DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ND-42 and Ndufa10

DIOPT Version :9

Sequence 1:	NP_001262821.1	Gene:	ND-42 / 42591	FlyBaseID:	FBgn0019957	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_955789.2	Gene:	Ndufa10 / 678759	RGDID:	727968	Length:	355	Species:	Rattus norvegicus

Alignment Length:	362	Identity:	136/362 - (37%)
Similarity:	207/362 - (57%)	Gaps:	37/362 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GGPRVPKAAPYPYKTKKYSVFNAIF-DKTSKRFDENSKVICVEGPIAAGKSKFAKELAEELDMEY 110
            |..||.:.....:...:|.:..:|. |||:|:..|.|:||.|:|.|.:||:|.|:::||:|.|::
  Rat    21 GAQRVGRIHTSVHCKLRYGLLASILGDKTTKKLHEYSRVITVDGNICSGKNKLARDIAEQLGMKH 85

  Fly   111 YPAVDLDLIYINSYGYDMRKLDPQLPPSCRSYDVRNFCLDPSHDLAAQFQIR--MYMLRYSQYID 173
            ||...:.  |.:|...|.|.||.:...||   .:..|..:|..:....::::  :|..|..||.|
  Rat    86 YPEAGIQ--YSSSTTGDGRPLDIEFSGSC---SLEKFYDNPKSNDGNSYRLQSWLYASRLLQYSD 145

  Fly   174 ALQHVLSTGQGVVLERSPYSDFVFMEAMFRQGYLSRGARSVYNELRQNTIGELLKPHLVIYLDLP 238
            ||:|:||||||||||||.||||||:|||:.||::.:.....|||:::.|:.|.|.||.|||:|:|
  Rat   146 ALEHLLSTGQGVVLERSIYSDFVFLEAMYNQGFIRKQCVDHYNEIKRLTLPEYLPPHAVIYIDVP 210

  Fly   239 VDAVKKQIKARNVDYEVQSKVFSDAYLSDLEQLYKQQYLKDISTHAELLIY-DWTAGGETEVVVE 302
            |..::.:|:.:...:|:  ||.| |||.|:|..||:.:|..:|...|:|:| .|.|...|: |||
  Rat   211 VSEIQSRIQKKGDPHEM--KVTS-AYLQDIEDAYKKTFLPKMSEICEVLVYSSWEAEDSTK-VVE 271

  Fly   303 DIERIDFN------QFEADIHNKKMLDWRFPLEAEWCEARIKYCHEKPDLMNYFNVPRFDVPELV 361
            |||.:::|      |.:...||.:||                 ..:|.:::||..||.: :||:.
  Rat   272 DIEYLNYNKGPWLKQDDRTFHNLRML-----------------VQDKREVLNYTTVPVY-LPEIT 318

  Fly   362 RSADDGKVWRDVWFNAPGMKYRPGYNADMGDEGLLTK 398
            ..|..|....|.:...||.||.||||||:||:.:..|
  Rat   319 IGAHQGSRIYDSFRELPGRKYAPGYNADVGDKWIWLK 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND-42	NP_001262821.1	NDUO42	84..308	CDD:238988	96/226 (42%)
Ndufa10	NP_955789.2	NDUO42	59..277	CDD:238988	96/226 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346704
Domainoid	1	1.000	161	1.000	Domainoid score	I3928
eggNOG	1	0.900	-	-		E1_COG1428
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15342
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3557
OMA	1	1.010	-	-		QHG45505
OrthoDB	1	1.010	-	-		D1147235at2759
OrthoFinder	1	1.000	-	-		FOG0006118
OrthoInspector	1	1.000	-	-		otm45448
orthoMCL	1	0.900	-	-		OOG6_107081
Panther	1	1.100	-	-	LDO	PTHR10513
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4410
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770