DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mitofilin and immt-2

DIOPT Version :9

Sequence 1:	NP_001262819.1	Gene:	Mitofilin / 42587	FlyBaseID:	FBgn0019960	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_507241.2	Gene:	immt-2 / 180122	WormBaseID:	WBGene00012315	Length:	654	Species:	Caenorhabditis elegans

Alignment Length:	727	Identity:	157/727 - (21%)
Similarity:	292/727 - (40%)	Gaps:	177/727 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 AAVGGVITYAKYDDDFRKLVEKNVPGAGSVIKVAL-QEEPPFKGI-------------------- 125
            |...||..||.||::|||.:|..:||:.:::...: :||||...:
Worm    36 AGAAGVAGYASYDNEFRKKLEGVIPGSRTILNYTIGEEEPPAPRLKDLRPLQYSADPKVPPKPFE 100

  Fly   126 TKNVNDQIDKVKSGIETVTSTVDSVTSKVTGLFGGGSGDDKSKKSKVEPVKATPAEEKRPSKPSE 190
            .|.|..::..||..::..|                            ||.|.    ||:|..|..
Worm   101 PKPVKKELIGVKENLKETT----------------------------EPKKI----EKKPENPYI 133

  Fly   191 VSKTEAKPVSKPAAAAAPAPAAKPKDNPLPRDVVELEKAIELSAQLAVK-----EYNVAIGVLKG 250
            .:||...|..:          .:.....|...:.:.|||.:::....::     |::|
Worm   134 GAKTPLNPQER----------NEKLTESLKNHLTQAEKATKVATSAKLETIRAIEHHV------- 181

  Fly   251 FNDDVRKVVDKAVENGENSLWTTL------KNRASARDTAVATAERAAREAQEKIVACEIALSAA 309
                  :.:.:|:|.|::..|.::      ..|.:.:|   ..||:.||.|...:|. |..|...
Worm   182 ------QTIREAIEAGKDGDWDSVTVAHLKAKRLAEKD---EKAEKLARNAVADLVT-EANLGGQ 236

  Fly   310 ATAQNAKKV----EAVRDKIKKLVDH-IGNVKDELYRHKDTASV-----SDKYWRNVEKARNYFI 364
            ........:    :|..:|:...:|. |.|||     |.|:..:     ||:    |.::|..|.
Worm   237 GETTQLNPLVPISKATAEKLSNELDEMISNVK-----HVDSERIFVHDYSDR----VAESRRKFQ 292

  Fly   365 DEIESIFPGLSLADKKLNLSKEDLDLFILHAYTHVLAYQKELQRLQTDGELRLKRAIDSVRGDND 429
            .|::::.|.|:..| .:.:.|.||...:.||:..:    .:|.:...|.:|..::.|.|:.....
Worm   293 MELKAVHPNLNYED-GMKIKKADLHTILAHAHLRI----DQLSQKLIDSKLNEEKRIQSIIAKKK 352

  Fly   430 SEAL-RAQLEYHL-------EAERRKLAVENQKKIFHIHAESDKLLRLQLKKQAEAH-ADHIKDI 485
            .:.| :.:||.:.       |.:::||..|..:....|..:.|:.|:..::.|.:.: .:|.||:
Worm   353 EDLLEKLRLETNAKQAAVIPEFDKKKLDAELARATAEIQKKYDEKLKEVVRTQKQLYDIEHAKDV 417

  Fly   486 VAQRETDLTRSFKRELEDKLATEKANYKLQLAG-MLGKLRGMDAALA-EIEDEFQERADAERTAN 548
                             |:...::.|......| .|.:|.|::.||: .::.:.:.|
Worm   418 -----------------DEAVLKERNLHSSAVGKALAQLAGIEKALSGHLQMDIENR-------- 457

  Fly   549 QAQALWAACQALWASV----RAATPGVHYKDRLRPLKNEINAIAKVAKG---DDLVAAVLESVPK 606
            :::.:|.|.|.|..:|    ||:   ...:.|..||.:::..:.....|   |:.|..:..::.|
Worm   458 KSKQMWLATQNLKGTVIFGNRAS---CCMEGRRAPLGDQMKTLLSCCGGGNSDEFVKTINTAMSK 519

  Fly   607 EAQERGVYPEDALRERFLNVERVARRLALVPEEGAGLPIYFLSYLQSLFIL-----RPDNPISKD 666
            .::.||.|.|..|..||..|.|:.||:|.|.|.||...:|  |:|:|...:     :..|.....
Worm   520 TSKVRGEYTEQDLNTRFNKVCRIGRRVAYVNEGGALAHLY--SWLKSSLTIELVPKKGANESLTP 582

  Fly   667 ELENKPFDYSKLDTYDILNRARYHVDRSDFLQALKYMNLLQGASRKIAGEWMKEARLMLETQQAA 731
            .:||         .:.:|.||...........|::.:.|..||:|::|.:::.:||...|....:
Worm   583 AVEN---------NFTLLTRAEQLWKSGKKSDAIRVLQLTDGATRRVAADFIADARRQHEALLLS 638

  Fly   732 NTLMAHAAASGL 743
            ..|:||||.:.:
Worm   639 RLLLAHAALTSI 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitofilin	NP_001262819.1	Mitofilin	68..739	CDD:286774	155/721 (21%)
immt-2	NP_507241.2	Mitofilin	44..633	CDD:286774	148/700 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161692
Domainoid	1	1.000	207	1.000	Domainoid score	I1681
eggNOG	1	0.900	-	-		E1_KOG1854
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38234
Inparanoid	1	1.050	210	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48742
OrthoDB	1	1.010	-	-		D1073064at2759
OrthoFinder	1	1.000	-	-		FOG0005100
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103871
Panther	1	1.100	-	-	O	PTHR15415
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4724
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770