DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6015 and WDR25

DIOPT Version :9

Sequence 1:NP_651005.1 Gene:CG6015 / 42593 FlyBaseID:FBgn0038927 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_001154948.1 Gene:WDR25 / 79446 HGNCID:21064 Length:544 Species:Homo sapiens


Alignment Length:556 Identity:129/556 - (23%)
Similarity:217/556 - (39%) Gaps:129/556 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 EKAHINAFEFENQRRTFHTYGYALDPSVDDQADGQSFVGDLQSAYDDNGKTVFEPPKAKKLRKQE 178
            |..|..:|....|::  .|.|.|..|       ||.|...           ..:.|||.  .:..
Human    23 ETEHAGSFNATGQQK--DTSGVARPP-------GQDFASG-----------TLDVPKAG--AQPT 65

  Fly   179 KNDNPEDIEGFLGP--------WGKFEN--------EVSVAKPNEQER----------AELDELL 217
            |:.:.||..|:..|        ||...:        |..|..|.::..          |....|.
Human    66 KHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTSHVPASHMPLA 130

  Fly   218 SKRHKRGRIPEDKPLEEKSTLHIKDAYDYQGRS-------------YLHAPHDL----------- 258
            :.|.|:.::..:.|   ||:.|.:...:..|::             ..:.|..|           
Human   131 AARFKQVKLSRNFP---KSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRRLRQRQALSTETG 192

  Fly   259 -GVNLRSNAPPT--------------------------KCFLPKAHIHTWSGHNKGISSIRWFP- 295
             |.::....||.                          :..:|:..:....||...:::|:|.| 
Human   193 KGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLFHLRGHRGPVNTIQWCPV 257

  Fly   296 -KTAHLLLSGSMDCRVKLWEVYGERRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWDAE 359
             ..:|:|||.|||...|:|.......|::|:|.|.:|::...|...|...||..:|..:.|.|.|
Human   258 LSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLE 322

  Fly   360 TGDVV------SRFTTRKMPFCVKFHPDNSKQH-LFVAGTSDKKIICWDTRSGDIVQEYDRHLGS 417
            ||..:      .|.||      :||||   |.| :|:.|....::..||.|:|.:::.|...:..
Human   323 TGTQLFSGRSDFRITT------LKFHP---KDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQ 378

  Fly   418 VSTITFVDDNRRFVTTSD----DKSMR-IWEWDIPVDMKYIADPTMH---SMPAVTLAPNGKWMA 474
            ...|.|:.:...|::::|    |.:.| |..||.....| |::...|   :.|::.|.|......
Human   379 TLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAK-ISNQIFHERFTCPSLALHPREPVFL 442

  Fly   475 CQSLDNKIVIFSALNRFKMNRKKTFTGHMVSGYACQLDFSPDMSYLVSGDGDGKCYIWDWKTTKM 539
            .|:..|.:.:||.:..::|:|::.:.||.|.||:...:.||....||:|..||:..::.::|...
Human   443 AQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASR 507

  Fly   540 YKKWQAHDGVCISALWHPHEASKVVTAGWDGQIKYW 575
            ....|.|...|:...:||...|.:.|..|.|.:|.|
Human   508 ACTLQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6015NP_651005.1 WD40 <274..576 CDD:225201 91/319 (29%)
WD40 277..576 CDD:238121 90/316 (28%)
WD40 repeat 289..327 CDD:293791 14/39 (36%)
WD40 repeat 332..368 CDD:293791 11/41 (27%)
WD40 repeat 374..412 CDD:293791 12/38 (32%)
WD40 repeat 418..453 CDD:293791 10/39 (26%)
WD40 repeat 461..500 CDD:293791 9/38 (24%)
WD40 repeat 509..532 CDD:293791 7/22 (32%)
WDR25NP_001154948.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 17..74 17/72 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..208 3/24 (13%)
WD40 239..543 CDD:330360 89/313 (28%)
WD 1 244..286 15/41 (37%)
WD40 repeat 251..290 CDD:293791 14/38 (37%)
WD 2 290..329 12/38 (32%)
WD40 repeat 296..330 CDD:293791 10/33 (30%)
WD 3 330..373 15/51 (29%)
WD40 repeat 336..373 CDD:293791 14/45 (31%)
WD 4 375..420 11/45 (24%)
WD40 repeat 380..422 CDD:293791 11/42 (26%)
WD 5 424..463 9/38 (24%)
WD40 repeat 429..468 CDD:293791 9/38 (24%)
WD 6 469..510 13/40 (33%)
WD40 repeat 476..512 CDD:293791 8/35 (23%)
WD 7 513..544 10/31 (32%)
WD40 repeat 518..543 CDD:293791 8/24 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0282
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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