DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cchl and HCCS

DIOPT Version :9

Sequence 1:	NP_001262820.1	Gene:	Cchl / 42590	FlyBaseID:	FBgn0038925	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	XP_024308136.1	Gene:	HCCS / 3052	HGNCID:	4837	Length:	288	Species:	Homo sapiens

Alignment Length:	267	Identity:	146/267 - (54%)
Similarity:	183/267 - (68%)	Gaps:	33/267 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SVPVDHAK----------YMSGSGAP------PPECPMHQKHGDAKSASAVPPH-PKMQAASECP 63
            |.|::..:          |:..||.|      .|.|        .|...:||.| .:.....|||
Human    31 SAPIERVRCPAFMVTPFLYLIISGCPVNTEPSGPTC--------EKKTYSVPAHQERAYEYVECP 87

  Fly    64 VQ----HDNSDVNPLNMMPPANQQPAADQPFPLPTDRQTSTIPKVTEDGSVQFWQYPSQQMFWNA 124
            ::    .:..:::|.|:|||.||.||.||||.|.|.|:.|:||:.   .|.:.|.|||:||||||
Human    88 IRGTAAENKENLDPSNLMPPPNQTPAPDQPFALSTVREESSIPRA---DSEKKWVYPSEQMFWNA 149

  Fly   125 MLRKGWRWKTEDVSQKDMGDIIRIHNANNEQAWQEVLKWEALHAKECG-NPRLKSFGGKAKDFSP 188
            ||:|||:||.||:|||||.:||||||.||||||:|:||||||||.||. .|.|..||||||::||
Human   150 MLKKGWKWKDEDISQKDMYNIIRIHNQNNEQAWKEILKWEALHAAECPCGPSLIRFGGKAKEYSP 214

  Fly   189 RARFRSWLGYELPFDRHDWIVDRCGKDVRYVIDYYDGGLVDKDYRFALLDVRPAMDSVDNVWDRM 253
            |||.|||:||||||||||||::|||.:|||||||||||.|:|||:|.:||||||:||:..|||||
Human   215 RARIRSWMGYELPFDRHDWIINRCGTEVRYVIDYYDGGEVNKDYQFTILDVRPALDSLSAVWDRM 279

  Fly   254 RVAYMRW 260
            :||:.||
Human   280 KVAWWRW 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cchl	NP_001262820.1	Cyto_heme_lyase	13..260	CDD:279589	144/265 (54%)
HCCS	XP_024308136.1	Cyto_heme_lyase	53..286	CDD:307431	141/243 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160149
Domainoid	1	1.000	294	1.000	Domainoid score	I1502
eggNOG	1	0.900	-	-		E1_KOG3996
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2645
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54750
OrthoDB	1	1.010	-	-		D1282808at2759
OrthoFinder	1	1.000	-	-		FOG0003033
OrthoInspector	1	1.000	-	-		oto91555
orthoMCL	1	0.900	-	-		OOG6_101849
Panther	1	1.100	-	-	LDO	PTHR12743
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1787
SonicParanoid	1	1.000	-	-		X2384
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800