DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mitofilin and Immt

DIOPT Version :9

Sequence 1:	NP_001262819.1	Gene:	Mitofilin / 42587	FlyBaseID:	FBgn0019960	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_083949.2	Gene:	Immt / 76614	MGIID:	1923864	Length:	757	Species:	Mus musculus

Alignment Length:	770	Identity:	208/770 - (27%)
Similarity:	347/770 - (45%)	Gaps:	162/770 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 AGFGKVVLFVSPLAAVGGVITYAKYDDDFRKLVEKNVPGAGSVIKVALQEEPPFKGITKNVNDQI 133
            ||.|  :|||.  ..:||.|.|||:|..||:.|||.:|.:..:..:.|...|....:.|.
Mouse    47 AGAG--LLFVG--GGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPLPKK----- 102

  Fly   134 DKVKSGIETVTSTVDSVTSKVTGLFGGGSGDDKSKKSKVEPVKATPAEEKRPSKPSEVSKTEAKP 198
             .|:||...::|.                 .:..|.||: ||  ..:::.:...|:..:.|.|..
Mouse   103 -PVQSGPLKISSV-----------------SEVMKDSKL-PV--AQSQKTKGDTPASAASTGAAQ 146

  Fly   199 VSKPA--AAAAPAPAAK---------PKDNPLPRDVVELEKAI----------ELSAQLAVKE-- 240
            :...|  ..:.||||.:         |..|.........|:|.          |::|:||.:|
Mouse   147 IISAAGDTLSVPAPAVQHEDTIKTECPNTNEGKSTSETTEEAFSSSVRERPPEEVAARLAQQEKQ 211

  Fly   241 -----------------------------YNVAIGVLKGFNDDVRKVVDKAVENGE--NSLWTTL 274
                                         .|.|:..:|..::.::..:|.:...||  ::.|.|:
Mouse   212 EQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTV 276

  Fly   275 KNRASARDTAVATAERAAREAQEKIVACEIALSAAATAQNAKK---------VEAVRDKIKKLVD 330
            :.....|..||..|..|..:|:|::...:..:      ::|||         :.|...::..::.
Mouse   277 EGALKERRKAVDEAADALLKAKEELEKMKTII------EDAKKREIAGATPHITAAEGRLHNMIV 335

  Fly   331 HIGNVKDELYRHKDTASVSDKYWRNVEKARNYFIDEIESIFP-------GLSLADKKLNLSKEDL 388
            .:.||..::...:..|.|..:|...|.:||:.|..|::||.|       |:|::|....||.:||
Mouse   336 DLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKLSTDDL 400

  Fly   389 DLFILHAYTHV------LAYQK--ELQRLQTDGE---LRLKRAIDSVRGDNDSEALRAQLEYHLE 442
            :..|.||:..:      ||.||  |.|.::...|   |..||..||        |:...||:|
Mouse   401 NSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDS--------AVAKALEHH-- 455

  Fly   443 AERRKLAVENQKKIFHIHAESDKLLRLQLKKQAEAHADHIKDIVAQRETDLTRSFKRELEDKLAT 507
              |.::..|..:|:..:....:..:|.||::||.||.||::|::..:|.:|...|::.|.:||:.
Mouse   456 --RSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSE 518

  Fly   508 EKANYK-----------LQLAGMLGKLRGMDAALAEIEDEFQERADAERTANQAQALWAACQALW 561
            ::..::           |.:.....:|||       ||...|..|.||..|.:|..||.:.:||.
Mouse   519 QELEFRRRSQEQMDSFTLDINTAYARLRG-------IEQAVQSHAVAEEEARKAHQLWLSVEALK 576

  Fly   562 ASVR---AATPGVHYKDRLRPLKNEINAIAKVAKGDDLVAAVLESVPKEAQERGVYPEDALRERF 623
            .|::   |..|.:       ||.:.:.||......::...|:..::|.|:..||||.|:.||.||
Mouse   577 YSMKTSSAEMPTI-------PLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARF 634

  Fly   624 LNVERVARRLALVPEEGAGLPIYFLSYLQSLFILRPDNPISKDELENKPFDYSKLDTYDILNRAR 688
            ..|:::|||:|::.|....|..|||||||||.:..|..  .|...|..|.|   ::|:.:|:.|.
Mouse   635 YAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQ--LKPPAELYPED---INTFKLLSYAS 694

  Fly   689 YHVDRSDFLQALKYMNLLQGASRKIAGEWMKEARLMLETQQAANTLMAHAAASGL 743
            |.::..|...|.|::|.|:|.||::|.:|:||||:.|||:|....|.|:|:|.|:
Mouse   695 YCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASAVGI 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitofilin	NP_001262819.1	Mitofilin	68..739	CDD:286774	205/764 (27%)
Immt	NP_083949.2	Mitofilin	43..745	CDD:286774	205/764 (27%)
Immt	NP_083949.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..199		4/34 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840839
Domainoid	1	1.000	233	1.000	Domainoid score	I2394
eggNOG	1	0.900	-	-		E1_KOG1854
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38234
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3380
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48742
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005100
OrthoInspector	1	1.000	-	-		oto92171
orthoMCL	1	0.900	-	-		OOG6_103871
Panther	1	1.100	-	-	LDO	PTHR15415
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4607
SonicParanoid	1	1.000	-	-		X4724
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790