DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pit and ddx51

DIOPT Version :9

Sequence 1:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_002931939.2	Gene:	ddx51 / 100135117	XenbaseID:	XB-GENE-5837731	Length:	659	Species:	Xenopus tropicalis

Alignment Length:	737	Identity:	182/737 - (24%)
Similarity:	293/737 - (39%)	Gaps:	194/737 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 REKLLMKKIVKREKMKKELSQKKGNKNAQKQEPPKQNGNKPS-----KKPEKLSKKHVAKDE--- 60
            |.|.|::|:.::.|.:::..|....|.:.|.:..::...|||     :|.:|..||...::|
Frog    20 RSKALLQKLHEQAKDRQQQRQHPKAKASPKDDHVEETNTKPSINETLRKTKKRKKKQEEEEEGEL 84

  Fly    61 ---DDDLEEDF--QEAPLPKKKQQKQPPKKQQIQVANSDSESDDDEQEDEADEDSDLDEVAEVDE 120
               .|:.|:|.  |||...|:|:|.:..||...:..|...|......|....|:....:|...|.
Frog    85 KSPSDENEQDSGQQEATCIKEKKQTKKKKKLIAEECNEVIEHISKNNEGSMAEEPGGAKVTSSDP 149

  Fly   121 EDVDSGSEDDDQQEDEDEEEPVPAKKTKL----LPNKSKAQNGKPAKDDEPFTVESSLAALDYRD 181
            ..:..|.     .|.:..|:.:|.....|    |..|:..||..|..|..
Frog   150 SSILLGG-----FEPKSVEKVLPVLPQWLAQPSLVQKNIKQNLVPIHDIH--------------- 194

  Fly   182 SDDRSFASLKGAVSEATLRAIKEMGFTEMTEIQSKSLTPLL----------KG----RDLVGAAQ 232
                       .:....|:.::......:..:|::.:..:|          ||    .|:..:|.
Frog   195 -----------CLHPKVLKKLEANKVKYLFPVQAEVIPAILDSTCHGFLLGKGGYRPSDVCVSAP 248

  Fly   233 TGSGKTLAFLIPAVE-LINKLRFMPRNGTGVIIISPTRELSMQTFGVLKELMAHHHHTY----GL 292
            |||||||||:||.|: |:.::....|    .:::.||:||:.|...|.        :||    ||
Frog   249 TGSGKTLAFVIPIVQALLQRVVCEVR----ALVVLPTKELAQQVCKVF--------NTYVDGMGL 301

  Fly   293 ----VMGGSNRQVESE----KLGKGI----NILVATPGRLLDHLQNSPDFLYKNLQCLIIDEVDR 345
                |.|..:...|.|    |...|.    :|||.|||||:||:|.:..|..::|:.|:|||.||
Frog   302 KVVMVTGQKSFLKEQESLIHKTAFGFCSLADILVCTPGRLVDHIQQTEGFNLRHLRFLVIDEADR 366

  Fly   346 ILEIGFEEELKQII-----------NLLPKRR-----------------QTMLFSATQTARIEAL 382
            :::...::.|..:.           |:|..|:                 |.:|||||.|...|.|
Frog   367 MIDSMNQDWLSHVTKAVFQVVADSPNMLFTRKEPGILTAASSCLPQTPLQKLLFSATLTQNPEKL 431

  Fly   383 SKLALKSEPIYV----GVHDNQDTATV-----------DGLEQGYIVCPSEKRLLVLFTFLKKNR 432
            .:|.|....::.    |..|:.....:           :||...||.|....:.|:|..||...|
Frog   432 KQLGLYQPRLFTSKQKGTSDDSSETQMESSTSGNFSLPEGLTHYYIPCNLNSKPLILLHFLLSLR 496

  Fly   433 KKKVMVFFSSCMSVKYHHELF----NYIDLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCTDVA 493
            ..:|:.|.:|..:   .|.|:    ::..:.|.....:....:|..|..:|...:..:|:.||..
Frog   497 FSRVLCFTNSRDA---SHRLYLLVRSFGGISVAEFSSRLSPGERKKTLKEFEQGKVQLLISTDAT 558

  Fly   494 ARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHAL-LLMRPEELGFLRYLKAAKVPLN 557
            |||:||..|..::.||.|...|.|:|||||||| :|.:|.|. :|::.:|..:...|:.|..|
Frog   559 ARGIDIKGVKCVINYDAPQFIRTYVHRVGRTAR-AGKAGLAFTMLLKVQENPYFSMLRDAGAP-- 620

  Fly   558 EFEFSWQKIADIQLQLEKLIAKNYFLNQSAKEAFKSYVRAYDSHQLKQIFNVNTLDLQAVAKSFG 622
                      ::|.||.|            .|..|.|.:.|:.         ..::||.
Frog   621 ----------EMQKQLVK------------SENLKQYEQRYEE---------ALIELQR------ 648

  Fly   623 FLVPPVVDLKVGAAKRERPEKR 644
                        |.|.||.:||
Frog   649 ------------AVKNERAQKR 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pit	NP_001287459.1	SrmB	186..677	CDD:223587	138/538 (26%)
		DEADc	187..394	CDD:238167	71/265 (27%)
		HELICc	408..537	CDD:238034	43/133 (32%)
		DUF4217	569..627	CDD:290667	10/57 (18%)
ddx51	XP_002931939.2	DEADc_DDX51	200..443	CDD:350714	71/254 (28%)
ddx51	XP_002931939.2	SF2_C_DEAD	472..602	CDD:350174	43/133 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010