DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6015 and Cdc40

DIOPT Version :9

Sequence 1:	NP_651005.1	Gene:	CG6015 / 42593	FlyBaseID:	FBgn0038927	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_082155.1	Gene:	Cdc40 / 71713	MGIID:	1918963	Length:	579	Species:	Mus musculus

Alignment Length:	577	Identity:	356/577 - (61%)
Similarity:	447/577 - (77%)	Gaps:	14/577 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SYASSSDEESDHADAATATTNSEPS-APIP--DHLLPVDKTHS--LSKSIAVCAAPTVVPLGASA 65
            ||.|.|..|||        ::||.| .|:|  |.|:.:.|:.|  ||.::||.:||.|.......
Mouse    11 SYGSGSGSESD--------SDSEGSRCPLPAADSLMHLTKSPSAKLSLTVAVDSAPEVAVKEDLE 67

  Fly    66 VPRTLDPTLKEVTYNPRYEEMYAPVKGPEHPDLTMQQRAPRNTLAGYVEKAHINAFEFENQRRTF 130
            ....|||.:|||.|||.||.|:||..|||:|..|.|..||||.|:||.|.||||.|.||.|||||
Mouse    68 TGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTF 132

  Fly   131 HTYGYALDPSVDDQADGQSFVGDLQSAYDDNGKTVFEPPKAK-KLRKQEKNDNPEDIEGFLGPWG 194
            .|||||||||:|:......::|.::.|..:.|.||||..:.| :.||:.|.::..:|:||||||.
Mouse   133 ATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWA 197

  Fly   195 KFENEVSVAKPNEQERAELDELLSKRHKRGRIPEDKPLEEKSTLHIKDAYDYQGRSYLHAPHDLG 259
            |:.:|..||||:|:|:.||||:.:||.|:|:..|:||.|||:.||:|:.||||||||||.|.|:|
Mouse   198 KYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVG 262

  Fly   260 VNLRSNAPPTKCFLPKAHIHTWSGHNKGISSIRWFPKTAHLLLSGSMDCRVKLWEVYGERRCIRT 324
            |||||:.||.||:|||..||.||||.||:|::|.||.:.|||||.||||::|||||||:|||:||
Mouse   263 VNLRSSVPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGDRRCLRT 327

  Fly   325 FSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNSKQHLFV 389
            |.||.:|::||.:|..||.||||:||||:||||.|||..:||||.||:|:||||:||..||:|||
Mouse   328 FIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFV 392

  Fly   390 AGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTSDDKSMRIWEWDIPVDMKYIA 454
            ||.|||||:.||.|||:||||||||||:|:||.|||:|||||:||||||:|:||||||||.||||
Mouse   393 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 457

  Fly   455 DPTMHSMPAVTLAPNGKWMACQSLDNKIVIFSALNRFKMNRKKTFTGHMVSGYACQLDFSPDMSY 519
            :|:|||||||||:|||||:||||:||:|:||.|.|||::|:||.|.||||:|||||:||||||||
Mouse   458 EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSY 522

  Fly   520 LVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPHEASKVVTAGWDGQIKYWD 576
            ::||||:||..||||||||:|.:::|||.|||.|:|||||.|||:|.||||.||.||
Mouse   523 VISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6015	NP_651005.1	WD40	<274..576	CDD:225201	215/301 (71%)
		WD40	277..576	CDD:238121	213/298 (71%)
		WD40 repeat	289..327	CDD:293791	26/37 (70%)
		WD40 repeat	332..368	CDD:293791	22/35 (63%)
		WD40 repeat	374..412	CDD:293791	27/37 (73%)
		WD40 repeat	418..453	CDD:293791	27/34 (79%)
		WD40 repeat	461..500	CDD:293791	27/38 (71%)
		WD40 repeat	509..532	CDD:293791	16/22 (73%)
Cdc40	NP_082155.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		12/30 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..237		17/32 (53%)
		WD40	281..579	CDD:238121	213/297 (72%)
		WD 1	286..326		27/39 (69%)
		WD40 repeat	292..330	CDD:293791	26/37 (70%)
		WD 2	330..369		23/38 (61%)
		WD40 repeat	335..371	CDD:293791	22/35 (63%)
		WD 3	371..413		29/41 (71%)
		WD40 repeat	377..415	CDD:293791	27/37 (73%)
		WD 4	416..455		30/38 (79%)
		WD40 repeat	421..503	CDD:293791	61/81 (75%)
		WD 5	459..498		28/38 (74%)
		WD 6	504..545		32/40 (80%)
		WD40 repeat	511..547	CDD:293791	26/35 (74%)
		WD 7	548..578		22/29 (76%)
		WD40 repeat	553..578	CDD:293791	18/24 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850400
Domainoid	1	1.000	264	1.000	Domainoid score	I1913
eggNOG	1	0.900	-	-		E1_KOG0282
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5716
Inparanoid	1	1.050	758	1.000	Inparanoid score	I551
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55903
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004340
OrthoInspector	1	1.000	-	-		oto92919
orthoMCL	1	0.900	-	-		OOG6_102256
Panther	1	1.100	-	-	LDO	PTHR43979
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R987
SonicParanoid	1	1.000	-	-		X3608
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790