DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mitofilin and immt

DIOPT Version :9

Sequence 1:	NP_001262819.1	Gene:	Mitofilin / 42587	FlyBaseID:	FBgn0019960	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001001401.1	Gene:	immt / 327206	ZFINID:	ZDB-GENE-030131-5417	Length:	757	Species:	Danio rerio

Alignment Length:	814	Identity:	206/814 - (25%)
Similarity:	348/814 - (42%)	Gaps:	148/814 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AVRDQCKCA------LQRTLQQTTANNRQFGGSSSGSGGREQGRRQQEEQGQQGDQGYQGYQSLP 63
            |...||.|.      ||...:.|||.|   .|||:
Zfish    11 AAARQCVCGKVKAHPLQHCRRYTTAGN---SGSSA------------------------------ 42

  Fly    64 PHMREAGFGKVVL--FVSPLAAVGGVITYAKYDDDFRKLVEKNVP----------GAGSVIKVAL 116
                    ||:|.  .::....:||.|.|||:|..||..:||:||          ||.....|.:
Zfish    43 --------GKIVAASLLTVGGGLGGTILYAKWDPKFRSSIEKSVPYSDQLFDMVLGAPPSPPVPI 99

  Fly   117 QEEP---------PFKGITKNVNDQIDKVKSGIETVTSTVDSVTSKVTGLFGGGSGDDKSKK--- 169
            |::|         .....||:......|.|........:|:...:....|   .|.::.|.:
Zfish   100 QKKPETVKPLQISSLSEATKDSKQPKAKAKKSDPAPPPSVEEAPAPAPAL---QSLEEASAEAAH 161

  Fly   170 -----SKVEPVKATPAEEKRPSKPSEVSKTEAKPVSKPAAAAAPAPAAKPKDNPLPRDVVELEKA 229
                 |:|..|.|....::.||..|..::...|..::|..|....||.:.......:|..||:..
Zfish   162 IISAISEVPSVPAPGTSDESPSGHSAAAEECCKECTEPEPAVKERPAEEVTARLAQQDKAELDAL 226

  Fly   230 IELSAQL-------------AVKEYNVAIGVLKGFNDDVRKVVDKAV---ENGENSLWTTLKNRA 278
            ..|:|.|             |:.....|:..:....|.:|:.:|...   |....:|...|..||
Zfish   227 AALTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKLREAMDSETPPDEKSTQALNEALNERA 291

  Fly   279 SARDTAVATAERAAREAQEKIVACEIALSAAATAQNAKKVEAVRDKI--------KKLVDHIGNV 335
            .|.|.|.....:|..|.::        |.:........|:::.|.:|        ..:|| :..|
Zfish   292 RAVDDAGEALFKAKGELEK--------LRSVIDKAKQSKIDSARPQILAAEENLHSMIVD-LDKV 347

  Fly   336 KDELYRHKDTASVSDKYWRNVEKARNYFIDEIESIFPGLSLADKKLN--LSKEDLDLFILHAYTH 398
            ..::...:..|.:..:|...|.:|:..|..|:.:|.|.:....|.|:  ||.:||:..|.||:..
Zfish   348 VTKVQTAQSEAKIVSQYSELVNEAKAQFQQELANITPEIQANWKGLSGKLSADDLNSLIAHAHRR 412

  Fly   399 VLAYQKELQRLQTDGELRLKRAIDSVRGDNDSEALRAQLEYHLEAERRKLAVENQKKIFHIHAES 463
            :....:||...:...::.::.|::..:.::.....||.:. .||..|..:.:|.:||:..:....
Zfish   413 IDQLNRELAEQRVREQIHIEVALEQQKLEDQKAQERAVIS-ALEHSREDMRLEQEKKVQEVREVM 476

  Fly   464 DKLLRLQLKKQAEAHADHIKDIVAQRETDLTRSFKRELEDKLATEKANYK-----------LQLA 517
            :..:|.||::||.||.||::|::..:|.:|....:..|..|:..::.:|:           |.:.
Zfish   477 EAEMRTQLRRQAAAHTDHLRDVLKVQEQELREEAQEILNSKMMEQETHYRRLTQEQLDTFTLDMN 541

  Fly   518 GMLGKLRGMDAALAEIEDEFQERADAERTANQAQALWAACQALWASVRAA---TPGVHYKDRLRP 579
            ....:|:|       ||:.......||..|.:|..||.:.:||..::::|   :|       ..|
Zfish   542 AAYARLKG-------IEEAIDSHVIAEEEARKAHQLWLSVEALNYTLKSAGADSP-------TEP 592

  Fly   580 LKNEINAIAKVAKGDDLVAAVLESVPKEAQERGVYPEDALRERFLNVERVARRLALVPEEGAGLP 644
            |:..:.||.:....::...|:..::|:|:..||:|.|.:||.||.::.|:|||:||:.|....|.
Zfish   593 LEGAVRAIKESCAENEFAQALAIAIPEESLNRGIYSEASLRARFYDIRRLARRVALIDETRNSLY 657

  Fly   645 IYFLSYLQSLFILRPDNPISKDELENKPFDYSKLDTYDILNRARYHVDRSDFLQALKYMNLLQGA 709
            .||||||||:.:...|......:|  .|.|   |||:.:|..|.|.::|.|...|.|::|.|:|.
Zfish   658 QYFLSYLQSVLLFERDQEAPPAKL--APED---LDTFKLLAYATYSIERGDLELAAKFVNQLRGE 717

  Fly   710 SRKIAGEWMKEARLMLETQQAANTLMAHAAASGL 743
            |:::|.:|:|||||.|||:|..:.|.|:|.|.||
Zfish   718 SQRVAQDWLKEARLTLETKQVISLLSAYANAVGL 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitofilin	NP_001262819.1	Mitofilin	68..739	CDD:286774	189/739 (26%)
immt	NP_001001401.1	Mitofilin	39..747	CDD:286774	192/777 (25%)
		GBP_C	<418..522	CDD:303769	25/104 (24%)
		coiled coil	490..505	CDD:293879	6/14 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585309
Domainoid	1	1.000	226	1.000	Domainoid score	I2464
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38234
Inparanoid	1	1.050	230	1.000	Inparanoid score	I3427
OMA	1	1.010	-	-		QHG48742
OrthoDB	1	1.010	-	-		D1073064at2759
OrthoFinder	1	1.000	-	-		FOG0005100
OrthoInspector	1	1.000	-	-		oto39723
orthoMCL	1	0.900	-	-		OOG6_103871
Panther	1	1.100	-	-	LDO	PTHR15415
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4607
SonicParanoid	1	1.000	-	-		X4724
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940