DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and ddx31

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_021327284.1	Gene:	ddx31 / 325248	ZFINID:	ZDB-GENE-030131-3973	Length:	739	Species:	Danio rerio

Alignment Length:	744	Identity:	218/744 - (29%)
Similarity:	359/744 - (48%)	Gaps:	176/744 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KQNGNKPSKKPEKLSKKHVAKDEDDDLEEDFQEAPLPKKKQ----QKQPPKKQQIQVANSDSESD 98
            |.|....|...:...||.|||.:   ...:.||:.:.|:::    .:|..:||.:|...|.|:..
Zfish    20 KTNQKHLSSSEKWAQKKRVAKRK---AAVEPQESSVSKQRKINQTGQQHAQKQTLQTPRSPSQRS 81

  Fly    99 DDEQEDEADEDSDLDEVAEVDEEDVDSGSEDDDQQEDEDEEEPVPAKKTKLLPNKSKAQNGKPAK 163
            ::...:|:..                       |:|:.:.:.|   .|.|..|.|:..::....:
Zfish    82 NNRDTEESPV-----------------------QRENSEAKSP---SKVKTFPKKAPTEHEDHGR 120

  Fly   164 DDEPFTVESSLAALDYRDSDDRSFASLKGAVSEATLRAIKEMGFT-------------------- 208
               ||...|||    :|::.:     :...:|.| :..:||..||
Zfish   121 ---PFIKTSSL----FRNNPE-----IPDVLSPA-VNQVKEKVFTSNTFEELNLHPHLVATLHKV 172

  Fly   209 ----EMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELINKLRFMPRNGTG--VIIISP 267
                .||.:|.:::..|:.|:|.|..:|||||||||:.||.|:.:..::...:...|  .::|.|
Zfish   173 LNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDGPLAVVIVP 237

  Fly   268 TRELSMQTFGVLKELMAHHHHTY---GLVMGGSNRQVESEKLGKGINILVATPGRLLDHLQNSPD 329
            ||||::|:|.:.::|:  ...|:   |::|||..::.|..:|.||||:|::|||||:||::|:..
Zfish   238 TRELALQSFQMFQKLL--RPFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLS 300

  Fly   330 FLYKNLQCLIIDEVDRILEIGFEEELKQIINLLPKR---RQTMLFSATQTARIEALSKLALKSEP 391
            ..:..::.||:||.||||::|||::|..|:|.|...   ||.:|.|||.|..:..|:.:::| :|
Zfish   301 IAFSAVRWLILDEADRILDLGFEKDLTVILNALNTAGPYRQNVLLSATITEGLSRLASISMK-DP 364

  Fly   392 IYVGVHDNQDT-----------------ATVDGLEQGYIVCPSEKRLLVLFTFL----KKNRKKK 435
            :.|.|.:..:.                 |..:.|:|..:|.||:..|:.|..|:    |..:::|
Zfish   365 VSVHVSEGSEETVEACPQAAPQALSDSYAVPERLQQHVVVVPSKLHLVCLAAFILAKCKFEQRQK 429

  Fly   436 VMVFFSSCMSVKYHHELFNYI--DLPVTS------------IHGKQKQTKRTTTFFQFCNAESGI 486
            :::|.|||.:|::...||..:  ::|..:            :||..:|.:||..|.:|...::||
Zfish   430 LVIFISSCEAVEFLLNLFTAVLCEIPSNTSSKSTSCLNFYRLHGNMRQEERTEVFQEFSQCKTGI 494

  Fly   487 LLCTDVAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEELGFLRYLKA 551
            ||||||||||||:|||.|||||:||....||:|||||||| .|..|.:||.:.|.|..|:..|..
Zfish   495 LLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTAR-IGAQGSSLLFLTPSETAFVDVLAN 558

  Fly   552 AKVPLNEFEF-----------------SW--QKIAD------------IQLQLEKLI-AKNYFLN 584
            ..:.|:|.:.                 .|  ::.||            :|...|..: |.|..|
Zfish   559 HNISLSEMKMVDILSTLMKDERFKGRGKWDSKRSADAFEQEVRERATLLQTDFENYVHASNESL- 622

  Fly   585 QSAKEAFKSYVRAYDSH--QLKQIFNVNTLDLQAVAKSFGFLVPPVVDLKVGAAKRERPEKRVGG 647
            |:||.|.:.::|||.::  .||.||::..|.|...|||||.              |:.|:
Zfish   623 QTAKSALQCFLRAYTTYPSSLKHIFHIRMLHLGHAAKSFGL--------------RDAPQ----- 668

  Fly   648 GGFGFYKKMNEGSASKQRHFKQVNRDQAK 676
               |....::...|: .:|.|:. :|:||
Zfish   669 ---GLASSISTNPAN-SKHSKKA-KDKAK 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	187/592 (32%)
		DEADc	187..394	CDD:238167	80/238 (34%)
		HELICc	408..537	CDD:238034	62/146 (42%)
		DUF4217	569..627	CDD:290667	23/60 (38%)
ddx31	XP_021327284.1	SrmB	124..613	CDD:223587	160/502 (32%)
ddx31	XP_021327284.1	DUF4217	607..668	CDD:316476	24/75 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920