DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Idh3b and Idh3b

DIOPT Version :9

Sequence 1:	NP_001163682.1	Gene:	Idh3b / 42586	FlyBaseID:	FBgn0038922	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_446033.1	Gene:	Idh3b / 94173	RGDID:	621881	Length:	385	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	217/360 - (60%)
Similarity:	276/360 - (76%)	Gaps:	10/360 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AAAARSLHTTSTLRATDNYGANRT------TCTLIPGDGVGPELVYSLQEVFKAASVPVDFECYF 73
            :.|.|.|.|.::.:|.....|...      ..|::|||||||||:::::||||||:|||:|:.:.
  Rat    20 SGAWRGLRTAASAQAASQSQAQDVRVEGAFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFKEHH 84

  Fly    74 LSEI-NPVLSAKLEDVVASIQKNKVCIKGVLATP-DYSNVGDLQTLNMKLRNDLDLYANVVHVRS 136
            |||: |.....|||.|::|:::|||.|.|.:.|| :|.  |:|.:.:|:||..|||:||||||:|
  Rat    85 LSEVQNMASEEKLEQVLSSMKENKVAIIGKIYTPMEYK--GELASYDMQLRRKLDLFANVVHVKS 147

  Fly   137 LPGVKTRHTNIDTVIIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYATKNQRKK 201
            |||.||||.|:|.||||||||||||:|||||..|::|||||:|..||.||||||||||||..|.|
  Rat   148 LPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAFDYATKKGRSK 212

  Fly   202 VTAVHKANIMKLGDGLFLRSCEEVSRLYPRIQFEKMIVDNTTMQMVSNPNQFDVMVTPNLYGAIV 266
            ||||||||||||||||||:.||||:.|||:|:||.||:||..||:|.||.||||:|.|||||.|:
  Rat   213 VTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNII 277

  Fly   267 DNLASGLVGGAGVVAGASYSSESVVFEPGARHTFAEAVGKNVANPTAMLLCGVKLLRHINLPTYG 331
            ||||:|||||||||.|.|||:|..|||.||||.||:|||:|:||||||||....:|||:||..:.
  Rat   278 DNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHS 342

  Fly   332 EIIQNAINKVLNDGKVRTKDLGGQSTTQDFTRAII 366
            .:|.:|:.||:..|||||:|:||.|||.||.:::|
  Rat   343 SMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVI 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3b	NP_001163682.1	Iso_dh	37..369	CDD:294303	211/338 (62%)
Idh3b	NP_446033.1	Iso_dh	47..380	CDD:294303	210/327 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353515
Domainoid	1	1.000	421	1.000	Domainoid score	I616
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5035
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1705
OMA	1	1.010	-	-		QHG53770
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	1	1.000	-	-		oto96753
orthoMCL	1	0.900	-	-		OOG6_101342
Panther	1	1.100	-	-	LDO	PTHR11835
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1965
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770