DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6015 and cdc40

DIOPT Version :9

Sequence 1:	NP_651005.1	Gene:	CG6015 / 42593	FlyBaseID:	FBgn0038927	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001011457.1	Gene:	cdc40 / 496947	XenbaseID:	XB-GENE-954563	Length:	567	Species:	Xenopus tropicalis

Alignment Length:	577	Identity:	350/577 - (60%)
Similarity:	432/577 - (74%)	Gaps:	14/577 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGLQSYASSSDEESDHADAATATTNSEPSAPIPDHLLPVDKTHSLSKSIAVCAAPTVVPLGASA 65
            :..|.||.|:||.:|: ||:...:.:.:...|....|..||            :||.|.......
Frog     4 LTSLVSYGSASDSDSE-ADSEDCSAHLKSLPPGTGVLRVVD------------SAPEVAVKEDVE 55

  Fly    66 VPRTLDPTLKEVTYNPRYEEMYAPVKGPEHPDLTMQQRAPRNTLAGYVEKAHINAFEFENQRRTF 130
            ....|||..|||.:||.||.|:||..||::|..|.|..||||.|:||.|..|||.|.||.|||||
Frog    56 TGDHLDPYAKEVQFNPTYETMFAPEFGPKNPFKTQQMAAPRNMLSGYAEPTHINDFMFEQQRRTF 120

  Fly   131 HTYGYALDPSVDDQADGQSFVGDLQSAYDDNGKTVFEPPKAKK-LRKQEKNDNPEDIEGFLGPWG 194
            .|||||||||:|.|.....::|.:..|..:.|.||||..:.|. .||:.|..:..:|:||||||.
Frog   121 ATYGYALDPSIDHQETSTKYIGSVDEAEKNQGLTVFETTQKKSDKRKKVKGSDASNIDGFLGPWA 185

  Fly   195 KFENEVSVAKPNEQERAELDELLSKRHKRGRIPEDKPLEEKSTLHIKDAYDYQGRSYLHAPHDLG 259
            |:.:|..||||:|:|:.||||:.:||.|||:..||||.|||:.||:|:.||||||||||.|.|:.
Frog   186 KYIDEKDVAKPSEEEQKELDEITAKRQKRGKQEEDKPAEEKTILHVKEMYDYQGRSYLHIPQDID 250

  Fly   260 VNLRSNAPPTKCFLPKAHIHTWSGHNKGISSIRWFPKTAHLLLSGSMDCRVKLWEVYGERRCIRT 324
            |||||...|.||:|||..||.||||.||:|::|.||.:.|||||.||||::||||||.:|||:||
Frog   251 VNLRSTEFPEKCYLPKKQIHVWSGHTKGVSAVRLFPVSGHLLLSCSMDCKIKLWEVYKDRRCLRT 315

  Fly   325 FSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNSKQHLFV 389
            |.||.:|::||::||.||.||||:||||:||||.|||..:||||.||:|:||||:||..||.|||
Frog   316 FIGHSKAVRDISFNNAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQSLFV 380

  Fly   390 AGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTSDDKSMRIWEWDIPVDMKYIA 454
            ||.|||||:.||.|||:||||||||||:|:||||||:|||||:||||||:|:||||||||.||||
Frog   381 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTITFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 445

  Fly   455 DPTMHSMPAVTLAPNGKWMACQSLDNKIVIFSALNRFKMNRKKTFTGHMVSGYACQLDFSPDMSY 519
            :|:|||||||||:|||||:||||:||:|:||.|.|||::|:||.|.||||:|||||:||||||||
Frog   446 EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSY 510

  Fly   520 LVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPHEASKVVTAGWDGQIKYWD 576
            :||||.|||..||||||||:|.:.:|||.|||||:|||||.|||:|.||||.||.||
Frog   511 VVSGDADGKLNIWDWKTTKLYSRLKAHDKVCISAVWHPHETSKVITCGWDGLIKLWD 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6015	NP_651005.1	WD40	<274..576	CDD:225201	218/301 (72%)
		WD40	277..576	CDD:238121	216/298 (72%)
		WD40 repeat	289..327	CDD:293791	25/37 (68%)
		WD40 repeat	332..368	CDD:293791	23/35 (66%)
		WD40 repeat	374..412	CDD:293791	27/37 (73%)
		WD40 repeat	418..453	CDD:293791	28/34 (82%)
		WD40 repeat	461..500	CDD:293791	27/38 (71%)
		WD40 repeat	509..532	CDD:293791	17/22 (77%)
cdc40	NP_001011457.1	WD40	269..567	CDD:238121	216/297 (73%)
		WD40 repeat	280..318	CDD:293791	25/37 (68%)
		WD40 repeat	323..359	CDD:293791	23/35 (66%)
		WD40 repeat	365..403	CDD:293791	27/37 (73%)
		WD40 repeat	409..491	CDD:293791	62/81 (77%)
		WD40 repeat	499..535	CDD:293791	27/35 (77%)
		WD40 repeat	541..566	CDD:293791	19/24 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	246	1.000	Domainoid score	I2125
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5716
Inparanoid	1	1.050	742	1.000	Inparanoid score	I587
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004340
OrthoInspector	1	1.000	-	-		oto103182
Panther	1	1.100	-	-	LDO	PTHR43979
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3608
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.150