DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and F55F8.2

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_491652.1	Gene:	F55F8.2 / 172223	WormBaseID:	WBGene00018890	Length:	746	Species:	Caenorhabditis elegans

Alignment Length:	739	Identity:	193/739 - (26%)
Similarity:	325/739 - (43%)	Gaps:	156/739 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ELSQKKGNKNAQKQEPPKQNGNKPSKKPEKLSKKHVAKDEDDDLEEDFQEAPLPKKKQQKQPPKK 85
            |:..|||.|   |:..||:..|  :::||          ||....|:.:.|...::|:|....:|
Worm    42 EVETKKGMK---KKNKPKKVEN--TERPE----------EDAKCVEERRLAKKLRRKEQMAANRK 91

  Fly    86 QQIQVANSDSESDDDEQEDEADEDSDLDEVAEVDEEDVDSGSEDDDQQEDEDEEEPVPAKKTKLL 150
            |:                        .:.:|:..:::.:|.::..:...:...|:|...||.|
Worm    92 QK------------------------KERLAKRKQKEAESSAKKSENATETTTEKPKEQKKRK-- 130

  Fly   151 PNKSKAQNGKPAKDDEPFTVESSLAALDYRDSDDRSFASLKGAVSEATLRAIKEMGFTEMTEIQS 215
             .......|||.|..:..:.::.::|.       :.|..|...|    |.||::|||:|.|||||
Worm   131 -GGENGDTGKPKKSKKEASKKTDISAW-------KQFYFLPNEV----LEAIEQMGFSEPTEIQS 183

  Fly   216 KSLTPLLKGR-DLVGAAQTGSGKTLAFLIPAVELI-------NKLRFMPRNGTGVIIISPTRELS 272
            ..|...::.| |::|||:|||||||||.||.|..:       .:.......|...:|::|||||.
Worm   184 AVLPAAVRDRQDVLGAAETGSGKTLAFGIPLVARLLESSDDSQETESTEVRGPRALIVAPTRELV 248

  Fly   273 MQTFGVLKELMAHHHHTYGLVMGGSNRQVESEKL--GKGINILVATPGRLLDHLQNSP--DFL-- 331
            :|....:..|::........::||. .||:.|::  .:..:|:|||||||...:|.:.  :||
Worm   249 IQIMKHINALISTTQLIATSIVGGL-AQVKQERIISQQRPDIVVATPGRLWAMMQEAETGEFLAE 312

  Fly   332 YKNLQCLIIDEVDRILEIGFEEELKQIINLL-----PKRRQTMLFSATQT--------------- 376
            :|:|:||::||.||::|.|:..||..|:|.:     .::.||::||||.|
Worm   313 WKDLKCLVVDETDRMVEEGYFAELTHILNKIHEESEKEKLQTLVFSATLTFAKAQDVAEEEKKKA 377

  Fly   377 ------ARIEALSKLALKSEPIYVGVHDNQDTATVDGLEQGYIVCPSEKRL-----------LVL 424
                  .:|:.|.||        .|:.:|:........:.|...|..|.|:           ||
Worm   378 KELSSQQKIQRLIKL--------TGLRENKHKVIDLTRQMGTAGCLVEARINCGNLLEKDTSLV- 433

  Fly   425 FTFLKKNRKKKVMVFFSSCMSVKYHHELFNYIDLPVTSIHGKQKQTKRTTTFFQFCNAESGILLC 489
              :|......:.:||.:|..:.:..:.:...:::....:|.|..|.:|.....:|..:::.:||.
Worm   434 --YLLTRYPGRTIVFVNSIDAARRLYSVLKSVNIDPMILHAKMIQKQRLKNLEKFSESKNAVLLA 496

  Fly   490 TDVAARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEELGFLRYLKAAK- 553
            ||||||||||..:|.::.|..|.....||||.|||||.| ..|..::|:.|....|  |:|..|
Worm   497 TDVAARGLDIQGIDHVIHYQVPKKVEIYIHRSGRTARAS-HRGLTVVLVDPPSRQF--YMKLCKG 558

  Fly   554 ----VPLNEFEFSWQKIADIQLQLEKLIAKNYFLNQSAKEA------FKSYVRA----YDSHQLK 604
                ..||.|...::.:.:...:..:|.::...|....|:.      |:...||    ||..:.:
Worm   559 LNRMQDLNVFPIDFEPLMNAIKKRVRLASEIDSLGFRCKKIKMSESWFEKAARAADLDYDETRHR 623

  Fly   605 QIFNVN---------TLDLQAVAKSFGFLVPPVVDLKVGA----AKRERPE-----KRVGGGGFG 651
            ::..:|         :..|||..::...|..|.||   |:    .|...||     :.||.....
Worm   624 EMDGLNLEVDTMVQKSRQLQAQLRTELSLPLPRVD---GSDSMKTKYITPEIVARLRSVGDNAID 685

  Fly   652 -FYKKMNEGSASKQRHFKQVNRDQ 674
             ..:|::|....|::..|....|:
Worm   686 VLNQKIDETKEWKRKSRKATREDE 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	162/574 (28%)
		DEADc	187..394	CDD:238167	83/246 (34%)
		HELICc	408..537	CDD:238034	41/139 (29%)
		DUF4217	569..627	CDD:290667	13/76 (17%)
F55F8.2	NP_491652.1	DUF3381	<40..106	CDD:288694	20/102 (20%)
		SrmB	160..618	CDD:223587	140/476 (29%)
		P-loop_NTPase	162..362	CDD:304359	77/204 (38%)
		Helicase_C	427..534	CDD:278689	34/109 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920