DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13409 and TMEM181

DIOPT Version :9

Sequence 1:	NP_651004.1	Gene:	CG13409 / 42592	FlyBaseID:	FBgn0038926	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_011534302.1	Gene:	TMEM181 / 57583	HGNCID:	20958	Length:	528	Species:	Homo sapiens

Alignment Length:	435	Identity:	190/435 - (43%)
Similarity:	266/435 - (61%)	Gaps:	29/435 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AYQLPSGGLLLRLKSSLSQFSDLFSDFSRYISPAYHHDRCERSVHMRLYSMHKREFVMVFLGFFT 80
            |::.|   |...||....:..:.:.:....::| :..||..|...||||::.||.||:||:.||.
Human   103 AFEPP---LCSELKHLCRRLREAYRELKEDLTP-FKDDRYYRLAPMRLYTLSKRHFVLVFVVFFI 163

  Fly    81 CFGLGIVIGLTGPPITSTSSLTAQQILANTSLAHSPTVLGKGPFAMKSPLTTTYSQQMWLIAKLV 145
            ||||.|.:|:.||.:..||:       ||.||.:|..:   .|..:.|...:||:||:||...:.
Human   164 CFGLTIFVGIRGPKVIQTSA-------ANFSLNNSKKL---KPIQILSNPLSTYNQQLWLTCVVE 218

  Fly   146 TDNNDDERYDKSFQVSVSIDGINEQHKPQSVLGSGVAHNRTRHLVCV-------RNDCEEFTVMH 203
            .|.:.:.....||.::|.:||:.:......:  ....|||||.|.|.       ...|.|..|.|
Human   219 LDQSKETSIKTSFPMTVKVDGVAQDGTTMYI--HNKVHNRTRTLTCAGANLSVYLQKCAEIIVAH 281

  Fly   204 LGFLDYAHYIITVRFYGLESFHQKYNIRSITFYFKTYSPDFTQIEIWFRCIFLLFTFIVICWYAH 268
            ||:|:|..|.:.|.|.     |.|..|:.:.|.:|||:|.|:::|||||..|::.||||.|.:||
Human   282 LGYLNYTQYTVIVGFE-----HLKLPIKGMNFTWKTYNPAFSRLEIWFRFFFVVLTFIVTCLFAH 341

  Fly   269 TLRKYPIYDWSIEQRWLSVLLPLLLLYDNPFFPLIFLMNSWLPGMLDAILQATFLCALLMFWLCI 333
            :|||:.:.||.|||:|:||||||||||::|||||.||:|||||||||.:.|:.||||||:||||:
Human   342 SLRKFSMRDWGIEQKWMSVLLPLLLLYNDPFFPLSFLVNSWLPGMLDDLFQSMFLCALLLFWLCV 406

  Fly   334 YHGLR-QNERSFVRFYLVKVIVVLPIWLCAIVLATWEKCNELRDPTYSHFVDTKNYNGFKMFFYI 397
            |||:| |.||..:.|||.|..:|..:||.::.|..|:..|||.||.|.:.|||.|:.|.|:||.:
Human   407 YHGIRVQGERKCLTFYLPKFFIVGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGMKVFFMV 471

  Fly   398 ACCMYVLYLVLLLLRAYTELRSMPYFDMRLKFLTLLMLFVLSISI 442
            ...:|:|||:.|::||.:|||.|||.|:||||||.|...||.|.:
Human   472 VAAVYILYLLFLIVRACSELRHMPYVDLRLKFLTALTFVVLVIRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13409	NP_651004.1	MIG-14_Wnt-bd	195..492	CDD:284153	133/249 (53%)
TMEM181	XP_011534302.1	MIG-14_Wnt-bd	273..514	CDD:284153	132/245 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146873
Domainoid	1	1.000	358	1.000	Domainoid score	I976
eggNOG	1	0.900	-	-		E1_28HK3
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44787
Inparanoid	1	1.050	467	1.000	Inparanoid score	I1546
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54352
OrthoDB	1	1.010	-	-		D299250at33208
OrthoFinder	1	1.000	-	-		FOG0008295
OrthoInspector	1	1.000	-	-		oto91283
orthoMCL	1	0.900	-	-		OOG6_105414
Panther	1	1.100	-	-	LDO	PTHR31918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5374
SonicParanoid	1	1.000	-	-		X6278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800