Protein Alignment Mitofilin and IMMT

DIOPT Version :9

• Sequence 1: NP_001262819.1
• Gene: Mitofilin / 42587
• FlyBaseID: FBgn0019960
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_006830.2
• Gene: IMMT / 10989
• HGNCID: 6047
• Length: 758
• Species: Homo sapiens
• Alignment Length: 840
• Identity: 229/840 - (27%)
• Similarity: 368/840 - (43%)
• Gaps: 202/840 - (24%)

  Fly     5 AVRDQCKCA--LQRTLQQTTANNRQFGGSSSGSGGREQGRRQQEEQGQQGDQGYQGYQSLPPHMR 67
            |....|.|.  :.|.|:..    |::  |:|||.|...|                         :
Human    12 AAAQSCLCGKFVLRPLRPC----RRY--STSGSSGLTTG-------------------------K 45

  Fly    68 EAGFGKVVLFVSPLAAVGGVITYAKYDDDFRKLVEKNVPGAGSVIKVALQEEPPFKGITKNVNDQ 132
            .||.|  :|||.  ..:||.|.|||:|..||:.|||.:|.:..:.::.|..      ...||...
Human    46 IAGAG--LLFVG--GGIGGTILYAKWDSHFRESVEKTIPYSDKLFEMVLGP------AAYNVPLP 100

  Fly   133 IDKVKSGIETVTSTVDSVTSKVTGLFGGGSGDDKSKKSKVEPVKA-TPAEEKRPSKPSEVSKTEA 196
            ...::||...::|..:.:.            :.|...|:::..|. |||....|::.:::.....
Human   101 KKSIQSGPLKISSVSEVMK------------ESKQPASQLQKQKGDTPASATAPTEAAQIISAAG 153

  Fly   197 KPVSKPAAAAAPAPAAKPKDNP-----------------------LPRDVV-------------- 224
            ..:|.||.|..|..:.| .|:|                       .|.:|.
Human   154 DTLSVPAPAVQPEESLK-TDHPEIGEGKPTPALSEEASSSSIRERPPEEVAARLAQQEKQEQVKI 217

  Fly   225 -----ELEKAIELSAQL---AVKEYNVAIGVLKGFNDDVRKVVDKAVENGE--NSLWTT----LK 275
                 .||.|:..:|.:   |:...|.|:..:...::.::..:|.:...||  ::.|.|    ||
Human   218 ESLAKSLEDALRQTASVTLQAIAAQNAAVQAVNAHSNILKAAMDNSEIAGEKKSAQWRTVEGALK 282

  Fly   276 NRASARDTAVATAERAAREAQEKIVACEIALSAAATAQNAKKVE---------AVRDKIKKLVDH 331
            .|..|.|.| |.|...|:|..||:         .:..:||||.|         |...|:..::..
Human   283 ERRKAVDEA-ADALLKAKEELEKM---------KSVIENAKKKEVAGAKPHITAAEGKLHNMIVD 337

  Fly   332 IGNVKDELYRHKDTASVSDKYWRNVEKARNYFIDEIESIFP-------GLSLADKKLNLSKEDLD 389
            :.||..::...:..|.|..:|...|.:||:.|..|::||.|       |:|::|....||.:||:
Human   338 LDNVVKKVQAAQSEAKVVSQYHELVVQARDDFKRELDSITPEVLPGWKGMSVSDLADKLSTDDLN 402

  Fly   390 LFILHAYTHV------LAYQK-----------ELQRLQTDGELRLKRAIDSVRGDNDSEALRAQL 437
            ..|.||:..:      ||.||           |.|:|:.      |||.||        |:...|
Human   403 SLIAHAHRRIDQLNRELAEQKATEKQHITLALEKQKLEE------KRAFDS--------AVAKAL 453

  Fly   438 EYHLEAERRKLAVENQKKIFHIHAESDKLLRLQLKKQAEAHADHIKDIVAQRETDLTRSFKRELE 502
            |:|    |.::..|..:||..:....:..:|.||::||.||.||::|::..:|.:|...|::.|.
Human   454 EHH----RSEIQAEQDRKIEEVRDAMENEMRTQLRRQAAAHTDHLRDVLRVQEQELKSEFEQNLS 514

  Fly   503 DKLATEKA-----------NYKLQLAGMLGKLRGMDAALAEIEDEFQERADAERTANQAQALWAA 556
            :||:.::.           |:.|.:.....:|||       ||...|..|.||..|.:|..||.:
Human   515 EKLSEQELQFRRLSQEQVDNFTLDINTAYARLRG-------IEQAVQSHAVAEEEARKAHQLWLS 572

  Fly   557 CQALWASVR---AATPGVHYKDRLRPLKNEINAIAKVAKGDDLVAAVLESVPKEAQERGVYPEDA 618
            .:||..|::   |.||.:       ||.:.:.||......::...|:..::|.|:..||||.|:.
Human   573 VEALKYSMKTSSAETPTI-------PLGSAVEAIKANCSDNEFTQALTAAIPPESLTRGVYSEET 630

  Fly   619 LRERFLNVERVARRLALVPEEGAGLPIYFLSYLQSLFILRPDNPISKDELENKPFDYSKLDTYDI 683
            ||.||..|:::|||:|::.|....|..|||||||||.:..|..  .|...|..|.|   ::|:.:
Human   631 LRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPQQ--LKPPPELCPED---INTFKL 690

  Fly   684 LNRARYHVDRSDFLQALKYMNLLQGASRKIAGEWMKEARLMLETQQAANTLMAHAAASGL 743
            |:.|.|.::..|...|.|::|.|:|.||::|.:|:||||:.|||:|....|.|:|:|.|:
Human   691 LSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASAVGI 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitofilin	NP_001262819.1	Mitofilin	68..739	CDD:286774	214/769 (28%)
IMMT	NP_006830.2	Mitofilin	44..746	CDD:313027	215/796 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..143		6/38 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..200		5/38 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150778
Domainoid	1	1.000	239	1.000	Domainoid score	I2288
eggNOG	1	0.900	-	-		E1_KOG1854
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38234
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3319
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48742
OrthoDB	1	1.010	-	-		D1073064at2759
OrthoFinder	1	1.000	-	-		FOG0005100
OrthoInspector	1	1.000	-	-		oto88609
orthoMCL	1	0.900	-	-		OOG6_103871
Panther	1	1.100	-	-	LDO	PTHR15415
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4607
SonicParanoid	1	1.000	-	-		X4724
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800