-----------PTPGDLFRAQLE 192

  Fly    75 KKKQQKQPPKKQQIQVANSDSESDDDEQE------------------DEADEDSDLDEVAEVDEE 121
            ::::||:.      :....|.|:..||::                  .|:.:.||:::..|..||
  Fly   193 EERRQKRR------EEGGGDQEASADEEDAKNNSGGGSPRVKPSSAVKESKKSSDIEDSGESGEE 251

  Fly   122 DVDSGSEDDDQQEDEDEEEPVPAKKTKLLPNKSKAQNGKPAKDDEPFTVE----SSLAALDYRDS 182
            ...|..|.|:.......:|..|.:..|           ||.|.:|..:..    ..:...|..|.
  Fly   252 SATSDEEPDESSAQSPGQEKEPKQTAK-----------KPPKAEETSSTNRFRTKKIGLFDQSDV 305

  Fly   183 DDRSFASLKGAVSEATLRAIKEMGFT------------------------EMTEIQSKSLTPLLK 223
            :     :|| .:.:..::.:||..||                        |:|.:|.|::..:|:
  Fly   306 E-----ALK-QLGQRAVKPVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQ 364

  Fly   224 GRDLVGAAQTGSGKTLAFLIPAVELINKL--RFMPRNGTGVIIISPTRELSMQTFGVLKELMAHH 286
            |:|::..:|||||||||:.:|.|||:.|.  |...::|...::|.|||||.|||:.::::|:  .
  Fly   365 GKDVLVRSQTGSGKTLAYALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLV--K 427

  Fly   287 HHTY---GLVMGGSNRQVESEKLGKGINILVATPGRLLDHLQNSPDFLYKNLQCLIIDEVDRILE 348
            .:|:   |.::||.:|:.|..:|.||||||:.|||||:|||.::..|....||.||:||.||:||
  Fly   428 PYTWIVPGSLLGGESRKSEKARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLE 492

  Fly   349 IGFEEELKQIINLLPKRR-----------QTMLFSATQTARIEALSKLALKSEPIYVGVHDNQDT 402
            :|:|.::||::..:.|:|           |.||.|||.|::::.|:.|.||: |:|:   ||.|.
  Fly   493 LGYERDVKQLVEAIDKQRAECEDKELPQLQRMLLSATLTSQVQQLAGLTLKN-PLYI---DNSDE 553

  Fly   403 A------TVDG--------------------------------LEQGYIVCPSEKRLLVLFTFLK 429
            |      :.||                                |:..|:|.|.:.||:.|.:.|.
  Fly   554 AASAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLA 618

  Fly   430 KN-----RKKKVMVFFSSCMSVKYHHELFNYI---------------------DLPVT------S 462
            |.     ::.|.:||.|:...|.:||::.|..                     |:|:.      .
  Fly   619 KEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFK 683

  Fly   463 IHGKQKQTKRTTTFFQFCNAESGILLCTDVAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARG 527
            :||...||:|...|..|.:..|.:||.|||..||:|:|.:..:|||.||....:::||||||||
  Fly   684 LHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTAR- 747

  Fly   528 SGTSGHALLLMRPEELGFLRYLKAAKVPL----------------NEFEFSWQKIADIQLQLEKL 576
            :|..|.|:|.:.|.|..|:|:|:..::.:                :|.....:..:::|.:.:.|
  Fly   748 AGRKGRAVLFLTPSEAQFVRHLEKKRIRIQQGDMYAYLQTLLPKDDEARTVQEAASNLQHKFQTL 812

  Fly   577 IAKNYFLNQSAKEAFKSYVRAYDS--HQLKQIFNVNTLDLQAVAKSFGF---------------L 624
            :..:..|:..:.:||.|:::.|.:  .:||.||||....:...||||..               .
  Fly   813 LEDDRELHDKSCKAFVSWMKFYSTFPKELKPIFNVRIAHMGHFAKSFALKEAPSKFAAKHAAPKA 877

  Fly   625 VPPVVDL----------------------------------KVGAAKRERPEKRVG--GGGFG-- 651
            .||...|                                  .|||.|...|..:.|  |||.|
  Fly   878 APPTNRLTYTERDPEKIQAQKRAKRRFTTTVSGEVRQLQQRDVGAQKPGAPPPKGGFIGGGVGRS 942

  Fly   652 -FYKKMNEGSASKQRHF 667
             |.|.:.:..|.....|
  Fly   943 SFMKSLGKSRALNMSEF 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	189/664 (28%)
		DEADc	187..394	CDD:238167	89/246 (36%)
		HELICc	408..537	CDD:238034	52/160 (33%)
		DUF4217	569..627	CDD:290667	17/74 (23%)
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	19/92 (21%)
		P-loop_NTPase	332..548	CDD:304359	83/218 (38%)
		DEXDc	348..554	CDD:214692	87/211 (41%)
		HELICc	601..757	CDD:238034	51/156 (33%)
		DUF4217	805..866	CDD:290667	17/60 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451630
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950