DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6015 and CDC40

DIOPT Version :9

Sequence 1:	NP_651005.1	Gene:	CG6015 / 42593	FlyBaseID:	FBgn0038927	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_010652.3	Gene:	CDC40 / 851968	SGDID:	S000002772	Length:	455	Species:	Saccharomyces cerevisiae

Alignment Length:	425	Identity:	152/425 - (35%)
Similarity:	232/425 - (54%)	Gaps:	28/425 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 KTVFEPPKAKKLRKQEKNDNPEDIEGFLGPWGKFENEVSVAKPNEQERAEL-------DELLSKR 220
            |:.|...:.|:.||..|.|.|      .|.|...::|.|.|...::|..::       |.|.|
Yeast    48 KSHFTKSELKRRRKTRKGDGP------WGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDS-- 104

  Fly   221 HKRGRIPEDKPLEEKSTLHIKDAYDYQGRSYLHAPHDLGVNLRSNAPPTKCFLPKAHIHTWSGHN 285
                   |...:||.|..:.|...|||||.||:.|:|:.|:||......:|:|||..|..:.||.
Yeast   105 -------EQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHP 162

  Fly   286 KGISSIRWFPKTAHLLLSGSMDCRVKLWEVYGERRCIRTFSGHRQAIKDIAWNNRGTNFLSASYD 350
            :|.:::::.|||.||:|||..|..:|:|:.|.:..|:|.|.||.:.||.:.:.....:|||:|:|
Yeast   163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFD 227

  Fly   351 RYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNSKQHLFVAGTSDKKIICWDTRSGD---IVQEYD 412
            |.:|:||.|||.|.:|......|..|:..|.|  .|.|:.|.|:.||:.:|.|..:   :||.||
Yeast   228 RSVKIWDTETGKVKTRLHLNSTPADVESRPTN--PHEFIVGLSNSKILHYDDRVSENQGLVQTYD 290

  Fly   413 RHLGSVSTITFVDDNRRFVTTSDDKSMRIWEWDIPVDMKYIADPTMHSMPAVTLAPNGKWMACQS 477
            .||.|:..:.:..|..:|:::|:||::||||..|.|.:|.|:|...||||.:.:.|:..:...||
Yeast   291 HHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQS 355

  Fly   478 LDNKIVIFSALNRFKMNRKKTFTGHMVSGYACQLDFSPDMSYLVSGDGDGKCYIWDWKTTKMYKK 542
            :||:|..||...::|.:.||.|.||..:||...|.||.|..|:.|||...:.:.|||.|:::...
Yeast   356 MDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN 420

  Fly   543 WQAHDGVCISAL-WHPHEASKVVTAGWDGQIKYWD 576
            .:......|:.: |||.|.|||:.:|..|:|...|
Yeast   421 IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6015	NP_651005.1	WD40	<274..576	CDD:225201	115/305 (38%)
		WD40	277..576	CDD:238121	113/302 (37%)
		WD40 repeat	289..327	CDD:293791	15/37 (41%)
		WD40 repeat	332..368	CDD:293791	16/35 (46%)
		WD40 repeat	374..412	CDD:293791	13/40 (33%)
		WD40 repeat	418..453	CDD:293791	12/34 (35%)
		WD40 repeat	461..500	CDD:293791	13/38 (34%)
		WD40 repeat	509..532	CDD:293791	8/22 (36%)
CDC40	NP_010652.3	WD40	154..408	CDD:238121	98/255 (38%)
		WD40 repeat	166..204	CDD:293791	15/37 (41%)
		WD40 repeat	210..247	CDD:293791	15/36 (42%)
		WD40 repeat	252..290	CDD:293791	13/39 (33%)
		WD40 repeat	297..332	CDD:293791	12/34 (35%)
		WD40 repeat	339..378	CDD:293791	13/38 (34%)
		WD40 repeat	386..422	CDD:293791	12/35 (34%)
		WD40 repeat	429..453	CDD:293791	11/23 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346648
Domainoid	1	1.000	40	1.000	Domainoid score	I3258
eggNOG	1	0.900	-	-		E1_KOG0282
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55903
OrthoFinder	1	1.000	-	-		FOG0004340
OrthoInspector	1	1.000	-	-		oto99358
orthoMCL	1	0.900	-	-		OOG6_102256
Panther	1	1.100	-	-	LDO	PTHR43979
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R987
SonicParanoid	1	1.000	-	-		X3608
TreeFam	1	0.960	-	-
	14	13.790