DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3b and IDH1

DIOPT Version :9

Sequence 1:	NP_001163682.1	Gene:	Idh3b / 42586	FlyBaseID:	FBgn0038922	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_014361.1	Gene:	IDH1 / 855691	SGDID:	S000004982	Length:	360	Species:	Saccharomyces cerevisiae

Alignment Length:	372	Identity:	176/372 - (47%)
Similarity:	246/372 - (66%)	Gaps:	18/372 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MLARTVGRTFMQAAAARSLHTTSTLRAT--DNYGANRTTCTLIPGDGVGPELVYSLQEVFKAASV 65
            ||.||:        |.|:|.|.:....|  ..|| .|.|.|||||||||.|:..|::.:|:|.::
Yeast     1 MLNRTI--------AKRTLATAAQAERTLPKKYG-GRFTVTLIPGDGVGKEITDSVRTIFEAENI 56

  Fly    66 PVDFECYFLSEINPVLSAKLEDVVASIQKNKVCIKGVLATP-DYSNVGDLQTLNMKLRNDLDLYA 129
            |:|:|...:.:.:.  ...:.:.|.|:::||:.:||:..|| |.:..|   :||:.||..||:||
Yeast    57 PIDWETINIKQTDH--KEGVYEAVESLKRNKIGLKGLWHTPADQTGHG---SLNVALRKQLDIYA 116

  Fly   130 NVVHVRSLPGVKTRHTNIDTVIIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYA 194
            ||...:||.|||||..:||.::|||.||||:|.||||||||:||.||::|..|:.|||:||||:|
Yeast   117 NVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFA 181

  Fly   195 TKNQRKKVTAVHKANIMKLGDGLFLRSCEEV-SRLYPRIQFEKMIVDNTTMQMVSNPNQFDVMVT 258
            .|..||.|||||||||||||||||.....|: .:.||.|....:||||.:||.|:.|:||||:||
Yeast   182 KKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVT 246

  Fly   259 PNLYGAIVDNLASGLVGGAGVVAGASYSSESVVFEPGARHTFAEAVGKNVANPTAMLLCGVKLLR 323
            |::||.|:.|:.:.|:||.|:||||::..:..|||||:||...:..|:||||||||:|....:|.
Yeast   247 PSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLN 311

  Fly   324 HINLPTYGEIIQNAINKVLNDGKVRTKDLGGQSTTQDFTRAIILNMS 370
            |:.|..|...|..|:::.:.:||..|:|:||.|:|.|||..||..:|
Yeast   312 HLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLS 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3b	NP_001163682.1	Iso_dh	37..369	CDD:294303	164/333 (49%)
IDH1	NP_014361.1	mito_nad_idh	26..357	CDD:272942	165/336 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346416
Domainoid	1	1.000	314	1.000	Domainoid score	I197
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5035
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S528
OMA	1	1.010	-	-		QHG53770
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101342
Panther	1	1.100	-	-	LDO	PTHR11835
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R585
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.690