DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13409 and tmem181

DIOPT Version :9

Sequence 1:	NP_651004.1	Gene:	CG13409 / 42592	FlyBaseID:	FBgn0038926	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_005168570.1	Gene:	tmem181 / 557799	ZFINID:	ZDB-GENE-060503-309	Length:	530	Species:	Danio rerio

Alignment Length:	534	Identity:	253/534 - (47%)
Similarity:	350/534 - (65%)	Gaps:	28/534 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LLLRLKSSLSQFSDLFSDFSRYISPAYHHDRCERSVHMRLYSMHKREFVMVFLGFFTCFGLGIVI 88
            |:..:|......::..::....::| |.::|..|...||||::.||.||:||:.||.||||..:|
Zfish    15 LVGEMKRFCRNITEACNELKEELTP-YRNERFYRLAPMRLYTLSKRHFVLVFVVFFFCFGLSTLI 78

  Fly    89 GLTGPPITSTSSLTAQQILANTSLAHSPTVLGKGPFAMKSPLTTTYSQQMWLIAKLVTDNNDDER 153
            ||:||.|.|.:..        ..|:.||.....||||..||..:.|:||:||...:...||..:.
Zfish    79 GLSGPKIISENHY--------NGLSVSPNGSKIGPFAFSSPPLSNYNQQLWLTCIIELQNNIVDL 135

  Fly   154 YDKSFQVSVSIDGINEQHKPQSVLGSGVAHNRTRHLVCVRND--CEEFTVMHLGFLDYAHYIITV 216
            ..:.|.::|.:.|:.:......:  |...|||.|.|.|..:.  |:|..|:|||:|:|..|.|.|
Zfish   136 SWREFGMNVELQGVVQDTSVMRI--SDNVHNRNRSLHCSAHQQACDEIIVLHLGYLNYTQYKINV 198

  Fly   217 RFYGLESFHQKYNIRSITFYFKTYSPDFTQIEIWFRCIFLLFTFIVICWYAHTLRKYPIYDWSIE 281
            .|..|:. ..|.||:::||.||.|...|:|:|||||.:|::.||||.|.:||:|||:.:.||.||
Zfish   199 SFRNLQD-DLKDNIKNVTFVFKMYQDTFSQMEIWFRFVFVVMTFIVTCMFAHSLRKFSMRDWGIE 262

  Fly   282 QRWLSVLLPLLLLYDNPFFPLIFLMNSWLPGMLDAILQATFLCALLMFWLCIYHGLR-QNERSFV 345
            |:|:|:||||||||::|||||.||:|||.||.|||.|||.||||||:||||:|||:| |.||.|:
Zfish   263 QKWMSILLPLLLLYNDPFFPLSFLVNSWFPGTLDAFLQAVFLCALLLFWLCVYHGIRVQGERRFL 327

  Fly   346 RFYLVKVIVVLPIWLCAIVLATWEKCNELRDPTYSHFVDTKNYNGFKMFFYIACCMYVLYLVLLL 410
            .|||.|:::|..:||.|:.|..|:..|||:||||.:.||.:|:.|.|:||.:..|:||||||.|:
Zfish   328 TFYLPKLLMVGLLWLSAVTLGIWQTVNELQDPTYQYKVDIQNFQGMKIFFLLVVCVYVLYLVFLV 392

  Fly   411 LRAYTELRSMPYFDMRLKFLTLLMLFVLSISITVTTCRFGFGILEDNFVASLNTTYRSSAQFMCF 475
            :||.:||::|||.|:||||||.|.|.||.||:.:...|||...|:|||||.|:|.|::||:|:.|
Zfish   393 VRACSELKNMPYSDLRLKFLTALTLVVLVISVIILYLRFGSKALQDNFVAELSTHYQNSAEFLSF 457

  Fly   476 YGLLNFYLYTMAYVYSPD-GRFAQAELAVTKDNPAISMIDDSDEDVVYGSDEESRRPLTSVGGGA 539
            ||||||||||:|:||||. .....::|   |||||.||::|||::|:||||.| ..||.:  |.|
Zfish   458 YGLLNFYLYTLAFVYSPSKNALYDSQL---KDNPAFSMLNDSDDEVIYGSDYE-EMPLQN--GRA 516

  Fly   540 GK------NDYDSD 547
            .|      ::.|||
Zfish   517 IKATAKYQDESDSD 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13409	NP_651004.1	MIG-14_Wnt-bd	195..492	CDD:284153	171/299 (57%)
tmem181	XP_005168570.1	MIG-14_Wnt-bd	178..476	CDD:284153	173/298 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580325
Domainoid	1	1.000	374	1.000	Domainoid score	I839
eggNOG	1	0.900	-	-		E1_28HK3
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44787
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1429
OMA	1	1.010	-	-		QHG54352
OrthoDB	1	1.010	-	-		D299250at33208
OrthoFinder	1	1.000	-	-		FOG0008295
OrthoInspector	1	1.000	-	-		oto41769
orthoMCL	1	0.900	-	-		OOG6_105414
Panther	1	1.100	-	-	LDO	PTHR31918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5374
SonicParanoid	1	1.000	-	-		X6278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800