DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3b and IDH3B

DIOPT Version :9

Sequence 1:	NP_001163682.1	Gene:	Idh3b / 42586	FlyBaseID:	FBgn0038922	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001317692.1	Gene:	IDH3B / 3420	HGNCID:	5385	Length:	387	Species:	Homo sapiens

Alignment Length:	359	Identity:	218/359 - (60%)
Similarity:	275/359 - (76%)	Gaps:	7/359 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RTFMQAAAARSLHTTSTLRATDNYGANRTTCTLIPGDGVGPELVYSLQEVFKAASVPVDFECYFL 74
            |....:|||   |..|..:|.|.........|::|||||||||:::::||||||:|||:|:.:.|
Human    24 RGLSTSAAA---HAASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHL 85

  Fly    75 SEI-NPVLSAKLEDVVASIQKNKVCIKGVLATP-DYSNVGDLQTLNMKLRNDLDLYANVVHVRSL 137
            ||: |.....|||.|::|:::|||.|.|.:.|| :|.  |:|.:.:|:||..|||:||||||:||
Human    86 SEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYK--GELASYDMRLRRKLDLFANVVHVKSL 148

  Fly   138 PGVKTRHTNIDTVIIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYATKNQRKKV 202
            ||..|||.|:|.||||||||||||:|||||..|::|||||:|..||.||||||||||||..|.||
Human   149 PGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKV 213

  Fly   203 TAVHKANIMKLGDGLFLRSCEEVSRLYPRIQFEKMIVDNTTMQMVSNPNQFDVMVTPNLYGAIVD 267
            |||||||||||||||||:.||||:.|||:|:||.||:||..||:|.||.||||:|.|||||.|:|
Human   214 TAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIID 278

  Fly   268 NLASGLVGGAGVVAGASYSSESVVFEPGARHTFAEAVGKNVANPTAMLLCGVKLLRHINLPTYGE 332
            |||:|||||||||.|.|||:|..|||.||||.||:|||:|:||||||||....:|||:||..:..
Human   279 NLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSS 343

  Fly   333 IIQNAINKVLNDGKVRTKDLGGQSTTQDFTRAII 366
            :|.:|:.||:..|||||:|:||.|||.||.:::|
Human   344 MIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVI 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3b	NP_001163682.1	Iso_dh	37..369	CDD:294303	210/332 (63%)
IDH3B	NP_001317692.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159470
Domainoid	1	1.000	420	1.000	Domainoid score	I639
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5035
Inparanoid	1	1.050	424	1.000	Inparanoid score	I1774
Isobase	1	0.950	-	0	Normalized mean entropy	S528
OMA	1	1.010	-	-		QHG53770
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	1	1.000	-	-		oto89642
orthoMCL	1	0.900	-	-		OOG6_101342
Panther	1	1.100	-	-	LDO	PTHR11835
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R585
SonicParanoid	1	1.000	-	-		X1965
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750