DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and Ddx31

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001028466.2	Gene:	Ddx31 / 227674	MGIID:	2682639	Length:	687	Species:	Mus musculus

Alignment Length:	716	Identity:	214/716 - (29%)
Similarity:	349/716 - (48%)	Gaps:	169/716 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MKKELSQKKGNKNAQKQEPPKQNGNKPSKKPEKLSKKHVAKDEDDDLEEDFQEAPLPKKKQQKQP 82
            ||::....|.........|       |:|:..::|.....|..|.:.:..|:.:     ..:..|
Mouse     1 MKRQAEATKRKHQVSSDAP-------PAKRRSEISSVLAKKASDKETQRTFKGS-----THKTFP 53

  Fly    83 PKKQQIQVANSDSESDDDEQEDEADEDSDL----DEVAEVDEEDVDSGSEDDDQQEDEDEEEPVP 143
            |||.      .||..:..::|....:.|.|    .|:.|:....|        :|..|....|..
Mouse    54 PKKY------LDSIGNGRQEEKPCIKTSSLFKNNPEIPELHSTVV--------KQAREQVFSPEA 104

  Fly   144 AKKTKLLPNKSKAQNGKPAKDDEPFTVESSLAALDYRDSDDRSFASLKGAVSEATLRAIKEMGFT 208
            .::..|.|:..                                          :|:..:.:|  :
Mouse   105 FQELDLHPHLI------------------------------------------STINTVLKM--S 125

  Fly   209 EMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELINKL--RFMPRNGTGVIIISPTREL 271
            .||.:|.:|:..||:|||.:..:|||||||||:.:|.|:.:..|  :....:|...:::.|||||
Mouse   126 SMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCVPVVQSLQALTSKIQRSDGPYALVLVPTREL 190

  Fly   272 SMQTFGVLKELMAHHHHTY---GLVMGGSNRQVESEKLGKGINILVATPGRLLDHLQNSPDFLYK 333
            ::|:|..:::|:  ...|:   |::|||..|:.|..:|.||||||::|||||:||::::.:..:.
Mouse   191 ALQSFDTVQKLL--KPFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNLHFN 253

  Fly   334 NLQCLIIDEVDRILEIGFEEELKQIINLLP---KRRQTMLFSATQTARIEALSKLALKSEPIYVG 395
            .::.||:||.||||::|||:::..|:|.:.   ::||.:|.|||.|..:..|..::|.: |:.:.
Mouse   254 RIRWLIVDEADRILDLGFEKDITVILNAVNAECQKRQNVLLSATLTEGVTRLVDISLHN-PVSIS 317

  Fly   396 VHD---NQ----DTATV--------DGLEQGYIVCPSEKRLLVLFTFL----KKNRKKKVMVFFS 441
            |.|   ||    :.|::        :.|:|..::.||:.||:.|..|:    |..:.:|::||||
Mouse   318 VLDKNCNQPNPKEVASIQLNSFAIPESLDQHVVLVPSKLRLVCLAAFILQKCKFEKNQKMIVFFS 382

  Fly   442 SCMSVKYHHELFNYI-----------DLPVTS-------IHGKQKQTKRTTTFFQFCNAESGILL 488
            ||..|::|:.||.:.           .||..|       :||..:|.:||:.|.:|.::|:|:||
Mouse   383 SCELVEFHYSLFLHTLLCHSGTPTSEHLPSASWPLKFLRLHGNMEQEERTSVFHEFSHSETGVLL 447

  Fly   489 CTDVAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEELGFLRYLKAAK 553
            |||||:||||:|||.|||||..|..|.|||||:||||| .|..|.:||::.|.|..::..|.:.|
Mouse   448 CTDVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTAR-IGCHGSSLLILAPSEAEYVNSLASHK 511

  Fly   554 VPLNEFEFSWQKIADIQLQLEK------------------------------LIAKNYFLNQS-- 586
            :.:.|.     |:.||...|.|                              .:.::|..:..
Mouse   512 INVGEI-----KMEDILAVLAKDDCFKRRQRGAQKSRASGPQEIRERATVLQTVFEDYVHSSQRM 571

  Fly   587 ---AKEAFKSYVRAYDSH--QLKQIFNVNTLDLQAVAKSFGFLVPPVVDLKVGAAKR---ERPEK 643
               ||:|.:|::|||.::  :||.||:|..|.|..||||||....| .:|.|.|.|:   :||..
Mouse   572 VSWAKKALQSFIRAYATYPKELKSIFHVRALHLGHVAKSFGLRDAP-RNLSVSAVKKASLKRPHP 635

  Fly   644 R 644
            |
Mouse   636 R 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	187/544 (34%)
		DEADc	187..394	CDD:238167	76/214 (36%)
		HELICc	408..537	CDD:238034	66/150 (44%)
		DUF4217	569..627	CDD:290667	24/94 (26%)
Ddx31	NP_001028466.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		16/79 (20%)
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	103..132		6/72 (8%)
		PRK04837	105..553	CDD:235314	160/500 (32%)
		P-loop_NTPase	105..317	CDD:304359	78/258 (30%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	261..264		2/2 (100%)
		HELICc	347..495	CDD:238034	65/148 (44%)
		DUF4217	557..618	CDD:290667	22/61 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..687		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920