DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3b and IDH2

DIOPT Version :9

Sequence 1:	NP_001163682.1	Gene:	Idh3b / 42586	FlyBaseID:	FBgn0038922	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_014779.1	Gene:	IDH2 / 854303	SGDID:	S000005662	Length:	369	Species:	Saccharomyces cerevisiae

Alignment Length:	372	Identity:	147/372 - (39%)
Similarity:	223/372 - (59%)	Gaps:	26/372 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TFMQAAAARSLHTT---STLRAT--DNYGANRTTCTLIPGDGVGPELVYSLQEVFKAASVPVDFE 70
            ||.:..:.|.|.|.   |..|.|  .|....:.|.:.|.|||:|||:..|::::|.||:||:::|
Yeast     5 TFFRNTSRRFLATVKQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWE 69

  Fly    71 -CYFLSEINPV----LSAKLEDVVASIQKNKVCIKGVLATPDYSNVG-DLQTLNMKLRNDLDLYA 129
             |    :::|:    |:...:..|.||.||.|.:||.||||    :| ..::||:.||....|:|
Yeast    70 SC----DVSPIFVNGLTTIPDPAVQSITKNLVALKGPLATP----IGKGHRSLNLTLRKTFGLFA 126

  Fly   130 NVVHVRSLPGVKTRHTNIDTVIIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYA 194
            ||...:|:.|.||.:.|:|.|:|||.||||||.:||...||:|:.:|:||...|.|:.::||:||
Yeast   127 NVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYA 191

  Fly   195 TKNQRKKVTAVHKANIMKLGDGLFLRSCEEVSRLYPRIQFEKMIVDNTTMQMVSNPNQFD--VMV 257
            ....|.:|..|||:.|.:|.||||:...:|:|:.||.:..|..::||:.:::|:||:.:.  |.|
Yeast   192 RAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSV 256

  Fly   258 TPNLYGAIVDNLASGL-VGGAGVVAGASYSSESVVFEPGARHTFA-EAVGKNVANPTAMLLCGVK 320
            .|||||.|:.:|.||| .|..|:...|:...:..:||  |.|..| :..|::.|||||:||..|.
Yeast   257 CPNLYGDILSDLNSGLSAGSLGLTPSANIGHKISIFE--AVHGSAPDIAGQDKANPTALLLSSVM 319

  Fly   321 LLRHINLPTYGEIIQNAINKVLNDG-KVRTKDLGGQSTTQDFTRAII 366
            :|.|:.|..:.:.||||:...:..| :.||.||.|.:||..||.|:|
Yeast   320 MLNHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVI 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3b	NP_001163682.1	Iso_dh	37..369	CDD:294303	138/341 (40%)
IDH2	NP_014779.1	LeuB	34..369	CDD:223549	138/343 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53770
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820