DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3b and IDH3G

DIOPT Version :9

Sequence 1:	NP_001163682.1	Gene:	Idh3b / 42586	FlyBaseID:	FBgn0038922	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_004126.1	Gene:	IDH3G / 3421	HGNCID:	5386	Length:	393	Species:	Homo sapiens

Alignment Length:	364	Identity:	186/364 - (51%)
Similarity:	247/364 - (67%)	Gaps:	25/364 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ARSLHTTSTLRATDNYGANRTTCTLIPGDGVGPELVYSLQEVFKAASVPVDFECYFLSEINPVLS 82
            :|::.:..|:..:..|| .|.|.|:|||||:||||:..::.||:.|.||||||     |::...:
Human    36 SRNIFSEQTIPPSAKYG-GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFE-----EVHVSSN 94

  Fly    83 AKLEDV---VASIQKNKVCIKGVLAT-----PDYSNVGDLQTLNMKLRNDLDLYANVVHVRSLPG 139
            |..||:   :.:|::|:|.:||.:.|     |.:      ::.|..||..|||||||:|.:||||
Human    95 ADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSH------KSRNNILRTSLDLYANVIHCKSLPG 153

  Fly   140 VKTRHTNIDTVIIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYATKNQRKKVTA 204
            |.|||.:||.:|:||.||||||:||||||.|:||.|||||..||:|||::||..|.::.||||||
Human   154 VVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTA 218

  Fly   205 VHKANIMKLGDGLFLRSCEEVSRLYPRIQFEKMIVDNTTMQMVSNPNQFDVMVTPNLYGAIVDNL 269
            |||||||||||||||:.|.||:..||:|.||.|||||||||:||.|.||||||.|||||.||:|:
Human   219 VHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNV 283

  Fly   270 ASGLVGGAGVVAGASYSSESVVFEPGARHTFAEAVGKNVANPTAMLLCGVKLLRHINLPTYGEII 334
            .:|||||.|:||||:|.....|||...|:|......||:|||||.||....:|.|:.|.:|...|
Human   284 CAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSI 348

  Fly   335 QNAINKVLNDGKVRTKDLGGQSTT----QDFTRAI-ILN 368
            :.|:...:::..:.|.|:|||.||    ||..|.| ::|
Human   349 RKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIRVIN 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3b	NP_001163682.1	Iso_dh	37..369	CDD:294303	182/345 (53%)
IDH3G	NP_004126.1	mito_nad_idh	52..383	CDD:272942	181/342 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53770
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101342
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730