DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3b and IDH3A

DIOPT Version :9

Sequence 1:	NP_001163682.1	Gene:	Idh3b / 42586	FlyBaseID:	FBgn0038922	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_005521.1	Gene:	IDH3A / 3419	HGNCID:	5384	Length:	366	Species:	Homo sapiens

Alignment Length:	343	Identity:	144/343 - (41%)
Similarity:	207/343 - (60%)	Gaps:	11/343 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RATDNYGANRTTCTLIPGDGVGPELVYSLQEVFKAASVPVDFECYFLSEINP-----VLSAKLED 87
            :.|..:.....|.|||||||:|||:..::.::|.||..|:.:|...::.|..     ::.::.::
Human    22 QVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKE 86

  Fly    88 VVASIQKNKVCIKGVLATPDYSNVGDLQTLNMKLRNDLDLYANVVHVRSLPGVKTRHTNIDTVII 152
               |:.|||:.:||.|.||   ......::|:.||...||||||....|:.|.||.:|:::.|.|
Human    87 ---SMDKNKMGLKGPLKTP---IAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTI 145

  Fly   153 REQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYATKNQRKKVTAVHKANIMKLGDGL 217
            ||.||||||.:||..|.|:|:.:|:||...|.|||:|||:||..|.|..||||||||||::.|||
Human   146 RENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGL 210

  Fly   218 FLRSCEEVSRLYPRIQFEKMIVDNTTMQMVSNPNQFDVMVTPNLYGAIVDNLASGLVGGAGVVAG 282
            ||:.|.||:.....|:|.:|.:|...:.||.:|:||||:|.|||||.|:.:|.:||:||.||...
Human   211 FLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPS 275

  Fly   283 ASYSSESVVFEPGARHTFAEAVGKNVANPTAMLLCGVKLLRHINLPTYGEIIQNAINKVLNDGKV 347
            .:..:..|........|..:..||::|||||:||..|.:|||:.|..:...|:.|....:.|||.
Human   276 GNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKDGKS 340

  Fly   348 RTKDLGGQSTTQDFTRAI 365
            .||||||.:...|||..|
Human   341 LTKDLGGNAKCSDFTEEI 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3b	NP_001163682.1	Iso_dh	37..369	CDD:294303	143/334 (43%)
IDH3A	NP_005521.1	mito_nad_idh	29..362	CDD:272942	143/336 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53770
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830