DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6015 and cdc40

DIOPT Version :9

Sequence 1:	NP_651005.1	Gene:	CG6015 / 42593	FlyBaseID:	FBgn0038927	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001009990.1	Gene:	cdc40 / 494534	ZFINID:	ZDB-GENE-050116-3	Length:	578	Species:	Danio rerio

Alignment Length:	580	Identity:	357/580 - (61%)
Similarity:	444/580 - (76%)	Gaps:	16/580 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQSYASSSDEESDHADAATATTNSEPSAPIPDHLLPVDKTHSLSKSIAVCAAPTV-----VPLGA 63
            |.||.|.||.|:: :::.......:|.|.:  ||.|: |:..::....:.:||.|     |..|.
Zfish     8 LVSYGSDSDSENE-SESPNNPQEIDPDALV--HLKPL-KSGGVTTVAVLNSAPEVAVKEDVETGV 68

  Fly    64 SAVPRTLDPTLKEVTYNPRYEEMYAPVKGPEHPDLTMQQRAPRNTLAGYVEKAHINAFEFENQRR 128
            .     |||.||||:|||.||.|:||..||.:|..:.|..||||.|:||.|.||:|.|.||.|||
Zfish    69 H-----LDPALKEVSYNPTYETMFAPEFGPMNPFRSQQMAAPRNMLSGYAEPAHVNDFMFEQQRR 128

  Fly   129 TFHTYGYALDPSVD-DQADGQSFVGDLQSAYDDNGKTVFEP-PKAKKLRKQEKNDNPEDIEGFLG 191
            ||.|:||||||||| .||...|::|.::.|..:.|.||||. ||..:.||:.|.....||:.|||
Zfish   129 TFSTFGYALDPSVDTSQASSNSYIGAIEEAEKNKGLTVFETGPKKSEKRKKVKGGEAADIDNFLG 193

  Fly   192 PWGKFENEVSVAKPNEQERAELDELLSKRHKRGRIPEDKPLEEKSTLHIKDAYDYQGRSYLHAPH 256
            ||.|:::|..||||:|.|:.||||:.:||.|||:..|:.|.|||:.||||||||||||||||.|.
Zfish   194 PWAKYQDEKDVAKPSEDEQKELDEITAKRQKRGKNEEESPAEEKTVLHIKDAYDYQGRSYLHIPQ 258

  Fly   257 DLGVNLRSNAPPTKCFLPKAHIHTWSGHNKGISSIRWFPKTAHLLLSGSMDCRVKLWEVYGERRC 321
            |:|:||||...|.||:|||..:|.|:||.||:|:||.|||:.|||||.||||::||||||.||||
Zfish   259 DVGINLRSADIPDKCYLPKKQLHVWTGHTKGVSAIRLFPKSGHLLLSCSMDCKIKLWEVYNERRC 323

  Fly   322 IRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNSKQH 386
            :|||.||.:|::|:.:||.||.||||:|||||||||:|||..:||||.||:|:||||:||..||:
Zfish   324 VRTFIGHSKAVRDVCFNNSGTQFLSAAYDRYIKLWDSETGQCISRFTNRKVPYCVKFNPDEDKQN 388

  Fly   387 LFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTSDDKSMRIWEWDIPVDMK 451
            |.|||.|||||:.||.|||::|||||||||:|:||||||:|||||:||||||:|:||||||.|.|
Zfish   389 LLVAGMSDKKIVQWDIRSGEVVQEYDRHLGAVNTITFVDENRRFVSTSDDKSLRVWEWDIPADFK 453

  Fly   452 YIADPTMHSMPAVTLAPNGKWMACQSLDNKIVIFSALNRFKMNRKKTFTGHMVSGYACQLDFSPD 516
            |||:|:|||||||||:|||||:||||:||:|:||.|.|||::|:||.|.||||:|||||:|||||
Zfish   454 YIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPD 518

  Fly   517 MSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPHEASKVVTAGWDGQIKYWD 576
            |||:||||.|||..||||||||:|.:.:|||.|||||||||||.|||:|.|||||||.||
Zfish   519 MSYVVSGDADGKLNIWDWKTTKLYHRIKAHDKVCISALWHPHETSKVITCGWDGQIKLWD 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6015	NP_651005.1	WD40	<274..576	CDD:225201	218/301 (72%)
		WD40	277..576	CDD:238121	216/298 (72%)
		WD40 repeat	289..327	CDD:293791	28/37 (76%)
		WD40 repeat	332..368	CDD:293791	23/35 (66%)
		WD40 repeat	374..412	CDD:293791	25/37 (68%)
		WD40 repeat	418..453	CDD:293791	27/34 (79%)
		WD40 repeat	461..500	CDD:293791	27/38 (71%)
		WD40 repeat	509..532	CDD:293791	17/22 (77%)
cdc40	NP_001009990.1	WD40	<276..578	CDD:225201	218/301 (72%)
		WD40	280..578	CDD:238121	216/297 (73%)
		WD40 repeat	291..329	CDD:293791	28/37 (76%)
		WD40 repeat	334..370	CDD:293791	23/35 (66%)
		WD40 repeat	376..414	CDD:293791	25/37 (68%)
		WD40 repeat	420..502	CDD:293791	61/81 (75%)
		WD40 repeat	510..546	CDD:293791	27/35 (77%)
		WD40 repeat	552..577	CDD:293791	21/24 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596327
Domainoid	1	1.000	258	1.000	Domainoid score	I1968
eggNOG	1	0.900	-	-		E1_KOG0282
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5716
Inparanoid	1	1.050	759	1.000	Inparanoid score	I533
OMA	1	1.010	-	-		QHG55903
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004340
OrthoInspector	1	1.000	-	-		oto41274
orthoMCL	1	0.900	-	-		OOG6_102256
Panther	1	1.100	-	-	LDO	PTHR43979
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R987
SonicParanoid	1	1.000	-	-		X3608
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790