DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox2 and Qsox2

DIOPT Version :9

Sequence 1:	NP_650998.1	Gene:	Qsox2 / 42583	FlyBaseID:	FBgn0038919	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001102904.1	Gene:	Qsox2 / 681023	RGDID:	1584720	Length:	708	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	169/556 - (30%)
Similarity:	273/556 - (49%)	Gaps:	51/556 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLISPADVLGRLNARKSANEASLYS-DTDNVIMLDIESLRPAL-NLKNSKLVQFLNSFCGDCHR 74
            |||::....:|    .:....|.||. ..|.|.:||..|:|.|. |...:.||||.:|:||.|..
  Rat    46 LLLLAVVAAVG----PQEGGGARLYRVGEDAVWLLDSGSVRSATGNSSAAWLVQFHSSWCGHCIG 106

  Fly    75 FAPVFKTLSRDLYKWRRILRIYAVDCAQERNAQLCREFNIRQTPSLRFFGPDMRKNDDVLGAVIP 139
            :||.::.|:.|:..|...:|:.|:|||:|:|..:||.::|...|:.|:|....:  :...|....
  Rat   107 YAPTWRALAADVRDWAAAIRVAALDCAEEKNQDVCRTYDIHFYPTFRYFRAFTK--EFTTGENFK 169

  Fly   140 GQDPEF--ISSTLAELVSQNDYG---PGQPNFRPLKATDYEIFQDQDGETPIQFVALVLQPKNSK 199
            |.|.|.  :..|:.:.:..:..|   |..|...|::::|...|.|....   |:.|:|.:...|.
  Rat   170 GPDRELRTVRQTMIDFLQNHTEGSRPPACPPLDPIQSSDILSFMDSHSG---QYHAVVFESNGSY 231

  Fly   200 IGRDTLLELLPFKELSV-RIIE-DSQIFNEFGLG--PDDQKLAIVDRNGTAQYLTPSSDSSEAYA 260
            :||:.:|:|:|:..:.| |.:: |.......|:.  |....:.....:|......|......:|.
  Rat   232 VGREVILDLIPYDNIMVSRALDTDKAFLGTLGISSVPSCYLIYPNGSHGLVNVAKPLRSFFSSYL 296

  Fly   261 STIGDFLKNRNIQPDPPLPIAVAPNFTEFLDHQNQAILTKVLTPPLQVYRADLEQAIDKLLHIEL 325
            .::.|..|.....|:.|..           :..::.::.|.. ...::|.||||..:..||.:||
  Rat   297 KSLPDVRKKSLSLPEKPNK-----------EENSEVVIWKEF-DRAKLYTADLESGLHYLLRVEL 349

  Fly   326 RKWVLLEGNSLNALKNIIKIFRYLNPLNKDGKLLLTDLDNSLSSKQSIKGADFGDLVDSLENGRR 390
            .....|.|..|...|:.:.:...|.|.....|.||..|...|::....| ..:..::|.:.|..:
  Rat   350 AAHRSLAGAQLKTFKDFVTVIAKLFPGRPPVKKLLETLHEWLANLPLDK-IPYNAILDLVNNKMQ 413

  Fly   391 V---FKARR--YVGCIGSRPLLRSFTCSMWTLFHHLTVEAAKPPNY-----FEAG--SILKTFHG 443
            :   |....  :|||.|||..||.:.||:|.|||.|||:|:..|..     ||..  ::|:|...
  Rat   414 ISGLFLTSHITWVGCQGSRLELRGYPCSLWKLFHTLTVQASTHPEALVGTGFEGDPQAVLQTMRR 478

  Fly   444 FAKYFFGCTDCSEHFQQMAIRRNLTSVKTHDEEILWLWAAHNEVNARIAGDSTEDPKFPKIQFPS 508
            :.:.||||.:|.|||::|| :.::.||||.|:.:||||..||.||:|:||..:|||||||:.:|:
  Rat   479 YIRTFFGCKECGEHFEEMA-KESMDSVKTADQAVLWLWRKHNMVNSRLAGHLSEDPKFPKVPWPT 542

  Fly   509 AENCPTCRSN----DSEWRTDEVLKYLKQLYDINNV 540
            .:.||.|...    || |..::||.:|||.|..:|:
  Rat   543 PDLCPVCHEEIKGLDS-WDEEQVLVFLKQHYSRDNL 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox2	NP_650998.1	PDI_a_QSOX	40..152	CDD:239290	39/114 (34%)
Qsox2	NP_650998.1	Evr1_Alr	413..504	CDD:282612	46/97 (47%)
Qsox2	NP_001102904.1	PDI_a_QSOX	71..184	CDD:239290	38/116 (33%)
Qsox2	NP_001102904.1	Evr1_Alr	441..538	CDD:282612	49/103 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339514
Domainoid	1	1.000	113	1.000	Domainoid score	I5973
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H65608
Inparanoid	1	1.050	270	1.000	Inparanoid score	I2928
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8977
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770