DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox2 and QSOX1

DIOPT Version :9

Sequence 1:	NP_650998.1	Gene:	Qsox2 / 42583	FlyBaseID:	FBgn0038919	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_002817.2	Gene:	QSOX1 / 5768	HGNCID:	9756	Length:	747	Species:	Homo sapiens

Alignment Length:	572	Identity:	176/572 - (30%)
Similarity:	286/572 - (50%)	Gaps:	81/572 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKTLLYCLLLISPADVLGRLNARKSANEASLYSDTDNVIMLDIESLRPA-LNLKNSKLVQFLNSF 68
            |..||..||.:..|:         :|..::|||.:|.:.:|..:::|.| |..:::..|:|..|:
Human    14 LLLLLLWLLAVPGAN---------AAPRSALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASW 69

  Fly    69 CGDCHRFAPVFKTLSRDLYKWRRILRIYAVDCAQERNAQLCREFNIRQTPSLRFFGPDMRKNDDV 133
            ||.|..|||.:|.|:.|:..||..|.:.|:|||:|.|:.:||:|||...|::||| ....||..
Human    70 CGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRFF-KAFTKNGS- 132

  Fly   134 LGAVIP--GQDPEFISSTLAE-LVSQND-YGPGQPNFRPLKATDYEIFQDQDGETPIQFVALVLQ 194
             |||.|  |.|.:.:...|.: |.|.:| :.|..|...|.|..:.:.|..::.|   :::||:.:
Human   133 -GAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNNE---EYLALIFE 193

  Fly   195 PKNSKIGRDTLLELLPFKELSVRII--EDSQIFNEFGLGPDDQKLAIVDRNG------------- 244
            ...|.:||:..|:|...|.::||.:  .::.:..:||: .|.....::.|||
Human   194 KGGSYLGREVALDLSQHKGVAVRRVLNTEANVVRKFGV-TDFPSCYLLFRNGSVSRVPVLMESRS 257

  Fly   245 --TAQYLTPSSDSSEAYASTIGDFLKNRNIQPDPPLPIAVAPNFTEFLDHQNQAILTKVLTPPLQ 307
              ||.....|..:.||..:|:.....|:           :||...:..|..             :
Human   258 FYTAYLQRLSGLTREAAQTTVAPTTANK-----------IAPTVWKLADRS-------------K 298

  Fly   308 VYRADLEQAIDKLLHIELRKWVLLEGNSLNALKNIIKIFRYLNPLNKDGKLLLTDLDNSLS---- 368
            :|.||||.|:..:|.||:.::.:|||..|.|||..:.:.....|    |:.|:.:..:|::
Human   299 IYMADLESALHYILRIEVGRFPVLEGQRLVALKKFVAVLAKYFP----GRPLVQNFLHSVNEWLK 359

  Fly   369 --SKQSIKGADFGDLVDSLENGRRVFKARRYVGCIGSRPLLRSFTCSMWTLFHHLTVEAAK---- 427
              .:..|..:.|...:|..:.|..:.|...::||.||.|..|.|.||:|.|||.|||:||:
Human   360 RQKRNKIPYSFFKTALDDRKEGAVLAKKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAARQNVD 424

  Fly   428 -PPNYFEAGSILKTFHGFAKYFFGCTDCSEHFQQMAIRRNLTSVKTHDEEILWLWAAHNEVNARI 491
             .....:|..:|....|:..|||||.||:.||:||| ..::..|.:.:..:||||::||.||||:
Human   425 HSQEAAKAKEVLPAIRGYVHYFFGCRDCASHFEQMA-AASMHRVGSPNAAVLWLWSSHNRVNARL 488

  Fly   492 AGDSTEDPKFPKIQFPSAENCPTCRSNDSE---WRTDEVLKYLKQLYDINNV 540
            ||..:|||:|||:|:|..|.|..|.:...:   |..:..|.:||..:..:|:
Human   489 AGAPSEDPQFPKVQWPPRELCSACHNERLDVPVWDVEATLNFLKAHFSPSNI 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox2	NP_650998.1	PDI_a_QSOX	40..152	CDD:239290	44/114 (39%)
Qsox2	NP_650998.1	Evr1_Alr	413..504	CDD:282612	43/95 (45%)
QSOX1	NP_002817.2	PDI_a_QSOX	40..152	CDD:239290	44/114 (39%)
		Evr1_Alr	406..501	CDD:282612	43/95 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145809
Domainoid	1	1.000	45	1.000	Domainoid score	I12204
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3076
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8504
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3816
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800