DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ND-42 and NDUFA10

DIOPT Version :9

Sequence 1:	NP_001262821.1	Gene:	ND-42 / 42591	FlyBaseID:	FBgn0019957	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001308948.1	Gene:	NDUFA10 / 4705	HGNCID:	7684	Length:	375	Species:	Homo sapiens

Alignment Length:	308	Identity:	108/308 - (35%)
Similarity:	180/308 - (58%)	Gaps:	29/308 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KYSVFNAIF-DKTSKRFDENSKVICVEGPIAAGKSKFAKELAEELDMEYYPAVDLDLIYINSYGY 126
            :|.:::.:. ||.|||..|.|:||.|:|.|..||.|.|||:||:|..:::|  :..:.|.:|...
Human    37 RYGMWHFLLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFP--EAGIHYPDSTTG 99

  Fly   127 DMRKLDPQLPPSCRSYDVRNFCLDPSHDLAAQFQIR--MYMLRYSQYIDALQHVLSTGQGVVLER 189
            |.:.|......:|   .:..|..||..:....::::  :|..|..||.|||:|:|:|||||||||
Human   100 DGKPLATDYNGNC---SLEKFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLER 161

  Fly   190 SPYSDFVFMEAMFRQGYLSRGARSVYNELRQNTIGELLKPHLVIYLDLPVDAVKKQIKARNVDYE 254
            |.:|||||:|||:.||::.:.....|||::..||.:.|.||||||:|:||..|:::|:.:...:|
Human   162 SIFSDFVFLEAMYNQGFIRKQCVDHYNEVKSVTICDYLPPHLVIYIDVPVPEVQRRIQKKGDPHE 226

  Fly   255 VQSKVFSDAYLSDLEQLYKQQYLKDISTHAELLIYDWTAGGETEVVVEDIERIDFNQ---FEADI 316
            ::   .:.|||.|:|..||:.:|.::|...|:|.|......:::.||||||.:.|::   .:.|
Human   227 MK---ITSAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAQDSKKVVEDIEYLKFDKGPWLKQD- 287

  Fly   317 HNKKMLDWRFPLEAEWCEARIKYCHEKPDLMNYFNVPRFDVPELVRSA 364
             |:.:...|..::            :|.:::||.::|.| :||:...|
Human   288 -NRTLYHLRLLVQ------------DKFEVLNYTSIPIF-LPEVTIGA 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND-42	NP_001262821.1	NDUO42	84..308	CDD:238988	88/225 (39%)
NDUFA10	NP_001308948.1	NDUO42	59..277	CDD:238988	88/225 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153101
Domainoid	1	1.000	154	1.000	Domainoid score	I4275
eggNOG	1	0.900	-	-		E1_COG1428
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15342
Inparanoid	1	1.050	189	1.000	Inparanoid score	I3902
Isobase	1	0.950	-	0	Normalized mean entropy	S5795
OMA	1	1.010	-	-		QHG45505
OrthoDB	1	1.010	-	-		D1147235at2759
OrthoFinder	1	1.000	-	-		FOG0006118
OrthoInspector	1	1.000	-	-		oto89975
orthoMCL	1	0.900	-	-		OOG6_107081
Panther	1	1.100	-	-	LDO	PTHR10513
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3846
SonicParanoid	1	1.000	-	-		X4410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750