DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6015 and prp-17

DIOPT Version :9

Sequence 1:	NP_651005.1	Gene:	CG6015 / 42593	FlyBaseID:	FBgn0038927	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_492851.1	Gene:	prp-17 / 172999	WormBaseID:	WBGene00018625	Length:	567	Species:	Caenorhabditis elegans

Alignment Length:	584	Identity:	276/584 - (47%)
Similarity:	397/584 - (67%)	Gaps:	25/584 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGLQSYASSSDEESDHADAATATTNSEPSAPIPDHLLPVDKTHSLSKSIAVCAAPTVVPLGASA 65
            |..||:|..|..|.||. ||:........|:.:.:.              |:..||.|....|..
Worm     1 MDALQAYGGSDSEHSDD-DASMDQVAKGKSSTLLER--------------AIVTAPDVESKSAIR 50

  Fly    66 VPRTLDPTLKEVTYNPRYEEMYAPVKGPEHPDLTMQQRAPRNTLAGYVEKAHINAFEFENQRRTF 130
            ....:||..||:..||::::::.|..||.:...:.|||:.:|||.|:||.||:|.|.|..|.|:|
Worm    51 QVAIVDPKTKEIKSNPKFDQLFKPESGPVNHFKSEQQRSQKNTLTGFVEPAHLNEFHFNRQIRSF 115

  Fly   131 HTYGYALDPSVDDQADGQSFVGDLQSAYDDNGKTVFEPPK-AKKLRKQEKNDNPEDIEGFLGPWG 194
            .|.|||.:|:.  ::....||||::.|..:.|.::||..| ..:.||:.:||:..||:|:.|||.
Worm   116 DTLGYAQNPTA--ESGTTHFVGDVKKAEAEKGVSLFESKKTGGEKRKRVRNDDSADIDGYTGPWS 178

  Fly   195 KFENEVSVAKPNEQERAELDELLSKRHKRGR------IPEDKPLEEKSTLHIKDAYDYQGRSYLH 253
            :|.:|.:||||..:.:.::||::.||.::.|      ...::..||.||||:|:|.||||||:|.
Worm   179 RFIDEKTVAKPTPELQKQMDEIVKKRQEKSRRFKKEKEDSEQMAEESSTLHLKEAEDYQGRSFLV 243

  Fly   254 APHDLGVNLRSNAPPTKCFLPKAHIHTWSGHNKGISSIRWFPKTAHLLLSGSMDCRVKLWEVYGE 318
            .|...|||||.:..|.:||:||..:||:.|||||::.::||||:|||.||.|||.::||||||..
Worm   244 PPSFTGVNLREDYVPERCFVPKKLVHTYRGHNKGVNFLQWFPKSAHLFLSCSMDTKIKLWEVYDR 308

  Fly   319 RRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWDAETGDVVSRFTTRKMPFCVKFHPDNS 383
            :|.:||::||:..::::|:||.||.|||||:|||:||||.|||.|..||.|..:|:|:|:|||:.
Worm   309 QRVVRTYAGHKLPVREVAFNNEGTEFLSASFDRYVKLWDTETGQVKQRFHTGHVPYCLKYHPDDD 373

  Fly   384 KQHLFVAGTSDKKIICWDTRSGDIVQEYDRHLGSVSTITFVDDNRRFVTTSDDKSMRIWEWDIPV 448
            |.|:|:.|..:||||.||:|||:|||||||||.:|::|||.|.||||.:||||||:|||||:|||
Worm   374 KNHMFLVGMQNKKIIQWDSRSGEIVQEYDRHLQAVNSITFFDKNRRFASTSDDKSVRIWEWEIPV 438

  Fly   449 DMKYIADPTMHSMPAVTLAPNGKWMACQSLDNKIVIFSAL-NRFKMNRKKTFTGHMVSGYACQLD 512
            |.|.|.:..:|::|.:|.:||.||:..|.:||:||:|..: ::.:.::||.|.||..:||||.:|
Worm   439 DTKLIQNVGLHAIPTMTKSPNDKWVVGQCMDNRIVLFQLVDDKLRFSKKKAFRGHNAAGYACNID 503

  Fly   513 FSPDMSYLVSGDGDGKCYIWDWKTTKMYKKWQAHDGVCISALWHPHEASKVVTAGWDGQIKYWD 576
            ||||.|:|:|||.|||.:||||:|.|:..||:|||..||:|||||||.|:::||||||.||.|:
Worm   504 FSPDQSFLISGDADGKLFIWDWRTHKIVGKWKAHDSTCIAALWHPHEKSRMITAGWDGLIKMWN 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6015	NP_651005.1	WD40	<274..576	CDD:225201	174/302 (58%)
		WD40	277..576	CDD:238121	172/299 (58%)
		WD40 repeat	289..327	CDD:293791	21/37 (57%)
		WD40 repeat	332..368	CDD:293791	22/35 (63%)
		WD40 repeat	374..412	CDD:293791	22/37 (59%)
		WD40 repeat	418..453	CDD:293791	25/34 (74%)
		WD40 repeat	461..500	CDD:293791	14/39 (36%)
		WD40 repeat	509..532	CDD:293791	14/22 (64%)
prp-17	NP_492851.1	WD40	267..567	CDD:238121	172/299 (58%)
		WD40 repeat	279..317	CDD:293791	21/37 (57%)
		WD40 repeat	322..359	CDD:293791	23/36 (64%)
		WD40 repeat	364..402	CDD:293791	22/37 (59%)
		WD40 repeat	408..443	CDD:293791	25/34 (74%)
		WD40 repeat	451..491	CDD:293791	14/39 (36%)
		WD40 repeat	500..523	CDD:293791	14/22 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167549
Domainoid	1	1.000	181	1.000	Domainoid score	I2066
eggNOG	1	0.900	-	-		E1_KOG0282
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5716
Inparanoid	1	1.050	589	1.000	Inparanoid score	I538
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55903
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004340
OrthoInspector	1	1.000	-	-		oto19146
orthoMCL	1	0.900	-	-		OOG6_102256
Panther	1	1.100	-	-	LDO	PTHR43979
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R987
SonicParanoid	1	1.000	-	-		X3608
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790