DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cchl and CYC3

DIOPT Version :9

Sequence 1:	NP_001262820.1	Gene:	Cchl / 42590	FlyBaseID:	FBgn0038925	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_009361.1	Gene:	CYC3 / 851192	SGDID:	S000000037	Length:	269	Species:	Saccharomyces cerevisiae

Alignment Length:	265	Identity:	110/265 - (41%)
Similarity:	143/265 - (53%)	Gaps:	44/265 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EATKSVPVDHAKYMSGSGAPPPECP-MHQKHGDAKSASAVPPHPKMQAASECPV-QHDNSDVNPL 74
            :.|....:..|...|.||     || ||:      |:|:.||      :||||| |.||..:|||
Yeast     8 QKTTGKDIGGAAVSSMSG-----CPVMHE------SSSSSPP------SSECPVMQGDNDRINPL 55

  Fly    75 NMMP--PANQQPAADQPFPLPTDRQTSTIPKVTEDGSVQFWQYPSQQMFWNAMLRKGWRWKTEDV 137
            |.||  .|::||.  |...||.||..|:|||..:  |.:||:|||.|..:|||:|||....:.:|
Yeast    56 NNMPELAASKQPG--QKMDLPVDRTISSIPKSPD--SNEFWEYPSPQQMYNAMVRKGKIGGSGEV 116

  Fly   138 SQKDMGDIIRIHNANNEQAWQEVLKWEALHAKECG-NPRLKSFGGKAKDFSPRAR--------FR 193
            ::..:..::::||..||..|||||:||..|..|.. .|:|..|.||....|||||        |.
Yeast   117 AEDAVESMVQVHNFLNEGCWQEVLEWEKPHTDESHVQPKLLKFMGKPGVLSPRARWMHLCGLLFP 181

  Fly   194 SWLGYELPFDRHDWIVDR----------CGKDVRYVIDYYDGGLVDKDYRFALLDVRPAMDSVDN 248
            |....|||||||||||.|          ..|:||||:|:|.|...:.......:|||||:||:||
Yeast   182 SHFSQELPFDRHDWIVLRGERKAEQQPPTFKEVRYVLDFYGGPDDENGMPTFHVDVRPALDSLDN 246

  Fly   249 VWDRM 253
            ..|||
Yeast   247 AKDRM 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cchl	NP_001262820.1	Cyto_heme_lyase	13..260	CDD:279589	110/264 (42%)
CYC3	NP_009361.1	Cyto_heme_lyase	1..253	CDD:396015	110/265 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346685
Domainoid	1	1.000	159	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E1_KOG3996
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31438
Inparanoid	1	1.050	158	1.000	Inparanoid score	I1069
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003033
OrthoInspector	1	1.000	-	-		oto100279
orthoMCL	1	0.900	-	-		OOG6_101849
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1787
SonicParanoid	1	1.000	-	-		X2384
TreeFam	1	0.960	-	-
	13	12.680