Protein Alignment Mitofilin and MIC60

DIOPT Version :9

• Sequence 1: NP_001262819.1
• Gene: Mitofilin / 42587
• FlyBaseID: FBgn0019960
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_012941.1
• Gene: MIC60 / 853886
• SGDID: S000001724
• Length: 540
• Species: Saccharomyces cerevisiae
• Alignment Length: 511
• Identity: 78/511 - (15%)
• Similarity: 190/511 - (37%)
• Gaps: 120/511 - (23%)

  Fly   271 WTTLKNRASARDTAVATAERAAREAQEKIVACEIALSAAATAQNAKKVEAVRDKIKKLVDHIGNV 335
            |..||.:::...:.:..:.:..|..:|.|...:|........:.......:::.|..|.|.|.::
Yeast    96 WDGLKAKSNDLLSGLTGSSQTRRSNRENIEVKKILSLEPLNIETENSDPQLKEIIGSLNDLINSL 160

  Fly   336 KDELYRHKDTASVSDKYWRNVEKARNYFIDEIESIFPGLSLADKKLNLSKEDLDLFILHAYTHVL 400
            .|      ...|:.:..:.:::|:.       :::...||..::.|   ||.|..:::...:.|:
Yeast   161 ND------SNLSIPESEFNSIKKSN-------QNMLTNLSQLNETL---KEALSNYMIQRTSEVI 209

  Fly   401 A-----YQKELQRLQTDGELRLKRAIDSVRGDNDSEALRAQLEYHLEAERRKLAVENQKKIFHIH 460
            .     |:...:..:.:.:..|.:.:|..: :|.::....:||..|:|....|..::..::..:.
Yeast   210 TELNTQYENSKREFEKNLQKNLLQEVDEFK-ENLTKQKDKELEEKLKANEELLQAKHANEVGLLS 273

  Fly   461 ----AESDKLLRLQLKKQAEAHADHIKDIVAQRETDLTRSFKRELEDKLATEKANYKLQLAGMLG 521
                .|.:|:::.:::|:......|:::|.:: ..||::|..|.                    .
Yeast   274 ITQVKEFNKIIKDKIEKERNGRLAHLEEINSE-VNDLSKSIDRS--------------------S 317

  Fly   522 KLRGMDAALAEIE---DEFQERADAERTANQAQALWAACQALWASVRAATPGVHYK---DRLRPL 580
            |:...:.||.::.   ||.:.|.:...                      .|.|:..   .||:.|
Yeast   318 KILSKNEALVQLTFQVDEIKSRINNNN----------------------LPDVNIDKELSRLKLL 360

  Fly   581 KNEINAIAKVAKGDD-------------------------------LVAAVLESVPKEAQERGVY 614
            .|.::...|.:..||                               |::..|:.:......:.:.
Yeast   361 SNLLSTFNKKSCCDDGDCCSCKKGNKNEGKEGKISCKCKPKTNPPSLLSVALDELESTCSGKKIL 425

  Fly   615 PEDALRERFLNVERVARRLALVPEEGAGLPIYFLSYLQSLFIL-RPDNPISKDELENKPFDYSKL 678
            ..:.:..|:..:....:..:|:| ..:|:.....:.:.|||:. :..||.:..:.::
Yeast   426 SNEQIYNRWNLLADDFKTASLLP-PNSGILGQLTAKVFSLFLFTKTGNPSNATDFDS-------- 481

  Fly   679 DTYDILNRARYHVDRSDFLQALKYMNLLQGASRKIAGEWMKEARLMLETQQAANTL 734
                :..|...::..|:...|::.:..|:|...|:...|:::||..||.|:....|
Yeast   482 ----VYARVGDNLRVSNLNDAVEEVVSLKGWPHKVCESWIEDARRKLEVQRLVEIL 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitofilin	NP_001262819.1	Mitofilin	68..739	CDD:286774	78/511 (15%)
MIC60	NP_012941.1	Mitofilin	<130..533	CDD:370640	70/475 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344489
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1854
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103871
Panther	1	1.100	-	-	LDO	PTHR15415
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4607
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860