DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3b and Idh3b

DIOPT Version :9

Sequence 1:	NP_001163682.1	Gene:	Idh3b / 42586	FlyBaseID:	FBgn0038922	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_570954.1	Gene:	Idh3b / 170718	MGIID:	2158650	Length:	384	Species:	Mus musculus

Alignment Length:	366	Identity:	218/366 - (59%)
Similarity:	277/366 - (75%)	Gaps:	6/366 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MLARTVGRTFMQAAAARSLHTTSTLRATDNYGANRTTCTLIPGDGVGPELVYSLQEVFKAASVPV 67
            :.||..|.  .:.....:.|..|..:|.|.........|::|||||||||:::::||||||:|||
Mouse    15 LAARNSGA--WRGLGTSTAHAASQSQAQDVRVEGAFPVTMLPGDGVGPELMHAVKEVFKAAAVPV 77

  Fly    68 DFECYFLSEI-NPVLSAKLEDVVASIQKNKVCIKGVLATP-DYSNVGDLQTLNMKLRNDLDLYAN 130
            :|:.:.|||: |.....|||.|::|:::|||.|.|.:.|| :|.  |:|.:.:|:||..|||:||
Mouse    78 EFKEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIYTPMEYK--GELASYDMQLRRKLDLFAN 140

  Fly   131 VVHVRSLPGVKTRHTNIDTVIIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYAT 195
            ||||:||||.||||.|:|.||||||||||||:|||||..|::|||||:|..||.|||||||||||
Mouse   141 VVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESAKGVIECLKIVTRTKSQRIAKFAFDYAT 205

  Fly   196 KNQRKKVTAVHKANIMKLGDGLFLRSCEEVSRLYPRIQFEKMIVDNTTMQMVSNPNQFDVMVTPN 260
            |..|.|||||||||||||||||||:.||||:.|||:|:||.||:||..||:|.||.||||:|.||
Mouse   206 KKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPN 270

  Fly   261 LYGAIVDNLASGLVGGAGVVAGASYSSESVVFEPGARHTFAEAVGKNVANPTAMLLCGVKLLRHI 325
            |||.|:||||:|||||||||.|.|||:|..|||.||||.||:|||:|:||||||||....:|||:
Mouse   271 LYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSATNMLRHL 335

  Fly   326 NLPTYGEIIQNAINKVLNDGKVRTKDLGGQSTTQDFTRAII 366
            ||..:..:|.:|:.||:..|||||:|:||.|||.||.:::|
Mouse   336 NLEYHSSMIADAVKKVIKAGKVRTRDMGGYSTTTDFIKSVI 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3b	NP_001163682.1	Iso_dh	37..369	CDD:294303	211/332 (64%)
Idh3b	NP_570954.1	Iso_dh	46..379	CDD:351095	211/335 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849839
Domainoid	1	1.000	423	1.000	Domainoid score	I619
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5035
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1731
Isobase	1	0.950	-	0	Normalized mean entropy	S528
OMA	1	1.010	-	-		QHG53770
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	1	1.000	-	-		oto93211
orthoMCL	1	0.900	-	-		OOG6_101342
Panther	1	1.100	-	-	LDO	PTHR11835
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R585
SonicParanoid	1	1.000	-	-		X1965
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740