DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3b and idh3b

DIOPT Version :9

Sequence 1:	NP_001163682.1	Gene:	Idh3b / 42586	FlyBaseID:	FBgn0038922	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	XP_017208256.1	Gene:	idh3b / 415247	ZFINID:	ZDB-GENE-040625-174	Length:	386	Species:	Danio rerio

Alignment Length:	371	Identity:	222/371 - (59%)
Similarity:	282/371 - (76%)	Gaps:	7/371 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LARTVGRTFMQAAAARSLHTTSTLRATDNYGANRTT---CTLIPGDGVGPELVYSLQEVFKAASV 65
            ||:.:....:|...||||..||:....::..|...:   .|::|||||||||:.:::||||||.|
Zfish    13 LAKGLTGVRLQPLCARSLSLTSSQNVPESPPARADSTFKVTMVPGDGVGPELMTAVKEVFKAADV 77

  Fly    66 PVDFECYFLSEI-NPVLSAKLEDVVASIQKNKVCIKGVLATP-DYSNVGDLQTLNMKLRNDLDLY 128
            ||:||.:.|||: |.....||.:|::|::.|:|.|||.:.|| :|.  |:|.:..|:||..|||:
Zfish    78 PVEFEEFHLSEVQNMASEEKLNEVLSSMKNNRVAIKGKIHTPMEYK--GELASYEMRLRRKLDLF 140

  Fly   129 ANVVHVRSLPGVKTRHTNIDTVIIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDY 193
            ||||||:||||..|||.|:|.||||||||||||:||||||.|:||||||||.:||.|||||||||
Zfish   141 ANVVHVKSLPGYSTRHNNLDLVIIREQTEGEYSSLEHESVAGVVECLKIITREKSRRIAKFAFDY 205

  Fly   194 ATKNQRKKVTAVHKANIMKLGDGLFLRSCEEVSRLYPRIQFEKMIVDNTTMQMVSNPNQFDVMVT 258
            |||..|.|||||||||||||||||||:||.||:.|||:|::|.:|:||..||:|.||.||||:|.
Zfish   206 ATKKGRSKVTAVHKANIMKLGDGLFLQSCAEVAELYPKIKYENVIIDNCCMQLVQNPYQFDVLVM 270

  Fly   259 PNLYGAIVDNLASGLVGGAGVVAGASYSSESVVFEPGARHTFAEAVGKNVANPTAMLLCGVKLLR 323
            |||||.|:||||:|||||||||.|.|||:|..|||.||||.||:|||:|:||||||||....:|:
Zfish   271 PNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLK 335

  Fly   324 HINLPTYGEIIQNAINKVLNDGKVRTKDLGGQSTTQDFTRAIILNM 369
            |:||..:..::..|:.||:..|||||:||||.|||.||.|||:.::
Zfish   336 HLNLEYHSNMVSEAVKKVIKQGKVRTRDLGGYSTTGDFIRAIVASL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3b	NP_001163682.1	Iso_dh	37..369	CDD:294303	212/336 (63%)
idh3b	XP_017208256.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595645
Domainoid	1	1.000	423	1.000	Domainoid score	I603
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5035
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1683
OMA	1	1.010	-	-		QHG53770
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	1	1.000	-	-		oto39674
orthoMCL	1	0.900	-	-		OOG6_101342
Panther	1	1.100	-	-	LDO	PTHR11835
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R585
SonicParanoid	1	1.000	-	-		X1965
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800